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Ronald W. Busuttil, MD, PhD

Emeritus Professor of Surgery, Academic Institute
Houston Methodist


Biography

Ronald W. Busuttil is the Dumont Professor of Transplantation Surgery and Chief of the Division of Liver and Pancreas Transplant in the Department of Surgery at the UCLA School of Medicine. After graduating from Loyola University in New Orleans, Dr. Busuttil earned both his M.D. and Ph.D. degrees at Tulane University. He served his surgical residency at UCLA under Dr. William Longmire and trained in transplantation with Dr. Thomas Starzl at the University of Pittsburgh.

Dr. Busuttil has been a member of the Department of Surgery at UCLA since 1978. In 1984, he established the Liver Transplant Program and has been the Director and Chief Surgeon for more than a decade. Dr. Busuttil has performed over 2000 liver transplants and is internationally known for his surgical expertise and clinical acumen. He has demonstrated a life-long commitment to the care of desperately ill patients, the training of medical students, residents, and surgical fellows; and to the scientific advancement in the field of transplantation surgery. Furthermore, Dr. Busuttil's training program in liver transplantation is currently recognized as the foremost in the world. He has trained both U.S. and international transplant surgeons, many of whom lead liver transplant programs throughout the world.

Dr. Busuttil serves as a reviewer on the editorial boards of many prestigious journals, and is the co-editor of the definitive textbook on liver transplantation, entitled Transplantation of the Liver. He has written over 40 book chapters, 300 abstracts and 350 peer-reviewed scientific publications. Ronald Busuttil is a member of many national and international surgical and transplant societies, and holds key committee memberships. Dr. Busuttil previously served as the Co-Chairman of the International Congress on Immuno-suppression and is currently President-elect for the American Society of Transplant Surgeons.

Publications

Myeloid spatial and transcriptional molecular signature of ischemia-reperfusion injury in human liver transplantation
Sosa, RA, Ahn, R, Li, F, Terry, AQ, Qian, Z, Bhat, A, Sen, S, Naini, BV, Ito, T, Kaldas, FM, Hoffmann, A, Busuttil, RW, Kupiec-Weglinski, JW, Gjertson, DW & Reed, EF 2024, , Hepatology Communications, vol. 8, no. 1, e0330. https://doi.org/10.1097/HC9.0000000000000330

Intestinal Re-Transplantation
Smullin, CP, Venick, RS, Marcus, EA, McDiarmid, SV, Yersiz, H, Busuttil, RW & Farmer, DG 2024, , Gastroenterology Clinics of North America. https://doi.org/10.1016/j.gtc.2024.01.004

Disulfide-HMGB1 signals through TLR4 and TLR9 to induce inflammatory macrophages capable of innate-adaptive crosstalk in human liver transplantation
Terry, AQ, Kojima, H, Sosa, RA, Kaldas, FM, Chin, JL, Zheng, Y, Naini, BV, Noguchi, D, Nevarez-Mejia, J, Jin, YP, Busuttil, RW, Meyer, AS, Gjertson, DW, Kupiec-Weglinski, JW & Reed, EF 2023, , American Journal of Transplantation, vol. 23, no. 12, pp. 1858-1871. https://doi.org/10.1016/j.ajt.2023.08.002

Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis
Sosa, RA, Terry, AQ, Ito, T, Naini, BV, Zheng, Y, Pickering, H, Nevarez-Mejia, J, Busuttil, RW, Gjertson, DW, Kupiec-Weglinski, JW, Reed, EF & Kaldas, FM 2023, , Transplantation Direct, vol. 9, no. 11, pp. E1550. https://doi.org/10.1097/TXD.0000000000001550

The Evolution of Redo Liver Transplantation over 35 Years: Analysis of 654 Consecutive Adult Liver Retransplants at a Single Center
Kaldas, FM, Horwitz, JK, Noguchi, D, Korayem, IM, Markovic, D, Ebaid, S, Agopian, VG, Yersiz, H, Saab, S, Han, SB, El Kabany, MM, Choi, G, Shetty, A, Singh, J, Wray, C, Barjaktarvic, I, Farmer, DG & Busuttil, RW 2023, , Annals of surgery, vol. 278, no. 3, pp. 441-451. https://doi.org/10.1097/SLA.0000000000005962

Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium
Tran, BV, Moris, D, Markovic, D, Zaribafzadeh, H, Henao, R, Lai, Q, Florman, SS, Tabrizian, P, Haydel, B, Ruiz, RM, Klintmalm, GB, Lee, DD, Taner, CB, Hoteit, M, Levine, MH, Cillo, U, Vitale, A, Verna, EC, Halazun, KJ, Tevar, AD, Humar, A, Chapman, WC, Vachharajani, N, Aucejo, F, Lerut, J, Ciccarelli, O, Nguyen, MH, Melcher, ML, Viveiros, A, Schaefer, B, Hoppe-Lotichius, M, Mittler, J, Nydam, TL, Markmann, JF, Rossi, M, Mobley, C, Ghobrial, M, Langnas, AN, Carney, CA, Berumen, J, Schnickel, GT, Sudan, DL, Hong, JC, Rana, A, Jones, CM, Fishbein, TM, Busuttil, RW, Barbas, AS & Agopian, VG 2023, , Liver Transplantation, vol. 29, no. 7, pp. 683-697. https://doi.org/10.1097/LVT.0000000000000145

HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma
Sun, N, Zhang, C, Lee, YT, Tran, BV, Wang, J, Kim, H, Lee, J, Zhang, RY, Wang, JJ, Hu, J, Zhang, Z, Alsudaney, MS, Hou, KC, Tang, H, Zhang, TX, Liang, IY, Zhou, Z, Chen, M, Yeh, AHJ, Li, W, Zhou, XJ, Chang, HR, Han, SHB, Sadeghi, S, Finn, RS, Saab, S, Busuttil, RW, Noureddin, M, Ayoub, WS, Kuo, A, Sundaram, V, Al-Ghaieb, B, Palomique, J, Kosari, K, Kim, IK, Todo, T, Nissen, NN, Tomasi, ML, You, S, Posadas, EM, Wu, JX, Wadehra, M, Sim, MS, Li, Y, Wang, HL, French, SW, Lu, SC, Wu, L, Pei, R, Liang, L, Yang, JD, Agopian, VG, Tseng, HR & Zhu, Y 2023, , Hepatology, vol. 77, no. 3, pp. 774-788. https://doi.org/10.1002/hep.32692

Gsk3ß regulates the resolution of liver ischemia/reperfusion injury via MerTK
Zhang, H, Ni, M, Wang, H, Zhang, J, Jin, D, Busuttil, RW, Kupiec-Weglinski, JW, Li, W, Wang, X & Zhai, Y 2023, , JCI insight, vol. 8, no. 1, e151819. https://doi.org/10.1172/jci.insight.151819

Outcomes in liver transplant recipients with nonalcoholic fatty liver disease-related HCC: results from the US multicenter HCC transplant consortium
US Multicenter HCC Transplant Consortium 2023, , Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, vol. 29, no. 1, pp. 34-47. https://doi.org/10.1097/LVT.0000000000000007

Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference
ERAS4OLT.org collaborative 2023, , The Lancet Gastroenterology and Hepatology, vol. 8, no. 1, pp. 81-94. https://doi.org/10.1016/S2468-1253(22)00268-0

Low-dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation
Oberkofler, CE, Raptis, DA, Müller, PC, Sousa da Silva, RX, Lehmann, K, Ito, T, Owen, T, Pollok, JM, Parente, A, Schlegel, A, Peralta, P, Winter, E, Selzner, M, Fodor, M, Maglione, M, Jaklitsch, M, Marques, HP, Chavez-Villa, M, Contreras, A, Kron, P, Lodge, P, Alford, S, Rana, A, Magistri, P, Di Benedetto, F, Johnson, B, Kirchner, V, Bauldrick, F, Halazun, KJ, Ghamarnedjad, O, Mehrabi, A, Basto, ST, Fernandes, ESM, Paladini, J, de Santibañes, M, Florman, S, Tabrizian, P, Dutkowski, P, Clavien, PA, Busuttil, RW, Kaldas, FM & Petrowsky, H 2022, , Liver Transplantation, vol. 28, no. 12, pp. 1888-1898. https://doi.org/10.1002/lt.26534

New ERAS in liver transplantation – Past, present, and next steps
the ERAS4OLT.org Working Group: Claus Niemann, San Francisco, CA, USA, Joerg-Matthias Pollok, London, UK,Marina Berenguer, Valencia, Spain, Jonathan Potts, London, UK, and Carlo Frola, London, UK 2022, , Clinical Transplantation, vol. 36, no. 10, e14625. https://doi.org/10.1111/ctr.14625

Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma
Tabrizian, P, Holzner, ML, Mehta, N, Halazun, K, Agopian, VG, Yao, F, Busuttil, RW, Roberts, J, Emond, JC, Samstein, B, Brown, RS, Najjar, M, Chapman, WC, Doyle, MM, Florman, SS, Schwartz, ME & Llovet, JM 2022, , JAMA Surgery, vol. 157, no. 9, pp. 779-788. https://doi.org/10.1001/jamasurg.2022.2800

A 3-Decade, Single-Center Experience of Liver Transplantation for Cholangiocarcinoma: Impact of Era, Tumor Size, Location, and Neoadjuvant Therapy
Ito, T, Butler, JR, Noguchi, D, Ha, M, Aziz, A, Agopian, VG, DiNorcia, J, Yersiz, H, Farmer, DG, Busuttil, RW, Hong, JC & Kaldas, FM 2022, , Liver Transplantation, vol. 28, no. 3, pp. 386-396. https://doi.org/10.1002/lt.26285

Fractional Flow Reserve in End-Stage Liver Disease
Kumar, P, Kim, JS, Gordin, J, Honda, HM, Suh, W, Lee, MS, Press, M, Nsair, A, Aksoy, O, Busuttil, RW, Tobis, J & Parikh, RV 2022, , American Journal of Cardiology, vol. 166, pp. 122-126. https://doi.org/10.1016/j.amjcard.2021.11.031

Circulating Tumor Cell–Based Messenger RNA Scoring System for Prognostication of Hepatocellular Carcinoma: Translating Tissue-Based Messenger RNA Profiling Into a Noninvasive Setting
Lee, YT, Sun, N, Kim, M, Wang, JJ, Tran, BV, Zhang, RY, Qi, D, Zhang, C, Chen, PJ, Sadeghi, S, Finn, RS, Saab, S, Han, SHB, Busuttil, RW, Pei, R, Zhu, Y, Tseng, HR, You, S, Yang, JD & Agopian, VG 2022, , Liver Transplantation, vol. 28, no. 2, pp. 200-214. https://doi.org/10.1002/lt.26337

Perioperative Skeletal Muscle Fluctuations in High-Acuity Liver Transplantation
Chong, J, Guorgui, J, Coy, H, Ito, T, Lu, M, DiNorcia, J, Agopian, VG, Farmer, DG, Raman, SS, Busuttil, RW & Kaldas, FM 2022, , Journal of Surgical Research, vol. 270, pp. 386-393. https://doi.org/10.1016/j.jss.2021.09.030

Operational tolerance is not always permanent: A 10-year prospective study in pediatric liver transplantation recipients
Wozniak, LJ, Venick, RS, Naini, BV, Scapa, J, Hickey, MJ, Rossetti, M, Korin, Y, Reed, EF, Farmer, DG, Busuttil, RW, Vargas, JH & McDiarmid, SV 2022, , Liver Transplantation, vol. 28, no. 10, pp. 1640-1650. https://doi.org/10.1002/lt.26474

Sarcopenia in high acuity liver transplantation: Does it predict outcomes?
Ito, T, Guorgui, J, Markovic, D, Coy, H, Younan, SM, DiNorcia, J, Agopian, VG, Farmer, DG, Raman, SS, Busuttil, RW & Kaldas, FM 2022, , Clinical Transplantation, vol. 36, no. 1, e14503. https://doi.org/10.1111/ctr.14503

How to Handle Arterial Conduits in Liver Transplantation? Evidence from the First Multicenter Risk Analysis
Oberkofler, CE, Raptis, DA, Dinorcia, J, Kaldas, FM, Müller, PC, Pita, A, Genyk, Y, Schlegel, A, Muiesan, P, Tun Abraham, ME, Dokus, K, Hernandez-Alejandro, R, Rayar, M, Boudjema, K, Mohkam, K, Lesurtel, M, Esser, H, Maglione, M, Vijayanand, D, Lodge, JPA, Owen, T, Malagó, M, Mittler, J, Lang, H, Khajeh, E, Mehrabi, A, Ravaioli, M, Pinna, AD, Dutkowski, P, Clavien, PA, Busuttil, RW & Petrowsky, H 2021, , Annals of surgery, vol. 274, no. 6, pp. 1032-1042. https://doi.org/10.1097/SLA.0000000000003753

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