Jenny Chang Download Headshot

Jenny Chang, MD

  • Houston Methodist breast medical oncologist
  • Director, Houston Methodist Cancer Center
  • Professor of Medicine, Weill Cornell Medical College
  • Emily Herrmann Chair in Cancer Research, Houston Methodist Hospital 
Media Contact: Amy Rose , 412.613.1428

Jenny Chang, MD

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Media Contact: Amy Rose , 412.613.1428

Areas of Expertise

  • Breast cancer
  • Cancer clinical trials
  • Cancer stem cell resistance
  • Immunotherapies and other targeted biotherapeutics
  • Metastatic breast cancer
  • Triple negative breast cancer

Credentials

BOARD CERTIFICATION
Oncology
MEDICAL SCHOOL
Cambridge University School of Clinical Medicine-Cambridge, UK | 1989
RESIDENCY
Cambridge University - Cambridge, UK
FELLOWSHIP
University of London - Medical Oncology - London, UK
Institute of Cancer Research - London, UK

Publications

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors
Ridnour, LA, Cheng, RYS, Kedei, N, Somasundaram, V, Bhattacharyya, DD, Basudhar, D, Wink, AL, Walke, AJ, Kim, C, Heinz, WF, Edmondson, EF, Butcher, DO, Warner, AC, Dorsey, TH, Pore, M, Kinders, RJ, Lipkowitz, S, Bryant, RJ, Rittscher, J, Wong, STC, Hewitt, SM, Chang, JC, Shalaby, A, Callagy, GM, Glynn, SA, Ambs, S, Anderson, SK, McVicar, DW, Lockett, SJ & Wink, DA 2024, , JCI insight, vol. 9, no. 12, e165356. https://doi.org/10.1172/jci.insight.165356

Ketogenic diet induces p53-dependent cellular senescence in multiple organs
Wei, SJ, Schell, JR, Chocron, ES, Varmazyad, M, Xu, G, Chen, WH, Martinez, GM, Dong, FF, Sreenivas, P, Trevino, R, Jiang, H, Du, Y, Saliba, A, Qian, W, Lorenzana, B, Nazarullah, A, Chang, J, Sharma, K, Munkácsy, E, Horikoshi, N & Gius, D 2024, , Science Advances, vol. 10, no. 20, eado1463. https://doi.org/10.1126/sciadv.ado1463

Correlation of HER2 Protein Level With mRNA Level Quantified by RNAscope in Breast Cancer
Li, X, Lee, JH, Gao, Y, Zhang, J, Bates, KM, Rimm, DL, Zhang, H, Smith, GH, Lawson, D, Meisel, J, Chang, J & Huo, L 2024, , Modern Pathology, vol. 37, no. 2, 100408. https://doi.org/10.1016/j.modpat.2023.100408

The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer
O’Neill, CE, Sun, K, Sundararaman, S, Chang, JC & Glynn, SA 2024, , Frontiers in Physiology, vol. 15, 1358850. https://doi.org/10.3389/fphys.2024.1358850

Neighborhood Walkability Is Associated With Lower Burden of Cardiovascular Risk Factors Among Cancer Patients
Nwana, N, Makram, OM, Nicolas, JC, Pan, A, Gullapelli, R, Parekh, T, Javed, Z, Titus, A, Al-Kindi, S, Guan, J, Sun, K, Jones, SL, Maddock, JE, Chang, J & Nasir, K 2024, , JACC: CardioOncology, vol. 6, no. 3, pp. 421-435. https://doi.org/10.1016/j.jaccao.2024.03.009

A Deep Learning Decision Support Tool to Improve Risk Stratification and Reduce Unnecessary Biopsies in BI-RADS 4 Mammograms
Ezeana, CF, He, T, Patel, TA, Kaklamani, V, Elmi, M, Brigmon, E, Otto, PM, Kist, KA, Speck, H, Wang, L, Ensor, J, Shih, YCT, Kim, B, Pan, IW, Cohen, AL, Kelley, K, Spak, D, Yang, WT, Chang, JC & Wong, STC 2023, , Radiology: Artificial Intelligence, vol. 5, no. 6, e220259, pp. e220259. https://doi.org/10.1148/ryai.220259

Targeting Nitric Oxide: Say NO to Metastasis
Reddy, TP, Glynn, SA, Billiar, TR, Wink, DA & Chang, JC 2023, , Clinical Cancer Research, vol. 29, no. 10, pp. 1855-1868. https://doi.org/10.1158/1078-0432.CCR-22-2791

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
Cheng, RYS, Ridnour, LA, Wink, AL, Gonzalez, AL, Femino, EL, Rittscher, H, Somasundaram, V, Heinz, WF, Coutinho, L, Rangel, MC, Edmondson, EF, Butcher, D, Kinders, RJ, Li, X, Wong, STC, McVicar, DW, Anderson, SK, Pore, M, Hewitt, SM, Billiar, TR, Glynn, SA, Chang, JC, Lockett, SJ, Ambs, S & Wink, DA 2023, , Cell Death and Disease, vol. 14, no. 5, 319, pp. 319. https://doi.org/10.1038/s41419-023-05834-9

