Jenny Chang, MD

  • Houston Methodist breast medical oncologist
  • Director, Houston Methodist Cancer Center
  • Professor of Medicine, Weill Cornell Medical College
  • Emily Herrmann Chair in Cancer Research, Houston Methodist Hospital 

Jenny Chang, MD

Areas of Expertise

  • Breast cancer
  • Cancer clinical trials
  • Cancer stem cell resistance
  • Immunotherapies and other targeted biotherapeutics
  • Metastatic breast cancer
  • Triple negative breast cancer

Credentials

BOARD CERTIFICATION
Oncology
MEDICAL SCHOOL
Cambridge University School of Clinical Medicine-Cambridge, UK | 1989
RESIDENCY
Cambridge University - Cambridge, UK
FELLOWSHIP
University of London - Medical Oncology - London, UK
Institute of Cancer Research - London, UK

Publications

HER2-positive breast cancer in patients with BRCA1/2 pathogenic variants: Case series and literature review
Munnangi, P, Niravath, PA, Chang, JC & Sun, K 2025, , Current Problems in Cancer: Case Reports, vol. 17, 100335. https://doi.org/10.1016/j.cpccr.2024.100335

1034 Development of HLA class I expressing humanized patient-derived xenograft (hu-PDX) mouse models for the study of mRNA-based cancer vaccines in triple-negative breast cancer
Chervo, MF, Qian, W, Ortega Martinez, KA, Zhou, J, Shroff, R, Mancino, C, Rojas, LG, Taraballi, F, Cooke, JP, Gollihar, JD & Chang, JC 2024, , J Immunother Cancer, vol. 12, no. Suppl 2, pp. A1155. https://doi.org/10.1136/jitc-2024-SITC2024.1034

Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer
Ridnour, LA, Heinz, WF, Cheng, RYS, Wink, AL, Kedei, N, Pore, M, Imtiaz, F, Femino, EL, Gonzalez, AL, Coutinho, LL, Moffat, RL, Butcher, D, Edmondson, EF, Li, X, Rangel, MC, Kinders, RJ, Rittscher, J, Lipkowitz, S, Wong, STC, Anderson, SK, McVicar, DW, Glynn, SA, Billiar, TR, Chang, JC, Hewitt, SM, Ambs, S, Lockett, SJ & Wink, DA 2024, , Cancer research communications, vol. 4, no. 10, pp. 2766-2782. https://doi.org/10.1158/2767-9764.CRC-24-0235

Use of combined chemotherapy and immunotherapy improves pulmonary arterial hypertension
Reddy, TP, Barrios, R, Bernicker, EH, Qian, W, Chang, JC & Safdar, Z 2024, , Pulmonary Circulation, vol. 14, no. 3, e12426. https://doi.org/10.1002/pul2.12426

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors
Ridnour, LA, Cheng, RYS, Kedei, N, Somasundaram, V, Bhattacharyya, DD, Basudhar, D, Wink, AL, Walke, AJ, Kim, C, Heinz, WF, Edmondson, EF, Butcher, DO, Warner, AC, Dorsey, TH, Pore, M, Kinders, RJ, Lipkowitz, S, Bryant, RJ, Rittscher, J, Wong, STC, Hewitt, SM, Chang, JC, Shalaby, A, Callagy, GM, Glynn, SA, Ambs, S, Anderson, SK, McVicar, DW, Lockett, SJ & Wink, DA 2024, , JCI insight, vol. 9, no. 12, e165356. https://doi.org/10.1172/jci.insight.165356

Ketogenic diet induces p53-dependent cellular senescence in multiple organs
Wei, SJ, Schell, JR, Chocron, ES, Varmazyad, M, Xu, G, Chen, WH, Martinez, GM, Dong, FF, Sreenivas, P, Trevino, R, Jiang, H, Du, Y, Saliba, A, Qian, W, Lorenzana, B, Nazarullah, A, Chang, J, Sharma, K, Munkácsy, E, Horikoshi, N & Gius, D 2024, , Science Advances, vol. 10, no. 20, eado1463. https://doi.org/10.1126/sciadv.ado1463

An on-line deep learning decision support tool, iBRISK, aimed at improving breast cancer risk estimation and reducing unnecessary biopsies for BI-RADS 4 patients
Wong, ST, Ezeana, CF, Yu, X, Cheng He, T, Patel, T, Kaklamani, VG & Chang, JC 2024, . in Proceedings: San Antonio Breast Cancer Symposium 2023. vol. 84, AACR Annual Meeting, San Diego, United States, 4/5/24. https://doi.org/10.1158/1538-7445.SABCS23-PO2-28-06

