Alessandro Grattoni Download Headshot

Alessandro Grattoni, PhD

  • Chair, Houston Methodist Research Institute Department of Nanomedicine 
  • Professor of Nanomedicine, Houston Methodist Research Institute
Media Contact: Lisa Merkl , 832.667.5916

Alessandro Grattoni, PhD

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Media Contact: Lisa Merkl , 832.667.5916

Areas of Expertise

  • Drug delivery
  • Implantable devices
  • Nanofluidics
  • Nanomedicine
  • Silicon technologies
  • Space medicine

Credentials

MSc, Politecnico di Torino
PhD, Politecnico di Torino
Postdoctoral Fellowship, University of Texas Health Science Center at Houston

Publications

The effect of the foreign body response on drug elution from subdermal delivery systems
Capuani, S, Hernandez, N, Campa-Carranza, JN, Di Trani, N, Yoshikawa, T, Farina, M, Joubert, AL, Caffey, CA, Simeone, A, Cho, SW, Stayton, PS, Chua, CYX & Grattoni, A 2025, , Biomaterials, vol. 317, 123110. https://doi.org/10.1016/j.biomaterials.2025.123110

Quantifying interstitial fluid by direct osmotic pressure measurements in vivo via telemetry-enabled Nanofluidic implants
Facchi, I, Di Trani, N, Hernandez, N, Joubert, AL, Wood, AM, Demarchi, D & Grattoni, A 2025, , Journal of Controlled Release, vol. 377, pp. 735-743. https://doi.org/10.1016/j.jconrel.2024.11.068

Prophylactic and therapeutic cancer vaccine with continuous localized immunomodulation
Kota, N, Gonzalez, DD, Liu, HC, Viswanath, D, Vander Pol, R, Wood, A, Di Trani, N, Chua, CYX & Grattoni, A 2024, , Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 62, 102776. https://doi.org/10.1016/j.nano.2024.102776

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
Grattoni, A, Korbutt, G, Tomei, AA, García, AJ, Pepper, AR, Stabler, C, Brehm, M, Papas, K, Citro, A, Shirwan, H, Millman, JR, Melero-Martin, J, Graham, M, Sefton, M, Ma, M, Kenyon, N, Veiseh, O, Desai, TA, Nostro, MC, Marinac, M, Sykes, M, Russ, HA, Odorico, J, Tang, Q, Ricordi, C, Latres, E, Mamrak, NE, Giraldo, J, Poznansky, MC & de Vos, P 2024, , Nature Reviews Endocrinology, vol. 21, no. 1, 4361, pp. 14-30. https://doi.org/10.1038/s41574-024-01029-0

Acoustic waves and smart biomimetic nanoparticles: combination treatment from 2D to 3D colorectal cancer models
Rosso, G, Mesiano, G, Dumontel, B, Carofiglio, M, Conte, M, Grattoni, A & Cauda, V 2024, , Cancer Nanotechnology, vol. 15, no. 1, 42. https://doi.org/10.1186/s12645-024-00281-3

3D bioprinted mesenchymal stem cell laden scaffold enhances subcutaneous vascularization for delivery of cell therapy
Bo, T, Pascucci, E, Capuani, S, Campa-Carranza, JN, Franco, L, Farina, M, Secco, J, Becchi, S, Cavazzana, R, Joubert, AL, Hernandez, N, Chua, CYX & Grattoni, A 2024, , Biomedical Microdevices, vol. 26, no. 3, 29, pp. 29. https://doi.org/10.1007/s10544-024-00713-2

Nanofluidic delivery implant sustains localization and maximizes efficacy of intratumoral immunotherapy
Liu, HC, Di Trani, N, Conte, M, Nguyen, DC, Jokonya, S, Wu, A, Vander Pol, R, Joubert, AL, Facchi, I, Wood, AM, Ho, J, Pesaresi, F, Cauda, V, Chen, SH, Liu, X, Stayton, PS, Chua, CYX & Grattoni, A 2024, , Nano Today, vol. 56, 102258. https://doi.org/10.1016/j.nantod.2024.102258

Modeling of a Bioengineered Immunomodulating Microenvironment for Cell Therapy
Capuani, S, Campa-Carranza, JN, Hernandez, N, Chua, CYX & Grattoni, A 2024, , Advanced Healthcare Materials, pp. e2304003. https://doi.org/10.1002/adhm.202304003

Engineering platforms for localized long-acting immune modulation
Chua, CYX, Viswanath, DI, Huston, DP & Grattoni, A 2024, , Journal of Allergy and Clinical Immunology, vol. 153, no. 3, pp. 572-575. https://doi.org/10.1016/j.jaci.2024.01.004

Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling
Cho, SW, Malick, H, Kim, SJ & Grattoni, A 2024, , Journal of Investigative Dermatology, vol. 144, no. 8, pp. 1707-1715. https://doi.org/10.1016/j.jid.2024.01.031

