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Stephen T.C. Wong, PhD

  • Professor of Computer Science, Systems Medicine and Bioengineering in Oncology, Houston Methodist Research Institute
  • Associate Director, Cores, Biostatistics and Bioinformatics at the Houston Methodist Cancer Center
  • Houston Methodist computer scientist, bioengineer and systems biologist
  • John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

Stephen T.C. Wong, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Artificial Intelligence (AI)
  • Bioinformatics
  • Biological and medical imaging
  • Clinical neuroscience
  • Digital health
  • Drug combinations
  • Drug discovery
  • Drug repurposing / Drug repositioning
  • Health technology
  • Image-guided therapy
  • Mechanisms of cancer
  • Mechanisms of neurological disorders
  • Molecular imaging
  • Systems biology
  • Translational biophotonics

Credentials

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo

Publications

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors
Ridnour, LA, Cheng, RYS, Kedei, N, Somasundaram, V, Bhattacharyya, DD, Basudhar, D, Wink, AL, Walke, AJ, Kim, C, Heinz, WF, Edmondson, EF, Butcher, DO, Warner, AC, Dorsey, TH, Pore, M, Kinders, RJ, Lipkowitz, S, Bryant, RJ, Rittscher, J, Wong, STC, Hewitt, SM, Chang, JC, Shalaby, A, Callagy, GM, Glynn, SA, Ambs, S, Anderson, SK, McVicar, DW, Lockett, SJ & Wink, DA 2024, , JCI insight, vol. 9, no. 12, e165356. https://doi.org/10.1172/jci.insight.165356

MUSTANG: Multi-sample spatial transcriptomics data analysis with cross-sample transcriptional similarity guidance
Niyakan, S, Sheng, J, Cao, Y, Zhang, X, Xu, Z, Wu, L, Wong, STC & Qian, X 2024, , Patterns, vol. 5, no. 5, 100986. https://doi.org/10.1016/j.patter.2024.100986

Therapeutic drug monitoring in inflammatory bowel disease patients on vedolizumab
Ansari, M, Glassner, K, Irani, M, Saleh, A, Wang, L, Ezeana, C, Wong, S, Perry, C & Abraham, B 2024, , Journal of Digestive Diseases, vol. 25, no. 2, pp. 91-99. https://doi.org/10.1111/1751-2980.13261

Prevalence of Delirium After Abdominal Surgery and Association With Ketamine: A Retrospective, Propensity-Matched Cohort Study
Faisal, H, Qamar, F, Hsu, ES, Xu, J, Lai, EC, Wong, ST & Masud, FN 2024, , Critical care explorations, vol. 6, no. 1, pp. E1032. https://doi.org/10.1097/CCE.0000000000001032

CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D, Yin, Z, Yi, SG, Wang, G, Guo, Y, Xiao, X, Li, S, Zhang, X, Gonzalez, NM, Minze, LJ, Wang, L, Wong, STC, Osama Gaber, A, Ghobrial, RM, Li, XC & Chen, W 2024, , Nature immunology, vol. 25, no. 1, pp. 66-76. https://doi.org/10.1038/s41590-023-01682-z

Label-free optical imaging for brain cancer assessment
Raghunathan, R, Vasquez, M, Zhang, K, Zhao, H & Wong, STC 2024, , Trends in Cancer, vol. 10, no. 6, pp. 557-570. https://doi.org/10.1016/j.trecan.2024.03.005

Digital neurology: Personalizing diagnosis and treatment
Hodics, TM, Cole, D, Volpi, JJ, Wong, ST, Derry, PJ & Kent, TA 2024, . in Comprehensive Precision Medicine, First Edition, Volume 1-2. vol. 1, Elsevier, pp. 607-617. https://doi.org/10.1016/B978-0-12-824010-6.00078-2

Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease
Collu, R, Yin, Z, Giunti, E, Daley, S, Chen, M, Morin, P, Killick, R, Wong, STC & Xia, W 2024, , Frontiers in Aging Neuroscience, vol. 16, 1323563. https://doi.org/10.3389/fnagi.2024.1323563

Usability and Tolerability of Virtual Reality-Based Cognitive Stimulation in Healthy Elderly Volunteers—A Feasibility Clinical Trial
Faisal, H, Lim, W, Dattagupta, A, Lin, P, Gupta, R, Lai, EC, Xu, J, Wong, ST & Masud, FN 2024, , Games for Health Journal. https://doi.org/10.1089/g4h.2024.0039

