Joseph C. Masdeu, MD, PhD

  • Houston Methodist neurologist
  • Director of the Houston Methodist Nantz National Alzheimer Center
  • Graham Family Distinguished Endowed Chair in Neurological Sciences
  • Professor of Neurology, Weill Cornell Medical College

Joseph C. Masdeu, MD, PhD

Areas of Expertise

  • Alzheimer’s disease
  • Behavioral disorders
  • Gait disorders
  • Memory disorders
  • Neurodegenerative disorders
  • Neuroimaging
  • Traumatic brain injury

Credentials

BOARD CERTIFICATION
American Board of Psychiatry and Neurology, Neurology
Neuroimaging | The United Council for Neurological Subspecialties
MEDICAL SCHOOL
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain | 1969
INTERNSHIP
Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
RESIDENCY
Neurology, Mount Sinai Hospital, Chicago, Illinois

Publications

État Criblé: High-Resolution MRI and Metabolism
Weil, EL, Finn, Q, Eid, AM, Karmonik, C, Pascual, B, Masdeu, JC & Alzheimer Disease Neuroimaging Initiative 2025, , Neurology, vol. 104, no. 4, pp. e213358. https://doi.org/10.1212/WNL.0000000000213358

Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease
Casaletto, KB, Saloner, R, Kornak, J, Staffaroni, AM, Villeda, S, Paolillo, E, VandeBunte, AM, Cadwallader, CJ, Lario Lago, A, Webb, J, Chen, C, Rascovsky, K, Miyagawa, T, Ramos, EM, Masdeu, JC, Pantelyat, A, Tartaglia, MC, Bozoki, A, Pressman, PS, Rademakers, R, Kremers, W, Darby, R, Younes, K, Pascual, B, Ghoshal, N, Lapid, M, Mackenzie, IRA, Li, J, Hsiung, G-YR, Hall, JN, Yutsis, MV, Litvan, I, Henderson, VW, Sivasankaran, R, Worringer, K, Domoto-Reilly, K, Synder, A, Loureiro, J, Kramer, JH, Heuer, H, Forsberg, LK, Rosen, HJ, Boeve, B, Rojas, JC & Boxer, AL 2025, , Brain Communications, vol. 7, no. 1, fcae432. https://doi.org/10.1093/braincomms/fcae432, https://doi.org/10.1093/braincomms/fcae432

Impact of race/ethnicity and area deprivation index on Alzheimer’s disease and related disorders biomarkers in the POINTER Cohort
Toledo, JB, Pascual, B, Landau, SM, Harrison, TM, Finn, Q, Demesie, YN, Yu, M, Decarli, C, Vemuri, P, Baker, LD, Lovato, L, Snyder, HM, Masdeu, JC & Pavlik, V 2024, , Alzheimers and Dementia, vol. 20, no. Suppl 2. https://doi.org/10.1002/alz.089954


Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration
Vandebergh, M, Ramos, EM, Corriveau-Lecavalier, N, Ramanan, VK, Kornak, J, Mester, C, Kolander, T, Brushaber, DE, Staffaroni, AM, Geschwind, DH, Wolf, AA, Kantarci, K, Gendron, T, Petrucelli, L, Van Den Broeck, M, Wynants, S, Baker, M, Borrego-Écija, S, Appleby, B, Barmada, S, Bozoki, AC, Clark, D, Darby, RR, Dickerson, BC, Domoto-Reilly, K, Fields, JA, Galasko, D, Ghoshal, N, Graff-Radford, NR, Grant, IM, Honig, LS, Hsiung, GYR, Huey, ED, Irwin, DJ, Knopman, DS, Kwan, JY, Léger, GC, Litvan, I, Masdeu, JC, Mendez, MF, Onyike, CU, Pascual, B, Pressman, PS, Ritter, A, Roberson, ED, Snyder, A, Sullivan, AC, Tartaglia, MC, Wint, D, Heuer, HW, Forsberg, LK, Boxer, AL, Rosen, HJ, Boeve, BF & Rademakers, R 2024, , Neurology, vol. 103, no. 8, e209832. https://doi.org/10.1212/WNL.0000000000209832

Brain inflammation co-localizes highly with tau in mild cognitive impairment due to early-onset Alzheimer's disease
Appleton, J, Finn, Q, Zanotti-Fregonara, P, Yu, M, Faridar, A, Nakawah, MO, Zarate, C, Carrillo, MC, Dickerson, BC, Rabinovici, GD, Apostolova, LG, Masdeu, JC & Pascual, B 2025, , Brain, vol. 148, no. 1, pp. 119-132. https://doi.org/10.1093/brain/awae234, https://doi.org/10.1093/brain/awae234

Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study
ALLFTD consortium, Paolillo, EW, Casaletto, KB, Clark, AL, Taylor, JC, Heuer, HW, Wise, AB, Dhanam, S, Sanderson-Cimino, M, Saloner, R, Kramer, JH, Kornak, J, Kremers, W, Forsberg, L, Appleby, B, Bayram, E, Bozoki, A, Brushaber, D, Darby, RR, Day, GS, Dickerson, BC, Domoto-Reilly, K, Elahi, F, Fields, JA, Ghoshal, N, Graff-Radford, N, Hall, MGH, Honig, LS, Huey, ED, Lapid, MI, Litvan, I, Mackenzie, IR, Masdeu, JC, Mendez, MF, Mester, C, Miyagawa, T, Naasan, G, Pascual, B, Pressman, P, Ramos, EM, Rankin, KP, Rexach, J, Rojas, JC, VandeVrede, L, Wong, B, Wszolek, ZK, Boeve, BF, Rosen, HJ, Boxer, AL, Staffaroni, AM & Apostolova, L 2024, , JMIR Aging, vol. 7, e52831, pp. e52831. https://doi.org/10.2196/52831, https://doi.org/10.2196/52831


Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS
Lochner, RH, Arumanayagam, AS, Powell, SZ, Masdeu, JC, Pascual, B & Cykowski, MD 2024, , Journal of Neuropathology and Experimental Neurology, vol. 83, no. 5, pp. 307-317. https://doi.org/10.1093/jnen/nlae027

Research Participants' Perspectives on Precision Diagnostics for Alzheimer's Disease
Smith, HS, Robinson, JO, Levchenko, A, Pereira, S, Pascual, B, Bradbury, K, Arbones, V, Fong, J, Shulman, JM, Mcguire, AL & Masdeu, J 2024, , Journal of Alzheimers Disease, vol. 97, no. 3, pp. 1261-1274. https://doi.org/10.3233/JAD-230609

Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration
Staffaroni, AM, Clark, AL, Taylor, JC, Heuer, HW, Sanderson-Cimino, M, Wise, AB, Dhanam, S, Cobigo, Y, Wolf, A, Manoochehri, M, Forsberg, L, Mester, C, Rankin, KP, Appleby, BS, Bayram, E, Bozoki, A, Clark, D, Darby, RR, Domoto-Reilly, K, Fields, JA, Galasko, D, Geschwind, D, Ghoshal, N, Graff-Radford, N, Grossman, M, Hsiung, GY, Huey, ED, Jones, DT, Lapid, MI, Litvan, I, Masdeu, JC, Massimo, L, Mendez, MF, Miyagawa, T, Pascual, B, Pressman, P, Ramanan, VK, Ramos, EM, Rascovsky, K, Roberson, ED, Tartaglia, MC, Wong, B, Miller, BL, Kornak, J, Kremers, W, Hassenstab, J, Kramer, JH, Boeve, BF, Rosen, HJ & Boxer, AL 2024, , JAMA Network Open, pp. E244266. https://doi.org/10.1001/jamanetworkopen.2024.4266

Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI
the LEADS Consortium 1 for the Alzheimers Disease Neuroimaging Initiative 2025, , Alzheimers and Dementia, vol. 21, no. 1, e14218. https://doi.org/10.1002/alz.14218




Neuroimaging Biomarkers in Alzheimer’s Disease and Related Disorders
Masdeu, JC & Pascual, B 2024, . in Biomarkers in Neuropsychiatry: A Primer. Springer International Publishing, pp. 163-188. https://doi.org/10.1007/978-3-031-43356-6_11


Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
Alzheimers Disease Neuroimaging Initiative 2023, , Communications Medicine, vol. 3, no. 1, 100. https://doi.org/10.1038/s43856-023-00313-w

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, 54, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer's disease
Faridar, A, Eid, AM, Thome, AD, Zhao, W, Beers, DR, Pascual, MB, Nakawah, MO, Roman, GC, Davis, CS, Grundman, M, Masdeu, JC & Appel, SH 2023, , Translational Neurodegeneration, vol. 12, no. 1, pp. 54. https://doi.org/10.1186/s40035-023-00387-5

Languages

  • English
  • Spanish