Robert C. Krencik, PhD

  • Neuroscientist, Houston Methodist Research Institute
  • Assistant Professor of Neurosurgery, Houston Methodist Hospital Department of Neurosurgery
  • Assistant Professor of Neuroscience in Neurological Surgery, Houston Methodist Research Institute
  • Principle Investigator, Houston Methodist Neurological Institute Center for Neuroregeneration Astrocellular Therapeutics Lab

Robert C. Krencik, PhD

Areas of Expertise

  • Astrocellular therapeutics
  • Astrocytes
  • Astroplasticity
  • Disease modeling
  • Mini-brains
  • Neural stem cells
  • Neuron-Glia interactions
  • Neuroregeneration
  • Neuroscience
  • Physiology
  • Repairing brain function
  • Spinal cord injury
  • Stem cells
  • Translational medicine

Credentials

PhD, University of Wisconsin-Madison
BS, Indiana University Bloomington
MS, Iowa State University

Publications

Biofabrication of Neural Organoids: An Experiential Learning Approach for Instructional Laboratories
Cvetkovic, C, Lindley, S, Golecki, H & Krencik, R 2024, , Biomedical Engineering Education, vol. 4, no. 2, pp. 409-419. https://doi.org/10.1007/s43683-024-00145-7

Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids
Lavekar , S, Patel, M, Montalvo Parra, MD & Krencik, RC 2023, , Frontiers in Neuroscience, vol. 17, 1305921, pp. 1305921. https://doi.org/10.3389/fnins.2023.1305921

Machine learning dissection of human accelerated regions in primate neurodevelopment
Whalen, S, Inoue, F, Ryu, H, Fair, T, Markenscoff-Papadimitriou, E, Keough, K, Kircher, M, Martin, B, Alvarado, B, Elor, O, Laboy Cintron, D, Williams, A, Hassan Samee, MA, Thomas, S, Krencik, R, Ullian, EM, Kriegstein, A, Rubenstein, JL, Shendure, J, Pollen, AA, Ahituv, N & Pollard, KS 2023, , Neuron, vol. 111, no. 6, pp. 857-873.e8. https://doi.org/10.1016/j.neuron.2022.12.026

Human Midbrain Organoids to Unravel Astrocyte Lipid Dysregulation in Parkinson’s Disease
Tahanis, A, Nguyen, T, Patel, M, Oji, S & Krencik, RC 2023, , Neuroscience 2023: Annual Meeting of the Society for Neuroscience, Washington, D.C. United States, 11/11/23 - 11/15/23.

Screening Human Astrocyte Matrisome Components upon Synaptic Networks within Neural Organoids
Patel, M, Aghlara-Fotovat, S, Lavekar , S, Nasr Esfahani, S, Oji, S, Horner, PJ, Veiseh, O & Krencik, RC 2023, , Neuroscience 2023: Annual Meeting of the Society for Neuroscience, Washington, D.C. United States, 11/11/23 - 11/15/23.

AstroCapsules: A Novel Tool to Detect and Modulate the Neurotrauma Microenvironment
Aghlara-Fotovat, S, Rosner, K, Montalvo Parra, MD, Veiseh, O & Krencik, RC 2023, , Mission Connect Symposium 2023, 11/17/23.

Screening Human Astrocyte Matrisome Components upon Synaptic Networks within Neural Organoids
Patel, M, Aghlara-Fotovat, S, Lavekar , S, Nasr Esfahani, S, Oji, S, Horner, PJ, Veiseh, O & Krencik, RC 2023, , Mission Connect Symposium 2023, 11/17/23.

Human Astrocyte Lipid Trafficking Dysregulation In Parkinson’s Disease
Tahanis, A, Nguyen, T & Krencik, RC 2023, , 148th American Neurological Association annual meeting, Philadelphia, United States, 9/9/23 - 9/12/23.