Correlation of HER2 Protein Level With mRNA Level Quantified by RNAscope in Breast Cancer
Li, X, Lee, JH, Gao, Y, Zhang, J, Bates, KM, Rimm, DL, Zhang, H, Smith, GH, Lawson, D, Meisel, J, Chang, J & Huo, L 2024, , Modern Pathology, vol. 37, no. 2, 100408. https://doi.org/10.1016/j.modpat.2023.100408

The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer
O’Neill, CE, Sun, K, Sundararaman, S, Chang, JC & Glynn, SA 2024, , Frontiers in Physiology, vol. 15, 1358850. https://doi.org/10.3389/fphys.2024.1358850

Neighborhood Walkability Is Associated With Lower Burden of Cardiovascular Risk Factors Among Cancer Patients
Nwana, N, Makram, OM, Nicolas, JC, Pan, A, Gullapelli, R, Parekh, T, Javed, Z, Titus, A, Al-Kindi, S, Guan, J, Sun, K, Jones, SL, Maddock, JE, Chang, J & Nasir, K 2024, , JACC: CardioOncology, vol. 6, no. 3, pp. 421-435. https://doi.org/10.1016/j.jaccao.2024.03.009


Frozen Large-scale Pretrained Vision-Language Models are the Effective Foundational Backbone for Multimodal Breast Cancer Prediction
Vo, HQ, Wang, L, Wong, K, Ezeana, CF, Yu, X, Yang, W, Chang, JC, Nguyen, HV & Wong, ST 2024, , IEEE Journal of Biomedical and Health Informatics, pp. 1-14. https://doi.org/10.1109/JBHI.2024.3507638

A Deep Learning Decision Support Tool to Improve Risk Stratification and Reduce Unnecessary Biopsies in BI-RADS 4 Mammograms
Ezeana, CF, He, T, Patel, TA, Kaklamani, V, Elmi, M, Brigmon, E, Otto, PM, Kist, KA, Speck, H, Wang, L, Ensor, J, Shih, YCT, Kim, B, Pan, IW, Cohen, AL, Kelley, K, Spak, D, Yang, WT, Chang, JC & Wong, STC 2023, , Radiology: Artificial Intelligence, vol. 5, no. 6, e220259, pp. e220259. https://doi.org/10.1148/ryai.220259

Targeting Nitric Oxide: Say NO to Metastasis
Reddy, TP, Glynn, SA, Billiar, TR, Wink, DA & Chang, JC 2023, , Clinical Cancer Research, vol. 29, no. 10, pp. 1855-1868. https://doi.org/10.1158/1078-0432.CCR-22-2791

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome
Cheng, RYS, Ridnour, LA, Wink, AL, Gonzalez, AL, Femino, EL, Rittscher, H, Somasundaram, V, Heinz, WF, Coutinho, L, Rangel, MC, Edmondson, EF, Butcher, D, Kinders, RJ, Li, X, Wong, STC, McVicar, DW, Anderson, SK, Pore, M, Hewitt, SM, Billiar, TR, Glynn, SA, Chang, JC, Lockett, SJ, Ambs, S & Wink, DA 2023, , Cell Death and Disease, vol. 14, no. 5, 319, pp. 319. https://doi.org/10.1038/s41419-023-05834-9

A Phase II Single-arm Study of Palbociclib in Patients With HER2-positive Breast Cancer With Brain Metastases and Analysis of ctDNA in Patients With Active Brain Metastases
Shah, AN, Santa-Maria, CA, Mukhija, D, Shah, N, Kang, AK, Kumthekar, P, Burdett, K, Chandra, S, Chang, J, Tsarwhas, D, Woodman, J, Jovanovic, B, Gerratana, L, Gradishar, W & Cristofanilli, M 2023, , Clinical Breast Cancer, vol. 23, no. 3, pp. 324-329. https://doi.org/10.1016/j.clbc.2022.12.006

A Phase 2 Study of In Situ Oncolytic Virus Therapy and Stereotactic Body Radiation Therapy Followed by Pembrolizumab in Metastatic Non-Small Cell Lung Cancer
Guan, J, Sun, K, Guerrero, CA, Zheng, J, Xu, Y, Mathur, S, Teh, BS, Farach, A, Zhang, J, Butler, E, Pan, PY, Zsigmond, E, Mei, Z, Mejia, J, Chen, SH, Chang, JC & Bernicker, EH 2023, , International Journal of Radiation Oncology Biology Physics, vol. 118, no. 5, pp. 1531-1540. https://doi.org/10.1016/j.ijrobp.2023.08.044



Understanding the anti-metastatic activity of estrogen receptor ß in inflammatory breast cancer
Thomas, C, Karagounis, IV, Tastsoglou, S, Nagandla, H, Ueno, N, Khrishnamurthy, S, Chang, JC, Maity, A & Chatzigeorgiou, A 2023, .

Languages

  • English