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Yitian Xu, PhD

Instructor in Nanomedicine, Academic Institute
Instructor, Research Institute
Houston Methodist


Publications

5-Hydroxymethylcytosine in Cell-Free DNA Predicts Immunotherapy Response in Lung Cancer
Shao, J, Xu, Y, Olsen, RJ, Kasparian, S, Sun, K, Mathur, S, Zhang, J, He, C, Chen, SH, Bernicker, EH & Li, Z 2024, , Cells, vol. 13, no. 8, 715. https://doi.org/10.3390/cells13080715

LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy
Mai, S, Hodges, A, Chen, HM, Zhang, J, Wang, YL, Liu, Y, Nakatsu, F, Wang, X, Fang, J, Xu, Y, Davidov, V, Kang, K, Pingali, SR, Ganguly, S, Suzuki, M, Konopleva, M, Prinzing, B, Zu, Y, Gottschalk, S, Lu, Y, Chen, SH & Pan, PY 2023, , Cancer research, vol. 83, no. 24, pp. 4047-4062. https://doi.org/10.1158/0008-5472.CAN-22-2483

Molecular architecture of proliferative lupus nephritis as elucidated using 50-plex imaging mass cytometry proteomics
Louis Sam Titus, ASC, Tan, Y, Tran, P, Lindblom, J, Ivbievbiokun, M, Xu, Y, Zheng, J, Parodis, I, Cai, Q, Chang, A, Chen, S-H, Zhao, M & Mohan, C 2023, , Clinical immunology (Orlando, Fla.), vol. 254, 109713, pp. 109713. https://doi.org/10.1016/j.clim.2023.109713

Sustained Intratumoral Administration of Agonist CD40 Antibody Overcomes Immunosuppressive Tumor Microenvironment in Pancreatic Cancer
Liu, HC, Davila Gonzalez, D, Viswanath, DI, Vander Pol, RS, Saunders, SZ, Di Trani, N, Xu, Y, Zheng, J, Chen, SH, Chua, CYX & Grattoni, A 2023, , Advanced Science, vol. 10, no. 9, 2206873, pp. e2206873. https://doi.org/10.1002/advs.202206873

Aerosolized miR-138-5p and miR-200c targets PD-L1 for lung cancer prevention
Zhang, Q, Pan, J, Xiong, D, Zheng, J, McPherson, KN, Lee, S, Huang, M, Xu, Y, Chen, S-H, Wang, Y, Hildebrandt Ruiz, L & You, M 2023, , Frontiers in immunology, vol. 14, 1166951, pp. 1166951. https://doi.org/10.3389/fimmu.2023.1166951

A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Oncolytic Virus Therapy in Metastatic Triple Negative Breast Cancer
Sun, K, Xu, Y, Mathur, S, Bernicker, EH & Chang, JC 2023, , Clinical Cancer Research.

A Phase 2 Study of In Situ Oncolytic Virus Therapy and Stereotactic Body Radiation Therapy Followed by Pembrolizumab in Metastatic Non-Small Cell Lung Cancer
Guan, J, Sun, K, Guerrero, CA, Zheng, J, Xu, Y, Mathur, S, Teh, BS, Farach, A, Zhang, J, Butler, E, Pan, PY, Zsigmond, E, Mei, Z, Mejia, J, Chen, SH, Chang, JC & Bernicker, EH 2023, , International Journal of Radiation Oncology Biology Physics, vol. 118, no. 5, pp. 1531-1540. https://doi.org/10.1016/j.ijrobp.2023.08.044

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles
Xu, Y, Zhang, L, Thaiparambil, J, Mai, S, Perera, DN, Zhang, J, Pan, P-Y, Coarfa, C, Ramos, K, Chen, S-H & El-Zein, R 2022, , Cancer research communications, vol. 2, no. 8, pp. 884-893. https://doi.org/10.1158/2767-9764.CRC-22-0057

Chemotherapy Coupled to Macrophage Inhibition Induces T-cell and B-cell Infiltration and Durable Regression in Triple-Negative Breast Cancer
Singh, S, Lee, N, Pedroza, DA, Bado, IL, Hamor, C, Zhang, L, Aguirre, S, Hu, J, Shen, Y, Xu, Y, Gao, Y, Zhao, N, Chen, SH, Wan, YW, Liu, Z, Chang, JT, Hollern, D, Perou, CM, Zhang, XHF & Rosen, JM 2022, , Cancer research, vol. 82, no. 12, pp. 2281-2297. https://doi.org/10.1158/0008-5472.CAN-21-3714

Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis
Singh, VK, Khan, A, Xu, Y, Mai, S, Zhang, L, Mishra, A, Restrepo, BI, Pan, PY, Chen, SH & Jagannath, C 2022, , Frontiers in immunology, vol. 13, 865503, pp. 865503. https://doi.org/10.3389/fimmu.2022.865503

Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome
Jewell, BE, Xu, A, Zhu, D, Huang, MF, Lu, L, Liu, M, Underwood, EL, Park, JH, Fan, H, Gingold, JA, Zhou, R, Tu, J, Huo, Z, Liu, Y, Jin, W, Chen, YH, Xu, Y, Chen, SH, Rainusso, N, Berg, NK, Bazer, DA, Vellano, C, Jones, P, Eltzschig, HK, Zhao, Z, Kaipparettu, BA, Zhao, R, Wang, LL & Lee, DF 2021, , PLoS Genetics, vol. 17, no. 12, e1009971. https://doi.org/10.1371/journal.pgen.1009971

A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer
Chung, AW, Anand, K, Anselme, AC, Chan, AA, Gupta, N, Venta, LA, Schwartz, MR, Qian, W, Xu, Y, Zhang, L, Kuhn, J, Patel, T, Rodriguez, AA, Belcheva, A, Darcourt, J, Ensor, J, Bernicker, E, Pan, PY, Chen, SH, Lee, DJ, Niravath, PA & Chang, JC 2021, , Science translational medicine, vol. 13, no. 624, abj5070. https://doi.org/10.1126/scitranslmed.abj5070

The Sympathetic Nervous System Modulates Cancer Vaccine Activity through Monocyte-Derived Cells
Hinkle, L, Liu, Y, Meng, C, Chen, Z, Mai, J, Zhang, L, Xu, Y, Pan, PY, Chen, SH & Shen, H 2021, , Journal of Immunology, vol. 207, no. 12, pp. 3131-3140. https://doi.org/10.4049/jimmunol.2100719

A heparan-sulfate-bearing syndecan-1 glycoform is a distinct surface marker for intra-tumoral myeloid-derived suppressor cells
Welte, T, Mai, J, Zhang, Z, Tian, S, Zhang, G, Xu, Y, Zhang, L, Chen, SS, Wang, T & Shen, H 2021, , iScience, vol. 24, no. 11, 103349, pp. 103349. https://doi.org/10.1016/j.isci.2021.103349

Virus-Mimic mRNA Vaccine for Cancer Treatment
Meng, C, Chen, Z, Mai, J, Shi, Q, Tian, S, Hinkle, L, Li, J, Zhang, Z, Ramirez, M, Zhang, L, Xu, Y, Zhang, J, Pan, PY, Chen, SH, Li, H & Shen, H 2021, , advanced therapeutics, vol. 4, no. 11, 2100144. https://doi.org/10.1002/adtp.202100144

Exploitation of synthetic mRNA to drive immune effector cell recruitment and functional reprogramming in vivo
Xu, Y, Huang, L, Kirschman, JL, Vanover, DA, Tiwari, PM, Santangelo, PJ, Shen, X & Russell, DG 2019, , Journal of Immunology, vol. 202, no. 2, pp. 608-617. https://doi.org/10.4049/jimmunol.1800924

Enhanced permeability and retention-like extravasation of nanoparticles from the vasculature into tuberculosis granulomas in zebrafish and mouse models
Fenaroli, F, Repnik, U, Xu, Y, Johann, K, Van Herck, S, Dey, P, Skjeldal, FM, Frei, DM, Bagherifam, S, Kocere, A, Haag, R, De Geest, BG, Barz, M, Russell, DG & Griffiths, G 2018, , ACS Nano, vol. 12, no. 8, pp. 8646-8661. https://doi.org/10.1021/acsnano.8b04433

Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis
Xu, Y, Wang, L, Zimmerman, MD, Chen, KY, Huang, L, Fu, DJ, Kaya, F, Rakhilin, N, Nazarova, EV, Bu, P, Dartois, V, Russell, DG & Shen, X 2018, , PLoS pathogens, vol. 14, no. 4, e1006974. https://doi.org/10.1371/journal.ppat.1006974

Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting
Chen, HJ, Sun, J, Huang, Z, Hou, H, Arcilla, M, Rakhilin, N, Joe, DJ, Choi, J, Gadamsetty, P, Milsom, J, Nandakumar, G, Longman, R, Zhou, XK, Edwards, R, Chen, J, Chen, KY, Bu, P, Wang, L, Xu, Y, Munroe, R, Abratte, C, Miller, AD, Gümüs, ZH, Shuler, M, Nishimura, N, Edelmann, W, Shen, X & Lipkin, SM 2015, , Nature Biotechnology, vol. 33, no. 6, pp. 656-660. https://doi.org/10.1038/nbt.3239

miR-1269 promotes metastasis and forms a positive feedback loop with TGF-ß
Bu, P, Wang, L, Chen, KY, Rakhilin, N, Sun, J, Closa, A, Tung, KL, King, S, Varanko, AK, Xu, Y, Chen, JH, Zessin, AS, Shealy, J, Cummings, B, Hsu, D, Lipkin, SM, Moreno, V, Gümüs, ZH & Shen, X 2015, , Nature Communications, vol. 6, 6879. https://doi.org/10.1038/ncomms7879

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