Expansion microscopy to Investigate Human Astrocyte Reactivity within Organoids
Lavekar , S, Patel, M, Oji, S & Krencik, RC 2023, , Houston Methodist Summer Science Symposium, 8/4/23.

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment
Whalen, S, Inoue, F, Ryu, H, Fairr, T, Markenscoff-Papadimitriou, E, Keough, K, Kircher, M, Martin, B, Alvarado, B, Elor, O, Cintron, D, Williams, A, Samee, MAH, Thomas, S, Krencik, RC, Ullian, E, Kriegstein, A, Rubenstein, J, Shendure, J, Pollen, A, Ahituv, N & Pollard, K 2022, , bioRxiv.

Assessing Gq-GPCR–induced human astrocyte reactivity using bioengineered neural organoids
Cvetkovic, C, Patel, R, Shetty, A, Hogan, MK, Anderson, M, Basu, N, Aghlara-Fotovat, S, Ramesh, S, Sardar, D, Veiseh, O, Ward, ME, Deneen, B, Horner, PJ & Krencik, R 2022, , Journal of Cell Biology, vol. 221, no. 4, e202107135. https://doi.org/10.1083/jcb.202107135

Dissecting Human Astrocyte Extracellular Signaling within the Neuroinflammatory Microenvironment
Krencik, RC 2021, , Mission Connect Annual Scientific Symposium 2021, 11/12/21.

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Sadaf, H, Desai, VR, Misra, V, Golanov, E, Hegde, ML, Villapol, S, Karmonik, C, Regnier-Golanov, A, Sayenko, D, Horner, PJ, Krencik, R, Weng, YL, Vahidy, FS & Britz, GW 2021, , Annals of Clinical and Translational Neurology. https://doi.org/10.1002/acn3.51443

Uncovering Extracellular Mechanisms of Astrocyte-Dependent Neurodegeneration in Parkinson's Disease
Krencik, RC 2021, , 2021 MAPTA Summer Science Symposium, Houston, United States, 8/5/21 - 8/6/21.

NEUROSOME/ASTROSOME COMPOSITIONS AND METHODS OF USE
Krencik, RC May. 14 2021, , Patent No. WO2021091582.

Mapping astrocyte transcriptional signatures in response to neuroactive compounds
Sardar, D, Lozzi, B, Woo, J, Huang, TW, Cvetkovic, C, Creighton, CJ, Krencik, R & Deneen, B 2021, , International journal of molecular sciences, vol. 22, no. 8, 3975. https://doi.org/10.3390/ijms22083975

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Zhang, N, Bewick, B, Schultz, J, Tiwari, A, Krencik, R, Zhang, A, Adachi, K, Xia, G, Yun, K, Sarkar, P & Ashizawa, T 2021, , Neurotherapeutics, vol. 18, no. 3, pp. 1710-1728. https://doi.org/10.1007/s13311-021-01075-w

Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies
Aghlara-Fotovat, S, Nash, A, Kim, B, Krencik, R & Veiseh, O 2021, , Drug Delivery and Translational Research, vol. 11, no. 6, pp. 2394-2413. https://doi.org/10.1007/s13346-021-01018-0, https://doi.org/10.1007/s13346-021-01018-0

Humanized Biomimetic Nanovesicles for Neuron Targeting
Zinger, A, Cvetkovic, C, Sushnitha, M, Naoi, T, Baudo, G, Anderson, M, Shetty, A, Basu, N, Covello, J, Tasciotti, E, Amit, M, Xie, T, Taraballi, F & Krencik, R 2021, , Advanced Science, vol. 8, no. 19, 2101437, pp. e2101437. https://doi.org/10.1002/advs.202101437

Targeting the extracellular matrix for immunomodulation: applications in drug delivery and cell therapies
Aghlara-Fotovat, S, Nash, A, Kim, B, Krencik, R & Veiseh, O 2021, , Drug Delivery and Translational Research, vol. 11, no. 6, pp. 2394-2413. https://doi.org/10.1007/s13346-021-01018-0

Languages

  • English