A Phase II Single-arm Study of Palbociclib in Patients With HER2-positive Breast Cancer With Brain Metastases and Analysis of ctDNA in Patients With Active Brain Metastases
Shah, AN, Santa-Maria, CA, Mukhija, D, Shah, N, Kang, AK, Kumthekar, P, Burdett, K, Chandra, S, Chang, J, Tsarwhas, D, Woodman, J, Jovanovic, B, Gerratana, L, Gradishar, W & Cristofanilli, M 2023, , Clinical Breast Cancer, vol. 23, no. 3, pp. 324-329. https://doi.org/10.1016/j.clbc.2022.12.006

A Phase 2 Study of In Situ Oncolytic Virus Therapy and Stereotactic Body Radiation Therapy Followed by Pembrolizumab in Metastatic Non-Small Cell Lung Cancer
Guan, J, Sun, K, Guerrero, CA, Zheng, J, Xu, Y, Mathur, S, Teh, BS, Farach, A, Zhang, J, Butler, E, Pan, PY, Zsigmond, E, Mei, Z, Mejia, J, Chen, SH, Chang, JC & Bernicker, EH 2023, , International Journal of Radiation Oncology Biology Physics, vol. 118, no. 5, pp. 1531-1540. https://doi.org/10.1016/j.ijrobp.2023.08.044



Understanding the anti-metastatic activity of estrogen receptor ß in inflammatory breast cancer
Thomas, C, Karagounis, IV, Tastsoglou, S, Nagandla, H, Ueno, N, Khrishnamurthy, S, Chang, JC, Maity, A & Chatzigeorgiou, A 2023, .

NOS inhibition sensitizes metaplastic breast cancer to alpelisib and taxane chemotherapy by reversing cJUN-mediated epithelial-to-mesenchymal transition.
Reddy, TP, Puri, A, Guzman-Rojas, L, Thomas, C, Qian, W, Zhou, J, Zhao, H, Thaiparambil, J, Rosato, RR, Chervo, M, Giese, N, Yam, C, Moulder, SL, Piwnica-Worms, H, Meric-Bernstam, F, Mahboubi, B, Oo, A, Kim, B, Ayerbe, C & Chang, JC 2023, , Nature Communications.

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density
Somasundaram, V, Ridnour, LA, Cheng, RYS, Walke, AJ, Kedei, N, Bhattacharyya, DD, Wink, AL, Edmondson, EF, Butcher, D, Warner, AC, Dorsey, TH, Scheiblin, DA, Heinz, W, Bryant, RJ, Kinders, RJ, Lipkowitz, S, Wong, STC, Pore, M, Hewitt, SM, McVicar, DW, Anderson, SK, Chang, J, Glynn, SA, Ambs, S, Lockett, SJ & Wink, DA 2022, , Redox Biology, vol. 58, 102529, pp. 102529. https://doi.org/10.1016/j.redox.2022.102529, https://doi.org/10.1016/j.redox.2022.102529

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density
Somasundaram, V, Ridnour, LA, Cheng, RYS, Walke, AJ, Kedei, N, Bhattacharyya, DD, Wink, AL, Edmondson, EF, Butcher, D, Warner, AC, Dorsey, TH, Scheiblin, DA, Heinz, W, Bryant, RJ, Kinders, RJ, Lipkowitz, S, Wong, STC, Pore, M, Hewitt, SM, McVicar, DW, Anderson, SK, Chang, J, Glynn, SA, Ambs, S, Lockett, SJ & Wink, DA 2022, , Redox Biology, vol. 58, 102529. https://doi.org/10.1016/j.redox.2022.102529

Adjuvant trastuzumab emtansine in HER2-positive breast cancer patients with HER2-negative residual invasive disease in KATHERINE
Loibl, S, Huang, CS, Mano, MS, Mamounas, EP, Geyer, CE, Untch, M, Thery, JC, Schwaner, I, Limentani, S, Loman, N, Lübbe, K, Chang, JC, Hatschek, T, Tesarowski, D, Song, C, Lysbet de Haas, S, Boulet, T, Lambertini, C & Wolmark, N 2022, , npj Breast Cancer, vol. 8, no. 1, 106. https://doi.org/10.1038/s41523-022-00477-z

A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
Mathur, SK, Sun, K, Chang, JC, Niravath, PA, Darcourt, J, Patel, T & Teh, BS 2022, , Clinical Cancer Research, vol. 28, no. 20, pp. 4392-4401. https://doi.org/10.1158/1078-0432.CCR-22-0622

A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
Sun, K, Xu, Y, Zhang, L, Niravath, P, Darcourt, J, Patel, T, Teh, BS, Farach, AM, Guerrero, C, Mathur, S, Sultenfuss, MA, Gupta, N, Schwartz, MR, Haley, SL, Nair, S, Li, X, Nguyen, TTA, Butner, JD, Ensor, J, Mejia, JA, Mei, Z, Butler, EB, Chen, SH, Bernicker, EH & Chang, JC 2022, , Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 28, no. 20, pp. 4392-4401. https://doi.org/10.1158/1078-0432.CCR-22-0622, https://doi.org/10.1158/1078-0432.CCR-22-0622

A comparative efficacy study of diagnostic digital breast tomosynthesis and digital mammography in BI-RADS 4 breast cancer diagnosis
Ezeana, CF, Puppala, M, Wang, L, Chang, JC & Wong, STC 2022, , European Journal of Radiology, vol. 153, 110361, pp. 110361. https://doi.org/10.1016/j.ejrad.2022.110361

Languages

  • English