PS-OC CTO Core 1

Biomathematics Core

This core provides mathematical tools to model and predict the behavior of small molecules and nano-sized particulate systems. It will examine the following: 

• Transport dynamics within the authentic patient-specific vasculature accounting for the specific/non-specific adhesive interactions with the vascular endothelium and for the permeability of the vessel walls to both plasma and blood-borne agents
• Extravasation from the vascular compartment to the extravascular matrix through active (transcytosis) and passive (intravascular gaps) mechanism
• Transport across the extravascular matrix and distribution within the tumor microenvironment
• Control of the tumor growth and angiogenic response
• Heat generation through remote RF/NIR activation with modeling of thermal cell damage and apoptosis.