Advanced material technologies for space and terrestrial medicine
Chua, CYX, Jimenez, M, Mozneb, M, Traverso, G, Lugo, R, Sharma, A, Svendsen, CN, Wagner, WR, Langer, R & Grattoni, A 2024, , Nature Reviews Materials, vol. 9, no. 11, pp. 808-821. https://doi.org/10.1038/s41578-024-00691-0

Nanoparticle contrast-enhanced computed tomography and magnetic resonance imaging of vascularization of a subcutaneous niche for islet transplantation
Capuani, S, Campa-Carranza, JN, Hernandez, N, Menon, RTR, Bhavane, R, Rome, GE, Devkota, L, Ghaghada, KB, Annapragada, AV, Chua, CYX, Badachhape, AA & Grattoni, A 2024, , Bioengineering and Translational Medicine. https://doi.org/10.1002/btm2.10740

System Integration of an Implantable Drug Delivery Device for Long-Term In-Vivo Experiments
Del Bono, F, Di Trani, N, Demarchi, D, Grattoni, A & Ros, PM 2024, . in 2024 IEEE Sensors, SENSORS 2024 - Conference Proceedings. Proceedings of IEEE Sensors, Institute of Electrical and Electronics Engineers Inc. 2024 IEEE Sensors, SENSORS 2024, Kobe, Japan, 10/20/24. https://doi.org/10.1109/SENSORS60989.2024.10785116

Antiviral potency of long-acting islatravir subdermal implant in SHIV-infected macaques
Pons-Faudoa, FP, Di Trani, N, Capuani, S, Facchi, I, Wood, AM, Nehete, B, DeLise, A, Sharma, S, Shelton, KA, Bushman, LR, Chua, CYX, Ittmann, MM, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC & Grattoni, A 2024, , Journal of Controlled Release, vol. 366, pp. 18-27. https://doi.org/10.1016/j.jconrel.2023.12.031

Intratumoral nanofluidic system enhanced tumor biodistribution of PD-L1 antibody in triple-negative breast cancer
Liu, H-C, Capuani, S, Badachhape, AA, Di Trani, N, Davila Gonzalez, D, Vander Pol, RS, Viswanath, DI, Saunders, S, Hernandez, N, Ghaghada, KB, Chen, S-H, Nance, E, Annapragada, AV, Chua, CYX & Grattoni, A 2023, , Bioengineering and Translational Medicine, vol. 8, no. 6, e10594, pp. e10594. https://doi.org/10.1002/btm2.10594


Long-acting refillable nanofluidic implant confers protection against SHIV infection in nonhuman primates
Pons-Faudoa, FP, Trani, ND, Capuani, S, Campa-Carranza, JN, Nehete, B, Sharma, S, Shelton, KA, Bushman, LR, Abdelmawla, F, Williams, M, Roon, L, Nerguizian, D, Chua, CYX, Ittmann, MM, Nichols, JE, Kimata, JT, Anderson, PL, Nehete, PN, Arduino, RC & Grattoni, A 2023, , Science translational medicine, vol. 15, no. 702, eadg2887, pp. eadg2887. https://doi.org/10.1126/scitranslmed.adg2887

Changes in local tissue microenvironment in response to subcutaneous long-acting delivery of tenofovir alafenamide in rats and non-human primates
Pons-Faudoa, FP, Di Trani, N, Capuani, S, Hernandez, N, Wood, AM, Nehete, B, Niles, J, Shelton, KA, Kezar, S, Bushman, LR, Chua, CYX, Ittmann, MM, Anderson, PL, Nehete, PN, Arduino, RC, Nichols, JE & Grattoni, A 2023, , Journal of Controlled Release, vol. 358, pp. 116-127. https://doi.org/10.1016/j.jconrel.2023.04.037

Local Delivery of Drugs in a 3D Bioengineered Subcutaneous Niche: Biodistribution and Pharmacokinetics.
Capuani, S, Hernandez, N, Paez-Mayorga, J, Dogra, P, Wang, Z, Cristini, V, Chua, CYX, Nichols, J & Grattoni, A 2023, , 8th Nano Today Conference, San Diego, United States, 4/22/23 - 4/25/23.

Sustained Intratumoral Administration of Agonist CD40 Antibody Overcomes Immunosuppressive Tumor Microenvironment in Pancreatic Cancer
Liu, HC, Davila Gonzalez, D, Viswanath, DI, Vander Pol, RS, Saunders, SZ, Di Trani, N, Xu, Y, Zheng, J, Chen, SH, Chua, CYX & Grattoni, A 2023, , Advanced Science, vol. 10, no. 9, 2206873, pp. e2206873. https://doi.org/10.1002/advs.202206873

Languages

  • English
  • Italian