Stanley Appel Download Headshot

Stanley H. Appel, MD

  • Houston Methodist neurologist
  • Houston Methodist Neurological Institute co-director
  • Chairman of the Stanley H. Appel Department of Neurology at Houston Methodist Hospital
  • Peggy and Gary Edwards Distinguished Endowed Chair in ALS Research at Houston Methodist Hospital
  • Professor of neurology, Weill Cornell Medical College
  • Adjunct professor, Texas A&M Health Science Center College of Medicine
Media Contact: Patti Muck , 832.667.5740

Stanley H. Appel, MD

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Media Contact: Patti Muck , 832.667.5740

Areas of Expertise

  • Amyotrophic lateral sclerosis (ALS)
  • Alzheimer’s disease
  • Inflammatory neuropathies (CIDP)
  • Neuromuscular disease
  • Parkinson’s disease
  • Multiple system atrophy

Credentials

BOARD CERTIFICATION
Neurology | American Board of Psychiatry and Neurology
MEDICAL SCHOOL
Columbia University College of Physicians and Surgeons - New York, NY | 1960
INTERNSHIP
Massachusetts General Hospital - Boston, MA
RESIDENCY
Neurology | Mount Sinai Medical Center - Miami Beach, FL
RESEARCH FELLOWSHIP
Duke University Medical Center - Durham, NC

Publications


A phase 1 proof-of-concept study evaluating safety, tolerability, and biological marker responses with combination therapy of CTLA4-Ig and interleukin-2 in amyotrophic lateral sclerosis
Thonhoff, JR, Beers, DR, Zhao, W, Faridar, A, Thome, A, Wen, S, Zhang, A, Wang, J & Appel, SH 2024, , Frontiers in Neurology, vol. 15, 1415106, pp. 1415106. https://doi.org/10.3389/fneur.2024.1415106

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, 54, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, pp. 54. https://doi.org/10.1186/s40035-023-00387-5


Primary visual cortex pathology in ALS patients with C9ORF72 expansion
Cykowski, MD, Arumanayagam, AS, Powell, SZ & Appel, SH 2024, , Brain Pathology, vol. 34, no. 5, e13229. https://doi.org/10.1111/bpa.13229

Neuroinflammation co-localizes highly with tau in amnestic mild cognitive impairment
Appleton, J, Funk, Q, Bradbury, K, Yu, M, Faridar, A, Beers, D, Appel, SH, Fujita, M, Masdeu, JC & Pascual, B 2022, , Alzheimers and Dementia, vol. 18, no. S1, e068025. https://doi.org/10.1002/alz.068025

Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, JR, Berry, JD, Macklin, EA, Beers, DR, Mendoza, PA, Zhao, W, Thome, AD, Triolo, F, Moon, JJ, Paganoni, S, Cudkowicz, M & Appel, SH 2022, , Neurology: Neuroimmunology and NeuroInflammation, vol. 9, no. 6, e200019. https://doi.org/10.1212/NXI.0000000000200019

Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A, Vasquez, M, Thome, AD, Yin, Z, Xuan, H, Wang, JH, Wen, S, Li, X, Thonhoff, JR, Zhao, W, Zhao, H, Beers, DR, Wong, STC, Masdeu, JC & Appel, SH 2022, , Acta Neuropathologica Communications, vol. 10, no. 1, 144. https://doi.org/10.1186/s40478-022-01447-z

Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, AD, Thonhoff, JR, Zhao, W, Faridar, A, Wang, J, Beers, DR & Appel, SH 2022, , Frontiers in immunology, vol. 13, 875825, pp. 875825. https://doi.org/10.3389/fimmu.2022.875825

Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
for the Healey ALS Platform Trial Study Group, HEALEY ALS Platform Trial Study Group, Biostatisticians, Investigators, Clinical Operations Team & Medical Monitors 2022, , Annals of Neurology, vol. 91, no. 2, pp. 165-175. https://doi.org/10.1002/ana.26285

Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS
Beers, DR, Thonhoff, JR, Faridar, A, Thome, AD, Zhao, W, Wen, S & Appel, SH 2022, , Annals of Neurology, vol. 92, no. 2, pp. 195-200. https://doi.org/10.1002/ana.26375


The role of inflammation in neurodegenerative diseases
Appel, SH, Beers, DR & Zhao, W 2022, . in Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. Elsevier, pp. 403-421. https://doi.org/10.1016/B978-0-323-85654-6.00036-8


Beneficial effects of transplanted human bone marrow endothelial progenitors on functional and cellular components of blood-spinal cord barrier in ALSMice
Garbuzova-Davis, S, Boccio, KJ, Llauget, A, Shell, R, Hailu, S, Mustafa, H, Ehrhart, J, Sanberg, PR, Appel, SH & Borlongan, CV 2021, , eNeuro, vol. 8, no. 5, ENEURO.0314-21.2021. https://doi.org/10.1523/ENEURO.0314-21.2021

Fast progression in amyotrophic lateral sclerosis is associated with greater tdp-43 burden in spinal cord
Cathcart, SJ, Appel, SH, Peterson, LE, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 8, pp. 754-763. https://doi.org/10.1093/jnen/nlab061

Radicava/Edaravone Findings in Biomarkers From Amyotrophic Lateral Sclerosis (REFINE-ALS): Protocol and Study Design
Berry, J, Brooks, B, Genge, A, Heiman-Patterson, T, Appel, S, Benatar, M, Bowser, R, Cudkowicz, M, Gooch, C, Shefner, J, Westra, J, Agnese, W, Merrill, C, Nelson, S & Apple, S 2021, , Neurology: Clinical Practice, vol. 11, no. 4, pp. E472-E479. https://doi.org/10.1212/CPJ.0000000000000968

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, AD, Atassi, F, Wang, J, Faridar, A, Zhao, W, Thonhoff, JR, Beers, DR, Lai, EC & Appel, SH 2021, , npj Parkinsons Disease, vol. 7, no. 1, 41, pp. 41. https://doi.org/10.1038/s41531-021-00188-5

Detection of endothelial cell-associated human DNA reveals transplanted human bone marrow stem cell engraftment into CNS capillaries of ALS mice
Garbuzova-Davis, S, Boccio, KJ, Ehrhart, J, Sanberg, PR, Appel, SH & Borlongan, CV 2021, , Brain Research Bulletin, vol. 170, pp. 22-28. https://doi.org/10.1016/j.brainresbull.2021.01.020

Languages

  • English