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Alexandra J. Walsh, PhD

Adjunct Assistant Professor of Cardiovascular Sciences, Academic Institute
Assistant Affiliate Member, Research Institute
Houston Methodist


Publications

Autofluorescence is a biomarker of neural stem cell activation state
Morrow, CS, Tweed, K, Farhadova, S, Walsh, AJ, Lear, BP, Roopra, A, Risgaard, RD, Klosa, PC, Arndt, ZP, Peterson, ER, Chi, MM, Harris, AG, Skala, MC & Moore, DL 2024, , Cell Stem Cell, vol. 31, no. 4, pp. 570-581.e7. https://doi.org/10.1016/j.stem.2024.02.011

3D convolutional neural networks predict cellular metabolic pathway use from fluorescence lifetime decay data
Hu, L, De Hoyos, D, Lei, Y, West, AP & Walsh, AJ 2024, , APL Bioengineering, vol. 8, no. 1, 016112. https://doi.org/10.1063/5.0188476

Autofluorescence intensity imaging for studying mitochondrial dynamics
Ter Hofstede, B, Galloway, A & Walsh, AJ 2024, . in NT Shaked & O Hayden (eds), Label-free Biomedical Imaging and Sensing (LBIS) 2024., 128540V, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12854, SPIE, 2024 Label-free Biomedical Imaging and Sensing, LBIS 2024, San Francisco, United States, 1/27/24. https://doi.org/10.1117/12.3003064

Characterization of a multispectral visible imaging system for monitoring perfusion changes in dogs under anesthesia
Bullard, EA, Benavides, OR, Stout, EM, Watt, M, Dickerson-Bagley, V & Walsh, AJ 2024, . in NT Shaked & O Hayden (eds), Label-free Biomedical Imaging and Sensing (LBIS) 2024., 1285406, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12854, SPIE, 2024 Label-free Biomedical Imaging and Sensing, LBIS 2024, San Francisco, United States, 1/27/24. https://doi.org/10.1117/12.3000088

Perfusability and immunogenicity of implantable pre-vascularized tissues recapitulating features of native capillary network
Sharma, D, Sharma, A, Hu, L, Chen, TA, Voon, S, Bayless, KJ, Goldman, J, Walsh, AJ & Zhao, F 2023, , Bioactive Materials, vol. 30, pp. 184-199. https://doi.org/10.1016/j.bioactmat.2023.07.023

Label-free optical imaging of cell function and collagen structure for cell-based therapies
Hu, L, Morganti, S, Nguyen, U, Benavides, OR & Walsh, AJ 2023, , Current Opinion in Biomedical Engineering, vol. 25, 100433. https://doi.org/10.1016/j.cobme.2022.100433

Volumetric imaging of human mesenchymal stem cells (hMSCs) for non-destructive quantification of 3D cell culture growth
Benavides, OR, Gibbs, HC, White, BP, Kaunas, R, Gregory, CA, Walsh, AJ & Maitland, KC 2023, , PLoS ONE, vol. 18, no. 3, e0282298, pp. e0282298. https://doi.org/10.1371/journal.pone.0282298

POSEA: A novel algorithm to evaluate the performance of multi-object instance image segmentation
Wang, N, Hu, L & Walsh, AJ 2023, , PLoS ONE, vol. 18, no. 3, e0283692, pp. e0283692. https://doi.org/10.1371/journal.pone.0283692

Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state
Yu, W, Chen, Y, Putluri, N, Osman, A, Coarfa, C, Putluri, V, Kamal, AHM, Asmussen, JK, Katsonis, P, Myers, JN, Lai, SY, Lu, W, Stephan, CC, Powell, RT, Johnson, FM, Skinner, HD, Kazi, J, Ahmed, KM, Hu, L, Threet, A, Meyer, MD, Bankson, JA, Wang, T, Davis, J, Parker, KR, Harris, MA, Baek, ML, Echeverria, GV, Qi, X, Wang, J, Frederick, AI, Walsh, AJ, Lichtarge, O, Frederick, MJ & Sandulache, VC 2023, , British Journal of Cancer, vol. 128, no. 11, pp. 2013-2024. https://doi.org/10.1038/s41416-023-02253-7

Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression
Liu, L, Zhou, Y, Liu, Z, Li, J, Hu, L, He, L, Gao, G, Kidd, B, Walsh, A, Jiang, R, Wu, C, Zhang, K & Xie, L 2023, , CMGH, vol. 15, no. 5, pp. 1117-1133. https://doi.org/10.1016/j.jcmgh.2022.12.010

Identifying cancer cell metabolic states in autofluorescence lifetime images with machine learning
Hu, L & Walsh, AJ 2023, . in NT Shaked & O Hayden (eds), Label-free Biomedical Imaging and Sensing (LBIS) 2023., 1239104, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12391, SPIE, Label-free Biomedical Imaging and Sensing (LBIS) 2023, San Francisco, United States, 1/28/23. https://doi.org/10.1117/12.2648436

Label-free spatially maintained measurements of metabolic phenotypes in cells
Hu, L, Wang, N, Bryant, JD, Liu, L, Xie, L, West, AP & Walsh, AJ 2023, , Frontiers in Bioengineering and Biotechnology, vol. 11, 1293268. https://doi.org/10.3389/fbioe.2023.1293268

Comparison of phasor analysis and biexponential decay curve fitting of autofluorescence lifetime imaging data for machine learning prediction of cellular phenotypes
Hu, L, Ter Hofstede, B, Sharma, D, Zhao, F & Walsh, AJ 2023, , Frontiers in Bioinformatics, vol. 3, 1210157. https://doi.org/10.3389/fbinf.2023.1210157

Effects of Short Pulses of Infrared Light on Metabolic Coenzyme Binding
Martinez, J, Theodossiou, AM & Walsh, AJ 2023, . in Optical Manipulation and Its Applications, OMA 2023. Optical Manipulation and Its Applications, OMA 2023, Optical Society of America, Optical Manipulation and Its Applications, OMA 2023 - Part of Optica Biophotonics Congress: Optics in the Life Sciences 2023, Vancouver, Canada, 4/24/23. https://doi.org/10.1364/OMA.2023.AM2D.3

Decellularized organ biomatrices facilitate quantifiable in vitro 3D cancer metastasis models
VandenHeuvel, SN, Farris, HA, Noltensmeyer, DA, Roy, S, Donehoo, DA, Kopetz, S, Haricharan, S, Walsh, AJ & Raghavan, S 2022, , Soft Matter, vol. 18, no. 31, pp. 5791-5806. https://doi.org/10.1039/d1sm01796a

Identification of rare cell populations in autofluorescence lifetime image data
Cardona, EN & Walsh, AJ 2022, , Cytometry Part A, vol. 101, no. 6, pp. 497-506. https://doi.org/10.1002/cyto.a.24534

In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish
Miskolci, V, Tweed, KE, Lasarev, MR, Britt, EC, Walsh, AJ, Zimmerman, LJ, McDougal, CE, Cronan, MR, Fan, J, Sauer, JD, Skala, MC & Huttenlocher, A 2022, , eLife, vol. 11, e66080. https://doi.org/10.7554/ELIFE.66080

Modeling key metabolic pathways of cancer cells using label-free fluorescence lifetime imaging
Hu, L & Walsh, AJ 2022, . in NT Shaked & O Hayden (eds), Label-free Biomedical Imaging and Sensing (LBIS) 2022., 1197206, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11972, SPIE, Label-free Biomedical Imaging and Sensing (LBIS) 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2608760

Autofluorescence imaging to evaluate cellular metabolism
Theodossiou, A, Hu, L, Wang, N, Nguyen, U & Walsh, AJ 2021, , Journal of Visualized Experiments, no. 177, e63282. https://doi.org/10.3791/63282

Extracellular pH affects the fluorescence lifetimes of metabolic co-factors
Schmitz, R, Tweed, K, Walsh, C, Walsh, AJ & Skala, MC 2021, , Journal of Biomedical Optics, vol. 26, no. 5, 056502. https://doi.org/10.1117/1.JBO.26.5.056502

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