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Status: Open Not Enrolling
Investigator: Dipan Shah
Study Coordinator: Bevin Lopez
Phone: 346.238.5810
This study is designed to evaluate the efficacy of Dotarem enhanced MRI compared to Magnevist and Gadavist enhanced MRI in identifying myocardial infarct. Eighty patients will be recruited for this study. Patients with known CAD and undergoing c ... Read more >
Status: Enrolling
Investigator: Mahwash Kassi
Study Coordinator:
Phone:
NCT06183931 The primary objective of this study is to access the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the total occurrences ... Read more >
Status: Open Not Enrolling
Investigator: Kershaw Patel
Study Coordinator: Iris Alanis
Phone: 713.441.6548
A Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat (an aldosterone synthase inhibitor), administered on a background of a standardized anti-hypertensive (AHT) medication regimen, in subjects with uncontrolled and/or t ... Read more >
Status: Enrolling
Investigator: Maham Rahimi
Study Coordinator: Solange Basagoitia
Phone: 713.441.0176
This study aims to determine the safety and effectiveness of IMPEDE-FX RapidFill to increase the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label endovascular aneurysm repair (EVAR) s ... Read more >
Status: Open Not Enrolling
Investigator: Sherif Nagueh
Study Coordinator: Nirali Patel
Phone: 713.441.2116
Multicenter, Randomized, Double-blind, Parallel-group Extension to Study AC-058B201 to Investigate the Long-term Safety, Tolerability, and Efficacy of Three Doses of ACT-128800, an Oral S1P1 Receptor Agonist, in Patients With Relapsing-remitting ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: Deena Victor
Phone: 713.441.4536
Brief Summary: To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR. Detailed Descripti ... Read more >
Status: Enrolling
Investigator: Miguel Valderrabano
Study Coordinator: Aneesch Martin
Phone: 713.441.6548
Brief Summary: The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-t ... Read more >
Status: Enrolling
Investigator: Marvin Atkins
Study Coordinator: Padmaja Naik
Phone: 713.441.7386
The purpose of this study is to characterize the safety and effectiveness of the Medtronic Avalus Ultra aortic valve bioprosthesis in patients with aortic valve disease. ... Read more >
Status: Open Not Enrolling
Investigator: Mahwash Kassi
Study Coordinator: Jan-Michael Ragunton
Phone: 346.238.0218
To evaluate the efficacy of eplontersen compared to placebo for 120 weeks in patients with ATTR-CM receiving available standard of care (SoC). For more information, please visit https://www.cardio-ttransform.com. ... Read more >
Status: Enrolling
Investigator: Sachin Goel
Study Coordinator: Deena Victor
Phone: 713.441.4536
Brief Summary: The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral regurgitation = Grade III in whom transcatheter therapy i ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: Deena Victor
Phone: 713.441.4536
The primary objective of the study is to evaluate the safety and effectiveness of the Medtronic CoreValve® System (MCS) in a subset of subjects excluded from the U.S. Extreme Risk Pivotal Trial population due to one or more additional co-morbidi ... Read more >
Status: Enrolling
Investigator: David Chiu
Study Coordinator:
Phone:
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asym ... Read more >
Status: Open Not Enrolling
Investigator: Miguel Valderrabano
Study Coordinator: Chinwe Ngumezi
Phone: 713.441.6548
Brief Summary: The purpose of the Diamond-AF II study is to establish the safety and effectiveness of the DiamondTemp Ablation System for the treatment of drug refractory, symptomatic persistent atrial fibrillation in patients. Detailed Desc ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Deena Victor
Phone: 713.441.4536
Brief Summary: To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair System in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surger ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Padmaja Naik
Phone: 713.441.7386
To demonstrate the safety and effectiveness of the Reducer system for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myoc ... Read more >
Status: Enrolling
Investigator: Sachin Goel
Study Coordinator: Tia McGaughy
Phone: 346.238.4576
The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treating patients with symptomatic, severe native aortic stenosis who are considered intermediate or l ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Deena Victor
Phone: 713.441.4536
