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Philip J. Horner, PhD

  • Professor of Neuroregeneration, Houston Methodist Research Institute
  • Scientific Director, Center for Neuroregeneration, Houston Methodist Neurological Institute, Houston Methodist Research Institute
  • Co-director, Houston Methodist Regenerative & Restorative Neurosurgery, Houston Methodist Research Institute
  • Vice Chairman of Research, Houston Methodist department of neurosurgery
  • Principle Investigator, Houston Methodist Neurological Institute Center for Neuroregeneration Neuroplasticity & Repair Lab
Media Contact: Lisa Merkl , 832.667.5916

Philip J. Horner, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Multiple sclerosis
  • Myelin
  • Neural stem cells
  • Neural trauma
  • Optogenetics
  • Regeneration
  • Spinal cord
  • Stroke

Credentials

Postdoctoral Fellowship, The Salk Institute for Biological Studies
BS, University of Nevada, Reno
PhD, Ohio State University
MS, Ohio State University

Publications

Hemin-Induced Transient Senescence Via DNA Damage Response: A Neuroprotective Mechanism Against Ferroptosis in Intracerebral Hemorrhage
Maloji Rao, VH, Vasquez, V, Kodavati, M, Mitra, J, Provasek, V, Voh, A, Liopo, A, Derry, PJ, Mikheve, A, Rostomily, RC, Horner, PJ, Tour, JM, Britz, GW, Kent, TA & Hegde, M 2024, , Research square. https://doi.org/10.21203/rs.3.rs-4686841/v1

Electrokinetic convection-enhanced delivery for infusion into the brain from a hydrogel reservoir
Cruz-Garza, JG, Bhenderu, LS, Taghlabi, KM, Frazee, KP, Guerrero, JR, Hogan, MK, Humes, F, Rostomily, RC, Horner, PJ & Faraji, AH 2024, , Communications Biology, vol. 7, no. 1, 869. https://doi.org/10.1038/s42003-024-06404-1

A novel minimally invasive and versatile kyphoplasty balloon-based model of porcine spinal cord injury
Barber, SM, Wolfe, T, Steele, AG, Hoffman, K, Hogan, MK, Frazier, A, Tang, X, Sayenko, DG & Horner, PJ 2024, , Frontiers in Neurology, vol. 15, 1422357, pp. 1422357. https://doi.org/10.3389/fneur.2024.1422357

Mapping lumbar efferent and afferent spinal circuitries via paddle array in a porcine model
Steele, AG, Taccola, G, Frazier, AM, Manzella, M, Hogan, M, Horner, PJ, Faraji, AH & Sayenko, DG 2024, , Journal of Neuroscience Methods, vol. 405, 110104, pp. 110104. https://doi.org/10.1016/j.jneumeth.2024.110104

iDISCO Tissue Clearing Whole-Brain and Light Sheet Microscopy for High-Throughput Imaging in a Mouse Model of Traumatic Brain Injury
Flinn, H, Cruz-Pineda, L, Montier, L, Horner, PJ & Villapol, S 2024, . in Methods in Molecular Biology. vol. 2761, Methods in molecular biology (Clifton, N.J.), Humana Press, pp. 589-597. https://doi.org/10.1007/978-1-0716-3662-6_39

Novel site-specific neuromodulation of ventral spinal circuitry coordinating neural control of micturition after semi-chronic spinal cord injury
Salazar, BH, Hoffman, KA, Frazier, AM, Hogan, MK, Khavari, R, Sayenko, D & Horner, PJ 2023, , Scientific Reports.

Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury
Wei, H, Wu, X, Withrow, J, Cuevas-Diaz Duran, R, Singh, S, Chaboub, LS, Rakshit, J, Mejia, J, Rolfe, A, Herrera, JJ, Horner, PJ & Wu, JQ 2023, , Cell Reports, vol. 42, no. 5, 112486. https://doi.org/10.1016/j.celrep.2023.112486

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain
Cruz-Garza, JG, Taghlabi, KM, Bhenderu, LS, Gupta, S, Pandey, A, Frazier, AM, Brisbay, S, Patterson, JD, Salegio, EA, Kantorak, CJ, Karmonik, C, Horner, PJ, Rostomily, RC & Faraji, AH 2023, , Journal of Visualized Experiments, vol. 2023, no. 193, e64079. https://doi.org/10.3791/64079

Rigor and reproducibility in analysis of rodent behavior utilizing the forelimb reaching task following a cervical spinal cord injury
Salazar, BH, Hoffman, KA, Fraizer, AM, Humes, F, Hogan, MK, Horner, MA, Yadegar, T, Trusler, S, Hamilton, GF & Horner, PJ 2023, , Behavioural Brain Research, vol. 439, 114188. https://doi.org/10.1016/j.bbr.2022.114188


Screening Human Astrocyte Matrisome Components upon Synaptic Networks within Neural Organoids
Patel, M, Aghlara-Fotovat, S, Lavekar , S, Nasr Esfahani, S, Oji, S, Horner, PJ, Veiseh, O & Krencik, RC 2023, , Neuroscience 2023: Annual Meeting of the Society for Neuroscience, Washington, D.C. United States, 11/11/23 - 11/15/23.

Screening Human Astrocyte Matrisome Components upon Synaptic Networks within Neural Organoids
Patel, M, Aghlara-Fotovat, S, Lavekar , S, Nasr Esfahani, S, Oji, S, Horner, PJ, Veiseh, O & Krencik, RC 2023, , Mission Connect Symposium 2023, 11/17/23.

Mapping lumbar efferent and afferent spinal circuitries via paddle array in a porcine model
Steele, A, Taccola, G, Dietz, V, Frazier, A, Horner, PJ, Faraji, A & Sayenko, D 2023, , Society for Neuroscience, 11/11/23 - 11/15/23.

Rigor and Reproducibility in Analysis of Rodent Behavior Utilizing the Forelimb Reaching Task Following a Cervical Spinal Cord Injury
Salazar, BH, Hoffman, KA, Fraizer, AM, Humes, F, Hogan, MK, Horner, MA, Yadegar, T, Trusler, S, Hamilton, GF & Horner, PJ 2023, , Behavioural Brain Research, vol. 439, 114188. https://doi.org/10.1016/j.bbr.2022.114188

SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra, J, Kodavati, M, Provasek, VE, Rao, KS, Mitra, S, Hamilton, DJ, Horner, PJ, Vahidy, FS, Britz, GW, Kent, TA & Hegde, ML 2022, , Ageing Research Reviews, vol. 80, 101687. https://doi.org/10.1016/j.arr.2022.101687

Effects of transcutaneous spinal stimulation on spatiotemporal cortical activation patterns: A proof-of-concept EEG study
Steele, AG, Manson, GA, Horner, PJ, Sayenko, DG & Contreras-Vidal, JL 2022, , Journal of neural engineering, vol. 19, no. 4, 046001. https://doi.org/10.1088/1741-2552/ac7b4b

Assessing Gq-GPCR–induced human astrocyte reactivity using bioengineered neural organoids
Cvetkovic, C, Patel, R, Shetty, A, Hogan, MK, Anderson, M, Basu, N, Aghlara-Fotovat, S, Ramesh, S, Sardar, D, Veiseh, O, Ward, ME, Deneen, B, Horner, PJ & Krencik, R 2022, , Journal of Cell Biology, vol. 221, no. 4, e202107135. https://doi.org/10.1083/jcb.202107135

Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive Without Neuroprotection in the Spinal Contusion Cavity
Olmsted, ZT, Stigliano, C, Marzullo, B, Cibelli, J, Horner, PJ & Paluh, JL 2022, , Frontiers in Cellular Neuroscience, vol. 15, 725195, pp. 725195. https://doi.org/10.3389/fncel.2021.725195

Stereotaxic Atlas of the Human Lumbar-Sacral Spinal Cord
Grossman, RG, Tang, X & Horner, PJ 2022, , World neurosurgery, vol. 166, pp. e460-e468. https://doi.org/10.1016/j.wneu.2022.07.017


Languages

  • English