Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Nilene Crisci
Phone: 713.441.3771
To clarify the role of inflammation in the pathogenesis of AD, it is important to measure inflammation in brain of people with AD and its relationship with abnormal tau, as the disease progresses. So far, there is no in vivo data in humans verif ... Read more >
Status: Enrolling
Investigator: Gustavo Roman
Study Coordinator: Edwin Vega Vargas
Phone: 713.443.2044
This is a Phase IIa, randomized, double-blinded, placebo-controlled trial to determine the tolerability of L-serine for Mild Cognitive Impairment patients and assess preliminary indications of efficacy. Efficacy will be assessed by cognitive tes ... Read more >
Status: Enrolling
Investigator: Stanley Appel
Study Coordinator: Anjana Singh
Phone: 713.441.9120
The purpose of this protocol is to develop and maintain a biospecimen bank comprised of blood, urine, CSF collected during diagnostic evaluations, tissue from biopsies and autopsies collected from patients with neurological disease and non-neu ... Read more >
Status: Enrolling
Investigator: Juan Toledo Atucha
Study Coordinator: Maushami Gurung
Phone: 346.238.1565
The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease. Additional participants will be enrolled to an addendum safety cohort. The participants will be administere ... Read more >
Status: Enrolling
Investigator: Juan Toledo Atucha
Study Coordinator: Benjamin Batista Ramos
Phone: 346.238.1259
The primary purpose of this study is to determine whether treatment with lecanemab is superior to placebo on change from baseline of the Preclinical Alzheimer Cognitive Composite 5 (PACC5) at 216 weeks of treatment (A45 Trial) and to determine w ... Read more >
Status: Open Not Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Benjamin Batista Ramos
Phone: 346.238.1259
The overall goal of ADNI3 is to determine the relationships among the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD), as the pathology evolves from normal aging ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Chimaoge Onyechi
Phone: 713.363.7729
Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigat ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Chimaoge Onyechi
Phone: 713.363.7729
Elderly humans have an increased risk of dementia which begins as mild defects in memory called mild cognitive impairment. Glutathione (GSH), a key endogenous antioxidant has been linked to cognition. This exploratory study will investigate mech ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Andrea Franco Pando
Phone: 713.441.1150
The purpose of this study is to clarify at the individual level what genes and changes in the body predispose people to Alzheimer’s disease or other dementias. We will measure changes in brain imaging, body fluids, and memory or thinking abiliti ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Jeffrey Ling
Phone: 713.363.7753
The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator:
Phone:
The purpose of the study is to see if daily transdermal nicotine is able to produce a significant cognitive, clinical and functional improvement in participants with MCI. Neuronal nicotinic receptors have long been known to play a critical role ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Chimaoge Onyechi
Phone: 713.363.7729
New IDEAS is an observational, open-label, longitudinal cohort study designed to address the requirements of the CED provisions of the NCD on beta-amyloid PET. Building on the initial Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study, ... Read more >
Status: Enrolling
Investigator: Joseph Masdeu
Study Coordinator: Nilene Crisci
Phone: 713.441.3771
The discovery of AD risk genes coding for proteins involved in inflammation has revived the interest in neuroinflammation (or brain inflammation) in the pathogenesis of AD. To understand the role of inflammation in the pathogenesis of AD, it is ... Read more >