Brief Summary: Obtain safety and effectiveness data to support indication expansion for the Medtronic TAVR System to include patients with moderate, symptomatic AS. Detailed Description: Multi-center, international, prospective, randomized ... Read more >
Status: Open Not Enrolling
Investigator: Alpesh Shah
Study Coordinator:
Phone:
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in patients with multi ... Read more >
Status: Open Not Enrolling
Investigator: Sherif Nagueh
Study Coordinator: Sohaib Mhaidi
Phone: 346.238.6402
Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young. It is characterized by unexplained left ventricular hypertrophy (LVH), diffuse and patchy fibros ... Read more >
Status: Open Not Enrolling
Investigator: Mahwash Kassi
Study Coordinator: Jan-Michael Ragunton
Phone: 346.238.0218
This study will evaluate the efficacy and safety of vutrisiran 25 mg administered subcutaneously (SC) once every 3 months (q3M) compared to placebo in patients with ATTR amyloidosis with cardiomyopathy. ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Padmaja Naik
Phone: 713.441.7386
The purpose of this study is to assess if using the Impella® CP (or Impella® 2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart function and health after a heart p ... Read more >
Status: Enrolling
Investigator: Ross Reul
Study Coordinator: Deena Victor
Phone: 713.441.4536
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or syst ... Read more >
Status: Enrolling
Investigator: Sachin Goel
Study Coordinator: Tia McGaughy
Phone: 346.238.4576
Brief Summary: The objective of this randomized controlled trial (RCT) is to compare the clinical outcome of MitraClip™ device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve ha ... Read more >
Status: Open Not Enrolling
Investigator: Khurram Nasir
Study Coordinator: Zulqarnain Javed
Phone: 346.356.1481
In this comparative effectiveness trial, the aim of this study is to answer the research question of whether a remote blood pressure (BP) management program (RBPM, inclusive of home BP monitoring and telehealth visits with a nurse or pharmacist) ... Read more >
Status: Enrolling
Investigator: Rayan Yousefzai
Study Coordinator: Jan-Michael Ragunton
Phone: 346.238.0218
Characterize the impact of pulmonary artery denervation on the quality of life in Heart Failure Patients with Group 2 Pulmonary Hypertension ... Read more >
Status: Enrolling
Investigator: Alpesh Shah
Study Coordinator: Padmaja Naik
Phone: 713.441.7386
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be ... Read more >
Status: Open Not Enrolling
Investigator: Maham Rahimi
Study Coordinator: Sohaib Mhaidi
Phone: 346.238.6402
This is a multi-surgeon monocentric study at Houston Methodist Hospital (HMH) to decrease the number of groin wound complications using BIASURGE Advanced Surgical Solution (BIASURGE) after common femoral artery exposure for vascular surgery proc ... Read more >
Status: Open Not Enrolling
Investigator: Neal Kleiman
Study Coordinator: Tia McGaughy
Phone: 346.238.4576
The purpose of the study is to investigate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic Aortic Stenosis (AS) at intermediate surgical risk by randomizing patients to either Surgic ... Read more >
Status: Enrolling
Investigator: Michael Reardon
Study Coordinator: Yejide Oyewole
Phone: 346.238.2294
Brief Summary: To collect information about treatment for symptomatic severe Aortic Regurgitation (AR), which affects the aortic valve in the heart. Aortic regurgitation is a condition where aortic valve in the heart does not close tightly and ... Read more >
Status: Enrolling
Investigator: Neal Kleiman
Study Coordinator: Tia McGaughy
Phone: 346.238.4576
Brief Summary: Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device. Inclusion Criteria: Moderate to severe or severe symptomatic mitral regurgitation Loca ... Read more >
Status: Enrolling
Investigator: Sachin Goel
Study Coordinator: Yejide Oyewole
Phone: 346.238.2294
This is a prospective multicenter clinical investigation designed to evaluate the safety and effectiveness of the TricValve® Transcatheter Bicaval Valve System for improving outcomes in symptomatic subjects with severe TR deemed by the local Hea ... Read more >
Status: Open Not Enrolling
Investigator: Stephen Little
Study Coordinator: Padmaja Naik
Phone: 713.441.7386
Brief Summary: The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or ... Read more >
Status: Enrolling
Investigator: Sachin Goel
Study Coordinator: Tia McGaughy
Phone: 346.238.4576
Brief Summary: The objective of this early feasibility study is to gain early clinical insight into the performance of the Intrepid transcatheter tricuspid valve replacement (TTVR) system intended for transfemoral access to deliver a self-expan ... Read more >