Xian Li Download Headshot

Xian Chang Li, MD, PhD

  • Transplant Research Chair, Houston Methodist Immunobiology & Transplant Science Center
  • Professor of Transplant Immunology in Surgery, Houston Methodist Research Institute
  • Director, Houston Methodist Immunobiology & Transplant Science Center
  • Vice Chair of Research, Houston Methodist Hospital Department of Surgery
  • Max and Lillie Frosch Centennial Chair in Transplant Research, Houston Methodist Immunobiology & Transplant Science Center 
Media Contact: Lisa Merkl , 832.667.5916

Xian Chang Li, MD, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Allograft rejection
  • Clinical translation of basic discoveries into biotherapeutics
  • Developing new therapeutics to treat diseases caused by abnormal immune responses, such as diabetes, lupus, arthritis and multiple sclerosis
  • Immunology
  • Immunotherapeutics
  • Improve transplant outcomes & success
  • Regulatory cell function
  • Tolerance induction
  • Translation of basic science into clinical therapies
  • Translational immunology
  • Transplant
  • Transplant biology

Credentials

Postdoctoral Fellowship, University of Toronto
Postdoctoral Fellowship, Harvard University
MD, Qingdao Medical School, Qingdao, China
Research Fellowship, University of Western Ontario
PhD, Western University, London, Canada

Publications

Transplantation for Peri-Hilar and Intrahepatic Cholangiocarcinoma With mTOR Immunosuppression
Semaan, S, Connor, AA, Saharia, A, Kodali, S, Elaileh, A, Patel, K, Soliman, N, Basra, T, Victor, DW, Simon, CJ, Cheah, YL, Hobeika, MJ, Mobley, CM, Dhingra, S, Schwartz, MR, Maqsood, A, Heyne, K, Abdelrahim, M, Li, XC, Javle, M, Vauthey, JN, Gaber, AO & Ghobrial, RM 2025, , Transplantation Proceedings, vol. 57, no. 2, pp. 255-263. https://doi.org/10.1016/j.transproceed.2025.02.001

Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models
Xiao, X, Du, Y, Sun, S, Su, X, Xing, J, Wang, G, Elzein, SM, Zou, D, Minze, LJ, Mao, Z, Ghobrial, RM, Connor, AA, Chen, W, Zhang, Z & Li, XC 2025, , Journal of Clinical Investigation, vol. 135, no. 4, e183671. https://doi.org/10.1172/JCI183671

Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models
Xiao, X, Du, Y, Sun, S, Su, X, Xing, J, Wang, G, Elzein, SM, Zou, D, Minze, LJ, Mao, Z, Ghobrial, RM, Connor, AA, Chen, W, Zhang, Z & Li, XC 2024, , The Journal of clinical investigation, vol. 135, no. 4, e183671. https://doi.org/10.1172/JCI183671, https://doi.org/10.1172/JCI183671


Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization
Connor, AA, Adelman, MW, Mobley, CM, Moaddab, M, Erhardt, AJ, Hsu, DE, Brombosz, EW, Sanghvi, M, Lee Cheah, Y, Simon, CJ, Hobeika, MJ, Saharia, AS, Victor, DW, Kodali, S, Basra, T, Graviss, EA, Nguyen, DT, Elsaiey, A, Moore, LW, Nigo, M, Drews, AL, Grimes, KA, Arias, CA, Li, XC, Gaber, AO & Ghobrial, RM 2024, , Transplantation Direct, vol. 10, no. 4, pp. E1590. https://doi.org/10.1097/TXD.0000000000001590

Molecular Profiling of Cholangiocarcinoma Peri-Liver Transplantation Informs Precision Approaches
Connor, AA, Mattohti, M, Kodali, S, Abdelrahim, M, Elaileh, A, Sanghvi, M, Saharia, A, Hobeika, MJ, Mobley, CM, Cheah, YL, Simon, CJ, Victor, III, DW, Basra, T, Maqsood, A, Heyne, K, Divatia, M, Dhingra, S, Schwartz, M, Moore, LW, Brombosz, EW, Javle, M, Vauthey, JN, Li, XC, Gaber, AO & Ghobrial, RM 2024, , American Journal of Transplantation, vol. 24, no. 1, pp. S64-S64.

CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D, Yin, Z, Yi, SG, Wang, G, Guo, Y, Xiao, X, Li, S, Zhang, X, Gonzalez, NM, Minze, LJ, Wang, L, Wong, STC, Osama Gaber, A, Ghobrial, RM, Li, XC & Chen, W 2024, , Nature immunology, vol. 25, no. 1, pp. 66-76. https://doi.org/10.1038/s41590-023-01682-z

The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells
Yan, H, Dai, Y, Zhang, X, Zhang, H, Xiao, X, Fu, J, Zou, D, Yu, A, Jiang, T, Li, XC, Zhao, Z & Chen, W 2023, , iScience, vol. 26, no. 11, 108087. https://doi.org/10.1016/j.isci.2023.108087

Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8+ T Cell Immunity against Tumor
Yu, A, Fu, J, Yin, Z, Yan, H, Xiao, X, Zou, D, Zhang, X, Zu, X, Li, XC & Chen, W 2023, , Research, vol. 6, 0271. https://doi.org/10.34133/research.0271

Automation of Banff rules for precision diagnosis
Mengel, M & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 9, pp. 1284-1285. https://doi.org/10.1016/j.ajt.2023.07.005


Local progenitor-like T cells sustain graft-versus-host disease
Wang, J & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 7, pp. 871-872. https://doi.org/10.1016/j.ajt.2023.05.008

Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells
Chu, X, Xiao, X, Wang, G, Uosef, A, Lou, X, Arnold, P, Wang, Y, Kong, G, Wen, M, Minze, LJ & Li, XC 2023, , Cell Death and Disease, vol. 14, no. 7, 469. https://doi.org/10.1038/s41419-023-06013-6

Natural killer cells are under new Nogo control
Cao, R & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 6, pp. 700-701. https://doi.org/10.1016/j.ajt.2023.04.011

T cells: Surviving a decade of cell proliferation in vivo
Chen, W & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 5, pp. 593-594. https://doi.org/10.1016/j.ajt.2023.03.024

TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions
Lou, X, Ma, B, Zhuang, Y, Xiao, X, Minze, LJ, Xing, J, Zhang, Z & Li, XC 2023, , Computational and Structural Biotechnology Journal, vol. 21, pp. 2801-2808. https://doi.org/10.1016/j.csbj.2023.04.022

Graft-resident donor macrophages functionally regulate transplant outcomes
Su, X & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 4, pp. 455-456. https://doi.org/10.1016/j.ajt.2023.02.018

Targeting the lymph nodes to promote transplant survival
Krummey, SM & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 3, pp. 307-308. https://doi.org/10.1016/j.ajt.2023.01.012

Interleukin-2 and PD-1 synergistically modify T cell exhaustion programs
Cravedi, P & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 2, pp. 161-162. https://doi.org/10.1016/j.ajt.2023.01.002

Multiple human B cell subsets give rise to regulatory B cells
Krummey, SM & Li, XC 2023, , American Journal of Transplantation, vol. 23, no. 1, pp. 3-4. https://doi.org/10.1016/j.ajt.2022.11.010

Languages

  • English