Life-Course Brain Health as a Determinant of Late-Life Mental Health: American Association for Geriatric Psychiatry Expert Panel Recommendations
Eyre, HA, Stirland, LE, Jeste, DV, Reynolds, CF, Berk, M, Ibanez, A, Dawson, WD, Lawlor, B, Leroi, I, Yaffe, K, Gatchel, JR, Karp, JF, Newhouse, P, Rosand, J, Letourneau, N, Bayen, E, Farina, F, Booi, L, Devanand, DP, Mintzer, J, Madigan, S, Jayapurwala, I, Wong, STC, Falcoa, VP, Cummings, JL, Reichman, W, Lock, SL, Bennett, M, Ahuja, R, Steffens, DC, Elkind, MSV & Lavretsky, H 2023, , American Journal of Geriatric Psychiatry, vol. 31, no. 12, pp. 1017-1031. https://doi.org/10.1016/j.jagp.2023.09.013



A Deep Learning Decision Support Tool to Improve Risk Stratification and Reduce Unnecessary Biopsies in BI-RADS 4 Mammograms
Ezeana, CF, He, T, Patel, TA, Kaklamani, V, Elmi, M, Brigmon, E, Otto, PM, Kist, KA, Speck, H, Wang, L, Ensor, J, Shih, YCT, Kim, B, Pan, IW, Cohen, AL, Kelley, K, Spak, D, Yang, WT, Chang, JC & Wong, STC 2023, , Radiology: Artificial Intelligence, vol. 5, no. 6, e220259, pp. e220259. https://doi.org/10.1148/ryai.220259



Generation of Whole Brain Net Water Uptake Map Using Non-contrast Computed Tomography
Wong, K, Hodics, T, Ghosh, R, Volpi, JJ & Wong, ST 2023, , 15th World Stroke Congress, Toronto, Canada, 10/10/23 - 10/12/23.

Artificial Intelligence-Powered Acoustic Analysis System for Dysarthria Severity Assessment
Zhang, Z, Shang, X, Yang, LZ, Ai, W, Wang, J, Wang, H, Wong, STC, Wang, X & Li, H 2023, , Advanced Intelligent Systems, vol. 5, no. 10, 2300097. https://doi.org/10.1002/aisy.202300097

The promise of digital healthcare technologies
Wong, ST, Yeung, AWK, Torkamani, A, Butte, AJ, Glicksberg, BS, Schuller, B, Rodriquez, B, Ting, DSW, Bates, D, Schaden, E, Peng, H, Willschke, H, van der Laak, J, Car, J, Rahimi, K, Celi, LA, Banach, M, Kletecka-Pulker, M, Kimberger, O, Eils, R, Eyre, HA, Shariful Islam, SM, Wong, TY, Gao, W, Brunak, S & Atanasov, AG 2023, , Biotechnology Advances, vol. 11, 1196596, pp. 1196596. https://doi.org/10.3389/fpubh.2023.1196596

BBox-Guided Segmentor: Leveraging expert knowledge for accurate stroke lesion segmentation using weakly supervised bounding box prior
Ou, Y, Huang, SX, Wong, KK, Cummock, J, Volpi, J, Wang, JZ & Wong, ST 2023, , Computerized Medical Imaging and Graphics, vol. 107, 102236, pp. 102236. https://doi.org/10.1016/j.compmedimag.2023.102236

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
Cheng, RYS, Ridnour, LA, Wink, AL, Gonzalez, AL, Femino, EL, Rittscher, H, Somasundaram, V, Heinz, WF, Coutinho, L, Rangel, MC, Edmondson, EF, Butcher, D, Kinders, RJ, Li, X, Wong, STC, McVicar, DW, Anderson, SK, Pore, M, Hewitt, SM, Billiar, TR, Glynn, SA, Chang, JC, Lockett, SJ, Ambs, S & Wink, DA 2023, , Cell Death and Disease, vol. 14, no. 5, 319, pp. 319. https://doi.org/10.1038/s41419-023-05834-9

Languages

  • English
  • Chinese (Mandarin, Cantonese, Taiwanese)
  • Japanese (limited)