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Henry J. Pownall, PhD

  • Medical biochemist, Houston Methodist Research Institute
  • Professor of Biochemistry in Medicine, Houston Methodist Research Institute
  • Atherosclerosis & lipoprotein research director at Houston Methodist Research Institute
  • Professor of Bioenergetics, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

Henry J. Pownall, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Atherogenesis
  • Cardiovascular sciences
  • Cholesterol transport
  • Energy metabolism / human lipid metabolism
  • Fluorescence
  • HDL structure, properties and function
  • High Density Lipoprotein (HDL) therapeutics
  • Molecular ethics
  • Obesity-linked diabetes
  • Physical chemistry

Credentials

Postdoctoral Fellowship, University of Houston
Postdoctoral Fellowship, Baylor College of Medicine
PhD, Northeastern University
MS, Wilkes College, Wilkes-Barre, PA

Publications

HDL-Free Cholesterol Influx into Macrophages and Transfer to LDL Correlate with HDL-Free Cholesterol Content
Yelamanchili, D, Gillard, BK, Gotto, AM, Achirica, MC, Nasir, K, Remaley, AT, Rosales, C & Pownall, HJ 2025, , Journal of lipid research, pp. 100707. https://doi.org/10.1016/j.jlr.2024.100707

Long-term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes
Ashby-Thompson, M, Heshka, S, Anderson, A, Pownall, H, Laferrère, B, Balasubramanyam, A, Heymsfield, SB, Wadden, TA & Gallagher, D 2024, , Obesity, vol. 32, no. 6, pp. 1093-1101. https://doi.org/10.1002/oby.24025

The pathophysiology of excess plasma-free cholesterol
Gillard, BK, Rosales, C, Gotto, AM & Pownall, HJ 2023, , Current opinion in lipidology, vol. 34, no. 6, PMID: 37732779, pp. 278-286. https://doi.org/10.1097/MOL.0000000000000899, https://doi.org/10.1097/MOL.0000000000000899

The pathophysiology of excess plasma-free cholesterol
Gillard, BK, Rosales, C, Gotto, AM & Pownall, HJ 2023, , Current opinion in lipidology, vol. 34, no. 6, pp. 278-286. https://doi.org/10.1097/MOL.0000000000000899

Serum Opacity Factor Normalizes Erythrocyte Morphology in Scarb1-/- Mice in an HDL-Free Cholesterol-Dependent Way.
Wang, Z, Yelamanchili, D, Liu, J, Gotto, AM, Rosales, C, Gillard, BK & Pownall, HJ 2023, , Journal of lipid research, vol. 64, no. 11, 100456, pp. 100456. https://doi.org/10.1016/j.jlr.2023.100456, https://doi.org/10.1016/J.JLR.2023.100456

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, J-I, Imanishi, M, Li, S, Zhang, A, Ko, KA, Samanthapudi, VSK, Lee, L-L, Bojorges, AP, Gi, YJ, Hobbs, BP, Deswal, A, Herrmann, J, Lin, SH, Chini, EN, Shen, YH, Schadler, KL, Nguyen, T-H-M, Gupte, AA, Reyes-Gibby, C, Yeung, S-CJ, Abe, RJ, Olmsted-Davis, EA, Krishnan, S, Dantzer, R, Palaskas, NL, Cooke, JP, Pownall, HJ, Yoshimoto, M, Fujiwara, K, Hamilton, DJ, Burks, JK, Wang, G, Le, N-T & Kotla, S 2023, , Circulation Research, vol. 133, no. 1, pp. 25-44. https://doi.org/10.1161/CIRCRESAHA.122.322017

Normalization of Erythrocyte Morphology in Scarb1-/- Mice by Bacterial Serum Opacity Factor is HDL-Free Cholesterol Dependent
Rosales, C, Wang, Z, Yelamanchili, D, Gotto, A, Gillard, BK & Pownall, HJ 2023, , ASBMB Deuel Conference on Lipids, Dana Point, CA, 3/7/23 - 3/10/23.

