John Cooke Download Headshot

John P. Cooke, MD, PhD

  • Chair, Houston Methodist Research Institute Department of Cardiovascular Sciences
  • Director, Houston Methodist Center for Cardiovascular Regeneration
  • Professor of Cardiovascular Sciences, Houston Methodist Research Institute
  • Joseph C. “Rusty” Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

John P. Cooke, MD, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Aging research
  • Cardiovascular Regeneration
  • Endothelium
  • Regenerative medicine
  • Stem cells
  • Studies reversing aging in progeria
  • Telomeres
  • Vascular disease

Credentials

Clinical Fellowship, Mayo Graduate School of Medicine, Rochester, MN
Residency, Mayo Graduate School of Medicine, Rochester, MN
Internship, Mayo Graduate School of Medicine, Rochester, MN
MD, Wayne State Univ. School of Medicine
PhD, Mayo Graduate School of Medicine, Rochester, NY
Research Fellowship, Mayo Graduate School of Medicine, Rochester, NY

Publications

Application of validated size-exclusion chromatography method for physicochemical characterization of topical gel formulation of deferoxamine conjugated with PEGylated carbon nanoparticles
Khan, AA, Mohamed, EM, Kashif Iqubal, M, Tour, JM, McHugh, EA, Chang, DF, Cooke, JP, Rahman, Z & Kent, TA 2024, , International Journal of Pharmaceutics, vol. 666, 124834. https://doi.org/10.1016/j.ijpharm.2024.124834

EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation
Bai, Y, Chen, L, Guo, F, Zhang, J, Hu, J, Tao, X, Lu, Q, Li, W, Chen, X, Gong, T, Qiu, N, Jin, Y, Yang, L, Lei, Y, Ruan, C, Jing, Q, Cooke, JP, Wang, S, Zou, Y & Ge, J 2024, , Signal Transduction and Targeted Therapy, vol. 9, no. 1, 326, pp. 326. https://doi.org/10.1038/s41392-024-02019-4

1034 Development of HLA class I expressing humanized patient-derived xenograft (hu-PDX) mouse models for the study of mRNA-based cancer vaccines in triple-negative breast cancer
Chervo, MF, Qian, W, Ortega Martinez, KA, Zhou, J, Shroff, R, Mancino, C, Rojas, LG, Taraballi, F, Cooke, JP, Gollihar, JD & Chang, JC 2024, , J Immunother Cancer, vol. 12, no. Suppl 2, pp. A1155. https://doi.org/10.1136/jitc-2024-SITC2024.1034

ß-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model
Nelson, AL, Mancino, C, Gao, X, Choe, JA, Chubb, L, Williams, K, Czachor, M, Marcucio, R, Taraballi, F, Cooke, JP, Huard, J, Bahney, C & Ehrhart, N 2024, , Bioactive Materials, vol. 39, pp. 273-286. https://doi.org/10.1016/j.bioactmat.2024.05.020

Established and Emerging Nucleic Acid Therapies for Familial Hypercholesterolemia
Damase, TR, Sukhovershin, R, Godin, B, Nasir, K & Cooke, JP 2024, , Circulation, vol. 150, no. 9, pp. 724-735. https://doi.org/10.1161/CIRCULATIONAHA.123.067957

Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: the CAST-HF trial
Holfeld, J, Nägele, F, Pölzl, L, Engler, C, Graber, M, Hirsch, J, Schmidt, S, Mayr, A, Troger, F, Pamminger, M, Theurl, M, Schreinlechner, M, Sappler, N, Ruttmann-Ulmer, E, Schaden, W, Cooke, JP, Ulmer, H, Bauer, A, Gollmann-Tepeköylü, C & Grimm, M 2024, , European heart journal, vol. 45, no. 29, pp. 2634-2643. https://doi.org/10.1093/eurheartj/ehae341

A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Banerjee, P, Chau, K, Kotla, S, Davis, EL, Turcios, EB, Li, S, Pengzhi, Z, Wang, G, Kolluru, GK, Jain, A, Cooke, JP, Abe, J & Le, N-T 2024, , Current Atherosclerosis Reports, vol. 26, no. 9, pp. 463-483. https://doi.org/10.1007/s11883-024-01223-5

Age-related disease: Effective intervention
Fossel, M & Cooke, JP 2024, . in Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases. Elsevier, pp. 219-232. https://doi.org/10.1016/B978-0-443-15500-0.00013-X

Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation
Cooke, JP, Youker, KA & Lai, L 2024, , Methodist DeBakey cardiovascular journal, vol. 20, no. 4, pp. 31-41. https://doi.org/10.14797/mdcvj.1400


Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nayfeh, M, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2023, , European Heart Journal Cardiovascular Imaging, vol. 24, no. 11, pp. 1544-1554. https://doi.org/10.1093/ehjci/jead118

Disrupted stiffness ratio alters nuclear mechanosensing
Walther, BK, Sears, AP, Mojiri, A, Avazmohammadi, R, Gu, J, Chumakova, OV, Rajeeva Pandian, NK, Dominic, A, Martiel, JL, Yazdani, SK, Cooke, JP, Ohayon, J & Pettigrew, RI 2023, , Matter, vol. 6, no. 10, pp. 3608-3630. https://doi.org/10.1016/j.matt.2023.08.010


A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension
Zhuang, T, Lei, Y, Chang, JJ, Zhou, YP, Li, Y, Li, YX, Yang, YF, Chen, MH, Meng, T, Fu, SM, Huang, LH, Cheang, WS, Cooke, JP, Dong, ZH, Bai, YN & Ruan, CC 2023, , European heart journal, vol. 44, no. 29, pp. 2730-2742. https://doi.org/10.1093/eurheartj/ehad377

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, J-I, Imanishi, M, Li, S, Zhang, A, Ko, KA, Samanthapudi, VSK, Lee, L-L, Bojorges, AP, Gi, YJ, Hobbs, BP, Deswal, A, Herrmann, J, Lin, SH, Chini, EN, Shen, YH, Schadler, KL, Nguyen, T-H-M, Gupte, AA, Reyes-Gibby, C, Yeung, S-CJ, Abe, RJ, Olmsted-Davis, EA, Krishnan, S, Dantzer, R, Palaskas, NL, Cooke, JP, Pownall, HJ, Yoshimoto, M, Fujiwara, K, Hamilton, DJ, Burks, JK, Wang, G, Le, N-T & Kotla, S 2023, , Circulation Research, vol. 133, no. 1, pp. 25-44. https://doi.org/10.1161/CIRCRESAHA.122.322017

Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Ahmed, AI, Al Rifai, M, Alahdab, F, Saad, JM, Han, Y, Alfawara, MS, Nayfeh, M, Malahfji, M, Nabi, F, Mahmarian, JJ, Cooke, JP, Zoghbi, WA & Al-Mallah, MH 2023, , European Heart Journal Cardiovascular Imaging, vol. 24, no. 11, pp. 1544-1554. https://doi.org/10.1093/ehjci/jead118

Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Lv, J, Meng, S, Gu, Q, Zheng, R, Gao, X, Kim, JD, Chen, M, Xia, B, Zuo, Y, Zhu, S, Zhao, D, Li, Y, Wang, G, Wang, X, Meng, Q, Cao, Q, Cooke, JP, Fang, L, Chen, K & Zhang, L 2023, , Nature Communications, vol. 14, no. 1, 2842, pp. 2842. https://doi.org/10.1038/s41467-023-38708-x

Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients
Selamet Tierney, ES, Palaniappan, L, Leonard, M, Long, J, Myers, J, Dávila, T, Lui, MC, Kogan, F, Olson, I, Punn, R, Desai, M, Schneider, LM, Wang, CH, Cooke, JP & Bernstein, D 2023, , American Heart Journal, vol. 259, pp. 68-78. https://doi.org/10.1016/j.ahj.2023.02.006

Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Lv, J, Meng, S, Gu, Q, Zheng, R, Gao, X, Kim, JD, Chen, M, Xia, B, Zuo, Y, Zhu, S, Zhao, D, Li, Y, Wang, G, Wang, X, Meng, Q, Cao, Q, Cooke, JP, Fang, L, Chen, K & Zhang, L 2023, , Nature Communications, vol. 14, no. 1, 2390, pp. 2390. https://doi.org/10.1038/s41467-023-38002-w

A relay velocity model infers cell-dependent RNA velocity
Li, S, Zhang, P, Chen, W, Ye, L, Brannan, KW, Le, NT, Abe, JI, Cooke, JP & Wang, G 2023, , Nature Biotechnology, vol. 42, no. 1, pp. 99-108. https://doi.org/10.1038/s41587-023-01728-5

Languages

  • English