Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia (ASC2ESCALATE)

Investigator: Shilpan Shah, MD

Study Coordinator: Danielle Sewall

Status: Enrolling

ClinicalTrials.gov Number: NCT05384587

Phone: 346.238.2674

Protocol Number: PRO00037739

Description

This will be a multicenter Phase II open-label study of asciminib in CML-CP patients who have been previously treated with one prior ATP- binding site TKI with discontinuation due to treatment failure, warning or intolerance. (2L patient cohort). In addition, newly diagnosed CML-CP patients who may have received up to 4 weeks of prior TKI are included in a separate 1L patient cohort.
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