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Stephen T.C. Wong, PhD

  • Professor of Computer Science, Systems Medicine and Bioengineering in Oncology, Houston Methodist Research Institute
  • Associate Director, Cores, Biostatistics and Bioinformatics at the Houston Methodist Cancer Center
  • Houston Methodist computer scientist, bioengineer and systems biologist
  • John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

Stephen T.C. Wong, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Artificial Intelligence (AI)
  • Bioinformatics
  • Biological and medical imaging
  • Clinical neuroscience
  • Digital health
  • Drug combinations
  • Drug discovery
  • Drug repurposing / Drug repositioning
  • Health technology
  • Image-guided therapy
  • Mechanisms of cancer
  • Mechanisms of neurological disorders
  • Molecular imaging
  • Systems biology
  • Translational biophotonics

Credentials

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo

Publications

Systems immunology insights into brain metastasis
Dong, W, Sheng, J, Cui, JZM, Zhao, H & Wong, STC 2024, , Trends in Immunology, vol. 45, no. 11, pp. 903-916. https://doi.org/10.1016/j.it.2024.09.010


Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer
Ridnour, LA, Heinz, WF, Cheng, RYS, Wink, AL, Kedei, N, Pore, M, Imtiaz, F, Femino, EL, Gonzalez, AL, Coutinho, LL, Moffat, RL, Butcher, D, Edmondson, EF, Li, X, Rangel, MC, Kinders, RJ, Rittscher, J, Lipkowitz, S, Wong, STC, Anderson, SK, McVicar, DW, Glynn, SA, Billiar, TR, Chang, JC, Hewitt, SM, Ambs, S, Lockett, SJ & Wink, DA 2024, , Cancer research communications, vol. 4, no. 10, pp. 2766-2782. https://doi.org/10.1158/2767-9764.CRC-24-0235

Correction: VAM abstracts 2024 - batch 3 - IP001 through IP201 (Journal of Vascular Surgery (2024) 79(6), (S0741521424006414))
Ghosh, R, Wong, K, Yaeger, KA, Britz, G, Avazmohammadi, R & Wong, ST 2024, , Journal of Vascular Surgery, vol. 80, no. 4, pp. 1316. https://doi.org/10.1016/j.jvs.2024.07.001


Excessive Phosphatidylethanolamine Flux in Obesity: A Catalyst for Alzheimer's Disease and Cancer Progression
Wong, ST 2024, , Alzheimers Association, Philadelphia, United States, 7/29/24 - 8/1/24.


Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors
Ridnour, LA, Cheng, RYS, Kedei, N, Somasundaram, V, Bhattacharyya, DD, Basudhar, D, Wink, AL, Walke, AJ, Kim, C, Heinz, WF, Edmondson, EF, Butcher, DO, Warner, AC, Dorsey, TH, Pore, M, Kinders, RJ, Lipkowitz, S, Bryant, RJ, Rittscher, J, Wong, STC, Hewitt, SM, Chang, JC, Shalaby, A, Callagy, GM, Glynn, SA, Ambs, S, Anderson, SK, McVicar, DW, Lockett, SJ & Wink, DA 2024, , JCI insight, vol. 9, no. 12, e165356. https://doi.org/10.1172/jci.insight.165356

MUSTANG: Multi-sample spatial transcriptomics data analysis with cross-sample transcriptional similarity guidance
Niyakan, S, Sheng, J, Cao, Y, Zhang, X, Xu, Z, Wu, L, Wong, STC & Qian, X 2024, , Patterns, vol. 5, no. 5, 100986. https://doi.org/10.1016/j.patter.2024.100986

An on-line deep learning decision support tool, iBRISK, aimed at improving breast cancer risk estimation and reducing unnecessary biopsies for BI-RADS 4 patients
Wong, ST, Ezeana, CF, Yu, X, Cheng He, T, Patel, T, Kaklamani, VG & Chang, JC 2024, . in Proceedings: San Antonio Breast Cancer Symposium 2023. vol. 84, AACR Annual Meeting, San Diego, United States, 4/5/24. https://doi.org/10.1158/1538-7445.SABCS23-PO2-28-06

