Kavindra V. Singh

Kavindra V. Singh, PhD

Research Professor of Medicine, Academic Institute
Full Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faecium
Axell-House, DB, Simar, SR, Panesso, D, Rincon, S, Miller, WR, Khan, A, Pemberton, OA, Valdez, L, Nguyen, AH, Hood, KS, Rydell, K, DeTranaltes, AM, Jones, MN, Atterstrom, R, Reyes, J, Sahasrabhojane, PV, Suleyman, G, Zervos, M, Shelburne, S, Singh, KV, Shamoo, Y, Hanson, BM, Tran, TT & Arias, CA 2024, , Antimicrobial Agents and Chemotherapy, vol. 68, no. 3. https://doi.org/10.1128/aac.01069-23

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis
Miller, WR, Nguyen, A, Singh, KV, Rizvi, S, Khan, A, Erickson, SG, Egge, S, Cruz, MR, Dinh, A, Diaz, L, Zhang, R, Xu, L, Garsin, DA, Shamoo, Y & Arias, CA 2023, , bioRxiv, pp. 1 - 30. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614854/>

Colocalization of Linezolid Resistance (cfr) and Virulence Factors Cytolysin and Hemolysin (cln and hln) on a Plasmid in Enterococcus faecalis
Singh, NV, Singh, KV, Dinh, AQ, Arias, CA, Shropshire, WC, Hanson, BM & Murray, BE 2023, , Antimicrobial Agents and Chemotherapy, vol. 67, no. 6, pp. e0025923. https://doi.org/10.1128/aac.00259-23

Evaluation of Cefazolin High Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus (MSSA) Using Gold standard MICs and Rapid Colorimetric Test (RCT)
Malikazad, H, Rizvi, S, Venugopalan, V, Santevechi, B, Panesso, D, Singh, KV, Gomez, S, Tran, C, Jacques-Palaz, KD, Miller, WR & Arias, CA 2023, , 6th Annual Texas Medical Center Antimicrobial Resistance and Stewardship Conference, January 18-20, 2023, Houston, United States, 1/18/23 - 1/20/23.

Optimization of a Nitrocefin-Based Rapid Test for the Detection of the Cefazolin Inoculum Effect (CzIE) in MSSA
Villegas, SG, Panesso, D, Singh, KV, Rincon, S, Carvajal, LP, Jacques-Palaz, KD, Rizvi, S, Reyes, MI, Abbott, A, Burnham, CAD, Bard, JD, Westblade, LF, Fritz, S, Zimmer, B, Dingle, TC, Butler-Wu, S, Miller, WR, Reyes, J & Arias, CA 2023, , IDWeek 2023 , Boston, United States, 10/11/23 - 10/15/23.

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium
Axell-House, DB, Simmar, S, Rincon, S, Miller, WR, Khan, A, Pemberton, O, Valdez, L, Nguyen, A, Hood, KS, Rydell, K, DeTranaltes, AM, Jones, MN, Atterstrom, R, Reyes, J, Sahasrabhojane, P, Suleyman, G, Zervos, MJ, Shelburne, SA, Singh, KV, Shamoo, Y, Hanson, BM, Tran, C & Arias, CA 2023, , bioRxiv.

Evaluation of Cefazolin High Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus (MSSA) Using Gold standard MICs and Rapid Colorimetric Test (RCT)
Singh, KV 2023, , 6th Annual Texas Medical Center Antimicrobial Resistance and Stewardship Conference, January 18-20, 2023, Houston, United States, 1/18/23 - 1/20/23 pp. 1.

LiaF is required for LiaX mediated protection against daptomycin and LL-37 in Enterococcus faecalis OG1RF
Panesso, D, Singh, KV, Villegas, SG, Khan, A, Supandy, A, Nguyen, AH, Rincon, S, Wood, K, Dinh, A, Research, H, Miller, WR, Shamoo, Y, Tran, C & Arias, CA 2022, . in LiaF is required for LiaX mediated protection against daptomycin and LL-37 in Enterococcus faecalis OG1RF. <https://www.eventscribe.net/2022/IDWeek/searchGlobal.asp>

