Joseph Masdeu Download Headshot

Joseph C. Masdeu, MD, PhD

  • Houston Methodist neurologist
  • Director of the Houston Methodist Nantz National Alzheimer Center
  • Graham Family Distinguished Endowed Chair in Neurological Sciences
  • Professor of Neurology, Weill Cornell Medical College
Media Contact: Patti Muck , 832.667.5740

Joseph C. Masdeu, MD, PhD

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Media Contact: Patti Muck , 832.667.5740

Areas of Expertise

  • Alzheimer’s disease
  • Behavioral disorders
  • Gait disorders
  • Memory disorders
  • Neurodegenerative disorders
  • Neuroimaging
  • Traumatic brain injury

Credentials

BOARD CERTIFICATION
American Board of Psychiatry and Neurology, Neurology
Neuroimaging | The United Council for Neurological Subspecialties
MEDICAL SCHOOL
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain | 1969
INTERNSHIP
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
RESIDENCY
Neurology, Mount Sinai Hospital, Chicago, Illinois

Publications

Brain inflammation co-localizes highly with tau in mild cognitive impairment due to early-onset Alzheimer's disease
Appleton, J, Finn, Q, Zanotti-Fregonara, P, Yu, M, Faridar, A, Nakawah, MO, Zarate, C, Carrillo, M, Dickerson, BC, Rabinovici, G, Apostolova, LG, Masdeu, JC & Pascual, B 2024, , Brain. https://doi.org/10.1093/brain/awae234



Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS
Lochner, RH, Arumanayagam, AS, Powell, SZ, Masdeu, JC, Pascual, B & Cykowski, MD 2024, , Journal of Neuropathology and Experimental Neurology, vol. 83, no. 5, pp. 307-317. https://doi.org/10.1093/jnen/nlae027

Research Participants' Perspectives on Precision Diagnostics for Alzheimer's Disease
Smith, HS, Robinson, JO, Levchenko, A, Pereira, S, Pascual, B, Bradbury, K, Arbones, V, Fong, J, Shulman, JM, Mcguire, AL & Masdeu, J 2024, , Journal of Alzheimers Disease, vol. 97, no. 3, pp. 1261-1274. https://doi.org/10.3233/JAD-230609

Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration
Staffaroni, AM, Clark, AL, Taylor, JC, Heuer, HW, Sanderson-Cimino, M, Wise, AB, Dhanam, S, Cobigo, Y, Wolf, A, Manoochehri, M, Forsberg, L, Mester, C, Rankin, KP, Appleby, BS, Bayram, E, Bozoki, A, Clark, D, Darby, RR, Domoto-Reilly, K, Fields, JA, Galasko, D, Geschwind, D, Ghoshal, N, Graff-Radford, N, Grossman, M, Hsiung, GY, Huey, ED, Jones, DT, Lapid, MI, Litvan, I, Masdeu, JC, Massimo, L, Mendez, MF, Miyagawa, T, Pascual, B, Pressman, P, Ramanan, VK, Ramos, EM, Rascovsky, K, Roberson, ED, Tartaglia, MC, Wong, B, Miller, BL, Kornak, J, Kremers, W, Hassenstab, J, Kramer, JH, Boeve, BF, Rosen, HJ & Boxer, AL 2024, , JAMA Network Open, pp. E244266. https://doi.org/10.1001/jamanetworkopen.2024.4266


A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, 54, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

Sex and APOE e4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease
Nemes, S, Logan, PE, Manchella, MK, Mundada, NS, La Joie, R, Polsinelli, AJ, Hammers, DB, Koeppe, RA, Foroud, TM, Nudelman, KN, Eloyan, A, Iaccarino, L, Dorsant-Ardón, V, Taurone, A, Thangarajah, M, Dage, JL, Aisen, P, Grinberg, LT, Jack, CR, Kramer, J, Kukull, WA, Murray, ME, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Touroutoglou, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, SJ, Turner, RS, Wingo, TS, Womack, KB, Wolk, DA, Rabinovici, GD, Carrillo, MC, Dickerson, BC & Apostolova, LG 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S49-S63. https://doi.org/10.1002/alz.13403

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data
Alzheimers Disease Metabolomics Consortium (ADMC) & Alzheimers Disease Neuroimaging Initiative (ADNI) 2023, , EBioMedicine, vol. 97, 104820. https://doi.org/10.1016/j.ebiom.2023.104820

Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study
Dage, JL, Eloyan, A, Thangarajah, M, Hammers, DB, Fagan, AM, Gray, JD, Schindler, SE, Snoddy, C, Nudelman, KNH, Faber, KM, Foroud, T, Aisen, P, Griffin, P, Grinberg, LT, Iaccarino, L, Kirby, K, Kramer, J, Koeppe, R, Kukull, WA, La Joie, R, Mundada, NS, Murray, ME, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, AW, Touroutoglou, A, Vemuri, P, Atri, A, Beckett, LA, Day, GS, Graff-Radford, NR, Duara, R, Honig, LS, Jones, DT, Masdeu, JC, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, SJ, Turner, RS, Wingo, TS, Wolk, DA, Womack, KB, Carrillo, MC, Dickerson, BC, Rabinovici, GD & Apostolova, LG 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S115-S125. https://doi.org/10.1002/alz.13399

The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort
Touroutoglou, A, Katsumi, Y, Brickhouse, M, Zaitsev, A, Eckbo, R, Aisen, P, Beckett, L, Dage, JL, Eloyan, A, Foroud, T, Ghetti, B, Griffin, P, Hammers, D, Jack, CR, Kramer, JH, Iaccarino, L, Joie, RL, Mundada, NS, Koeppe, R, Kukull, WA, Murray, ME, Nudelman, K, Polsinelli, AJ, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, JC, Mendez, MF, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, S, Turner, RS, Wingo, TS, Wolk, DA, Womack, K, Carrillo, MC, Rabinovici, GD, Apostolova, LG & Dickerson, BC 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S74-S88. https://doi.org/10.1002/alz.13466

Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease
Bushnell, J, Hammers, DB, Aisen, P, Dage, JL, Eloyan, A, Foroud, T, Grinberg, LT, Iaccarino, L, Jack, CR, Kirby, K, Kramer, J, Koeppe, R, Kukull, WA, La Joie, R, Mundada, NS, Murray, ME, Nudelman, K, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Touroutoglou, A, Vemuri, P, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, M, Musiek, E, Onyike, CU, Riddle, M, Rogalski, E, Salloway, S, Sha, S, Turner, RS, Wingo, TS, Wolk, DA, Carrillo, MC, Dickerson, BC, Rabinovici, GD, Apostolova, LG & Clark, DG 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S29-S41. https://doi.org/10.1002/alz.13434


White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Early-onset Alzheimer's Disease Study (LEADS)
Eloyan, A, Thangarajah, M, An, N, Borowski, BJ, Reddy, AL, Aisen, P, Dage, JL, Foroud, T, Ghetti, B, Griffin, P, Hammers, D, Iaccarino, L, Jack, CR, Kirby, K, Kramer, J, Koeppe, R, Kukull, WA, La Joie, R, Mundada, NS, Murray, ME, Nudelman, K, Rumbaugh, M, Soleimani-Meigooni, DN, Toga, A, Touroutoglou, A, Atri, A, Day, GS, Duara, R, Graff-Radford, NR, Honig, LS, Jones, DT, Masdeu, J, Mendez, MF, Musiek, E, Onyike, CU, Rogalski, E, Salloway, S, Sha, S, Turner, RS, Wingo, TS, Wolk, DA, Womack, K, Beckett, L, Gao, S, Carrillo, MC, Rabinovici, G, Apostolova, LG, Dickerson, B & Vemuri, P 2023, , Alzheimers and Dementia, vol. 19, no. S9, pp. S89-S97. https://doi.org/10.1002/alz.13402

PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging
Ianni, AM, Eisenberg, DP, Boorman, ED, Constantino, SM, Hegarty, CE, Gregory, MD, Masdeu, JC, Kohn, PD, Behrens, TE & Berman, KF 2023, , Nature Communications, vol. 14, no. 1, 6122, pp. 6122. https://doi.org/10.1038/s41467-023-41897-0

Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration
Asken, BM, Ljubenkov, PA, Staffaroni, AM, Casaletto, KB, Vandevrede, L, Cobigo, Y, Rojas-Rodriguez, JC, Rankin, KP, Kornak, J, Heuer, H, Shigenaga, J, Appleby, BS, Bozoki, AC, Domoto-Reilly, K, Ghoshal, N, Huey, E, Litvan, I, Masdeu, JC, Mendez, MF, Pascual, B, Pressman, P, Tartaglia, MC, Kremers, W, Forsberg, LK, Boeve, BF, Boxer, AL, Rosen, HJ & Kramer, JH 2023, , Journal of Neurology, Neurosurgery and Psychiatry, vol. 94, no. 7, pp. 541-549. https://doi.org/10.1136/jnnp-2022-330866

Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration
ALLFTD Consortium Investigators 2023, , Journal of neurology, neurosurgery, and psychiatry, vol. 94, no. 7, pp. 541-549. https://doi.org/10.1136/jnnp-2022-330866

Regional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression
Alzheimers Disease Neuroimaging Initiative 2023, , Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 78, no. 6, pp. 872-881. https://doi.org/10.1093/gerona/glac209

Languages

  • English
  • Spanish