Serum opacity factor rescues fertility among female Scarb1-/- mice by reducing HDL-free cholesterol bioavailability
Rosales, C, Yelamanchili, D, Gillard, BK, Liu, J, Gotto, AM & Pownall, HJ 2023, , Journal of lipid research, vol. 64, no. 2, 100327, pp. 100327. https://doi.org/10.1016/j.jlr.2022.100327

The pathophysiology of excess plasma-free cholesterol.
Gillard, BK, Rosales, C, Gotto, A & Pownall, HJ 2023, , Current opinion in lipidology, vol. 34, PMID: 37732779, pp. 278-286.

Serum Opacity Factor Normalizes Erythrocyte Morphology in Scarb1-/- Mice in an HDL-Free Cholesterol-Dependent Way.
Wang, Z, Yelamanchili, D, Liu, J, Gotto, A, Rosales, C, Gillard, BK & Pownall, HJ 2023, , Journal of lipid research.

Serum opacity factor normalizes erythrocyte morphology in Scarb1-/- mice in an HDL-free cholesterol-dependent way
Wang, Z, Yelamanchili, D, Liu, J, Gotto, AM, Rosales, C, Gillard, BK & Pownall, HJ 2023, , Journal of lipid research, vol. 64, no. 11, 100456. https://doi.org/10.1016/J.JLR.2023.100456

Serum Opacity Factor Rescues Fertility among Female Scarb1-/- Mice by Reducing HDL-Free Cholesterol Bioavailability
Rosales, C, Yelamanchili, D, Gillard, BK, Liu, J, Gotto, A & Pownall, HJ 2022, , Journal of lipid research, vol. 64, no. 2, PMID: 36596339.

The Role of Apolipoprotein A1 in Cholesterol Transport
Brenner, D, Chandra, M, Abe, R, Yelamanchili, D, Gillard, BK, Rosales, C & Pownall, HJ 2022, , 5th Annual Summer Science Symposium, Houston, United States, 8/4/22 - 8/5/22.

Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr-/- Mice
Peng, X, Lian, Z, Perrard, XYD, Xiao, Y, Ni, J, O’brien, V, Dong, H, Pownall, HJ, Ballantyne, CM & Wu, H 2022, , Cells, vol. 11, no. 11, 1795. https://doi.org/10.3390/cells11111795

Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr -/- Mice.
Peng, X, Lian, Z, Perrard, X-YD, Xiao, Y, Ni, J, OBrien, V, Dong, H, Pownall, HJ, Ballantyne, CM & Wu, H 2022, , Cells, vol. 11, no. 11, 1795. https://doi.org/10.3390/cells11111795

Excess HDL Free Cholesterol Bioavailability Drives Free Cholesterol Accretion into Macrophages and Erythrocytes in SCRAB1-/- mice
Gillard, BK, Wang, Z, Liu, J, Yelamanchili, D, Gotto, A, Rosales, C & Pownall, HJ 2022, , AHA Vascular Discovery: From Genes to Medicine 2022 Scientific Sessions, Seattle, United States, 5/12/22 - 5/14/22.

Serum Opacity Factor Normalizes Dysfunctionnal High Density Lipoproteins in SRBI-/- Female Mice and Rescues Fertility.
Yelamanchili, D, Gillard, BK, Pownall, HJ, Gotto, A & Rosales, C 2022, , AHA Vascular Discovery: From Genes to Medicine 2022 Scientific Sessions, Seattle, United States, 5/12/22 - 5/14/22.

Weight Change During the Postintervention Follow-up of Look AHEAD
Look AHEAD Research Group 2022, , Diabetes care, vol. 45, no. 6, pp. 1306-1314. https://doi.org/10.2337/dc21-1990

Excess HDL Free Cholesterol Bioavailability Drives Free Cholesterol Accretion into Macrophages and Erythrocytes in SCRAB1-/- mice.
Gillard, BK, Wang, Z, Liu, J, Yelamanchili, D, Gotto, A, Rosales, C & Pownall, HJ 2022, , ASBMB Deuel Conference on Lipids, Monterey, United States, 3/1/22 - 3/4/22.


Languages

  • English