Enterococcus faecium Clade Competition in the Presence of ß-Lactam Antibiotics in a Mouse GI Tract Colonization Model
Singh, KV, Murray, B & Montealegre, MC 2022, , Antimicrobial Agents and Chemotherapy, vol. 66, no. 11, https://doi.org/10.1128/aac.00903-22, pp. 1 - 5. https://doi.org/10.1128/aac.00903-22

Activation of the Enterococcus faecalis Cell Envelope Stress Response through the Novel MadRS System Is Associated With Increased Size of Cardiac Microlesions
Miller, WR, Singh, KV & Arias, CA 2021, . in Activation of the Enterococcus faecalis Cell Envelope Stress Response through the Novel MadRS System Is Associated With Increased Size of Cardiac Microlesions. vol. 8, PMCID: PMC8644875, Open Forum Infect Dis. USA. https://doi.org/10.1093/ofid/ofab466.1196

Polymorphisms in Key Regulatory Regions of the bla operon Correlate with the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus (MSSA)
Gomez-Villegas, SI, Rios, R, Diaz, L, Dinh, A, Panesso, D, Rincon, S, Carvajal, LP, Reyes, MI, Murray, BE, Miller, WR, Singh, KV, Reyes, J & Arias, CA 2021, . https://doi.org/doi: 10.1093/ofid/ofab466.199

Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model
Singh, KV, Arias, CA & Murray, BE 2021, , Antimicrobial Agents and Chemotherapy, vol. 65, no. 9, 00709, pp. e0070921. https://doi.org/10.1128/AAC.00709-21

Efficacy of omadacycline against escherichia coli in a mouse urinary tract infection model
Singh, KV & Murray, BE 2021, , Antimicrobial Agents and Chemotherapy, vol. 65, no. 7, e00269-21. https://doi.org/10.1128/AAC.00269-21

Development and Characterization of High-Throughput Caenorhabditis elegans – Enterococcus faecium Infection Model
Revtovich, AV, Tjahjono, E, Singh, KV, Hanson, BM, Murray, BE & Kirienko, NV 2021, , Frontiers in cellular and infection microbiology, vol. 11, 667327. https://doi.org/10.3389/fcimb.2021.667327

Cardiac microlesions form during severe bacteremic enterococcus faecalis infection
Brown, AO, Singh, KV, Cruz, MR, Kaval, KG, Francisco, LE, Murray, BE & Garsin, DA 2021, , Journal of Infectious Diseases, vol. 223, no. 3, pp. 508-516. https://doi.org/10.1093/infdis/jiaa371

Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis
Murphy, EL, Singh, KV, Avila, B, Kleffmann, T, Gregory, ST, Murray, BE, Krause, KL, Khayat, R & Jogl, G 2020, , Scientific Reports, vol. 10, no. 1, 16301. https://doi.org/10.1038/s41598-020-73199-6

Mechanistic Insights into the Differential Efficacy of Daptomycin plus ß-Lactam Combinations against Daptomycin-Resistant Enterococcus faecium
Kebriaei, R, Stamper, KC, Singh, KV, Khan, A, Rice, SA, Dinh, AQ, Tran, TT, Murray, BE, Arias, CA & Rybak, MJ 2020, , Journal of Infectious Diseases, vol. 222, no. 9, pp. 1531-1539. https://doi.org/10.1093/infdis/jiaa319

Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible staphylococcus aureus bacteremia
Ulloa, ER, Singh, KV, Geriak, M, Haddad, F, Murray, BE, Nizet, V & Sakoulas, G 2020, , Clinical Infectious Diseases, vol. 71, no. 6, pp. 1413-1418. https://doi.org/10.1093/cid/ciz995

Tedizolid as step-down therapy following daptomycin versus continuation of daptomycin against enterococci and methicillin- And vancomycin-resistant Staphylococcus aureus in a rat endocarditis model
Singh, KV, Arias, CA & Murray, BE 2020, , Antimicrobial Agents and Chemotherapy, vol. 64, no. 5, e02303-19. https://doi.org/10.1128/AAC.02303-19

Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA
Sales, MJ, Sakoulas, G, Szubin, R, Palsson, B, Arias, C, Singh, KV, Murray, BE & Monk, JM 2020, , Microbiology Resource Announcements, vol. 9, no. 18, e01515-19. https://doi.org/10.1128/MRA.01515-19