Therapeutic drug monitoring in inflammatory bowel disease patients on vedolizumab
Ansari, M, Glassner, K, Irani, M, Saleh, A, Wang, L, Ezeana, C, Wong, S, Perry, C & Abraham, B 2024, , Journal of Digestive Diseases, vol. 25, no. 2, pp. 91-99. https://doi.org/10.1111/1751-2980.13261

Prevalence of Delirium After Abdominal Surgery and Association With Ketamine: A Retrospective, Propensity-Matched Cohort Study
Faisal, H, Qamar, F, Hsu, ES, Xu, J, Lai, EC, Wong, ST & Masud, FN 2024, , Critical care explorations, vol. 6, no. 1, pp. E1032. https://doi.org/10.1097/CCE.0000000000001032

CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D, Yin, Z, Yi, SG, Wang, G, Guo, Y, Xiao, X, Li, S, Zhang, X, Gonzalez, NM, Minze, LJ, Wang, L, Wong, STC, Osama Gaber, A, Ghobrial, RM, Li, XC & Chen, W 2024, , Nature immunology, vol. 25, no. 1, pp. 66-76. https://doi.org/10.1038/s41590-023-01682-z

Label-free optical imaging for brain cancer assessment
Raghunathan, R, Vasquez, M, Zhang, K, Zhao, H & Wong, STC 2024, , Trends in Cancer, vol. 10, no. 6, pp. 557-570. https://doi.org/10.1016/j.trecan.2024.03.005

Digital neurology: Personalizing diagnosis and treatment
Hodics, TM, Cole, D, Volpi, JJ, Wong, ST, Derry, PJ & Kent, TA 2024, . in Comprehensive Precision Medicine, First Edition, Volume 1-2. vol. 1, Elsevier, pp. 607-617. https://doi.org/10.1016/B978-0-12-824010-6.00078-2

Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease
Collu, R, Yin, Z, Giunti, E, Daley, S, Chen, M, Morin, P, Killick, R, Wong, STC & Xia, W 2024, , Frontiers in Aging Neuroscience, vol. 16, 1323563. https://doi.org/10.3389/fnagi.2024.1323563

Usability and Tolerability of Virtual Reality-Based Cognitive Stimulation in Healthy Elderly Volunteers—A Feasibility Clinical Trial
Faisal, H, Lim, W, Dattagupta, A, Lin, P, Gupta, R, Lai, EC, Xu, J, Wong, ST & Masud, FN 2024, , Games for Health Journal. https://doi.org/10.1089/g4h.2024.0039

Frozen Large-scale Pretrained Vision-Language Models are the Effective Foundational Backbone for Multimodal Breast Cancer Prediction
Vo, HQ, Wang, L, Wong, K, Ezeana, CF, Yu, X, Yang, W, Chang, JC, Nguyen, HV & Wong, ST 2024, , IEEE Journal of Biomedical and Health Informatics, pp. 1-14. https://doi.org/10.1109/JBHI.2024.3507638

Life-Course Brain Health as a Determinant of Late-Life Mental Health: American Association for Geriatric Psychiatry Expert Panel Recommendations
Eyre, HA, Stirland, LE, Jeste, DV, Reynolds, CF, Berk, M, Ibanez, A, Dawson, WD, Lawlor, B, Leroi, I, Yaffe, K, Gatchel, JR, Karp, JF, Newhouse, P, Rosand, J, Letourneau, N, Bayen, E, Farina, F, Booi, L, Devanand, DP, Mintzer, J, Madigan, S, Jayapurwala, I, Wong, STC, Falcoa, VP, Cummings, JL, Reichman, W, Lock, SL, Bennett, M, Ahuja, R, Steffens, DC, Elkind, MSV & Lavretsky, H 2023, , American Journal of Geriatric Psychiatry, vol. 31, no. 12, pp. 1017-1031. https://doi.org/10.1016/j.jagp.2023.09.013


Languages

  • English
  • Chinese (Mandarin, Cantonese, Taiwanese)
  • Japanese (limited)