Research

Milestones

 

  • 2022 Fellow of the Year Houston Methodist Neal Cancer Canter Hematology Oncology Fellowship
    • Ryan Kieser, MD
  • 2022 Abstract Achievement Award, Houston Methodist Cancer Center Symposium
    • Ethan Burns, MD
  • 2022 Wadi Suki Foundation community Scholar Award
    • Ethan Burns, MD
  • 2022 Jerold B. Katz Foundation’s Houston Methodist 2022 Humanitas Award
    • Ethan Burns, MD
  • 2022 Houston Methodist Cancer Center Nurses’ Choice Award
    • Ethan Burns, MD
  • 2022 FDA/ASCO Fellows’ Day Workshop
    • Zimu Gong, MD
  • 2022  Research Award of Excellence Houston Methodist Neal Cancer Center Hematology Medical Oncology Fellowship
    • Kai Sun, MD
  • 2022 ASCO Conquer Cancer Foundation Young Investigator Award
    • Kai Sun, MD
  • 2021 Research Award of Excellence Houston Methodist Neal Cancer Center Hematology Medical Oncology Fellowship
    • Kai Sun, MD
  • 2021 Fellow of the Year Houston Methodist Neal Cancer Center Hematology Medical Oncology Fellowship
    • Kai Sun, MD
  • 2021  Nurses’ Choice Award Houston Methodist Hospital
    • Ethan A. Burns, MD
  • 2021 AACR/ACO Vail Recipient
    • Kai Sun, MD
  • 2021 ASCO Merit Award
    • Kai Sun, MD
  • 2021  ASCO/FDA Fellow’s Clinical Workshop
    • Kai Sun
  • 2021 Burroughs Wellcome Fund Fellow
    • Kai Sun, MD
  • 2021 ASCO Conquer Cancer Merit Award
    • Carlo Guerrero, MD
    • Akshjot Puri, MD
  • 2020 ASCO Advocacy Summit
    • Abeer Arain, MD
  • 2020 Research Award of Excellence Houston Methodist Cancer Center Hematology Medical Oncology Fellowship
    • Akshjot Puri, MD
  • 2020  Fellow of the Year Houston Methodist Cancer Center Hematology Medical Oncology Fellowship
    • Kai Sun, MD
  • 2020  Nurses’ Choice Award Houston Methodist Hospital
    • Carlo Guerrero, MD
  • 2019  Research Award of Excellence Houston Methodist Cancer Center Hematology Medical Oncology Fellowship
    • Kartik Anand, MD
  • 2019  Fellow of the Year Houston Methodist Cancer Center Hematology Medical Oncology Fellowship
    • Cesar Gentille, MD
  • 2019 Nurses’ Choice Award Houston Methodist Hospital
    • Sarah Lynn Creamer, MD
  • ASCO/FDA Fellow’s Clinical Workshop. November, 2020. Silver Springs, MD
    • Akshjot Puri, M.D.
  • ICML International Conference of Malignant Lymphoma (Switzerland):
    • Kartik Anand M.D.: Comprehensive report of anti-CD19 chimeric antigen receptor T-cells (CAR-T) associated Non Relapse Mortality (CART-NRM) from FAERS
  • ASCO 2019
    • Emre Koca M.D.: Phase II Trial Of Neoadjuvant TAK-228 Plus Tamoxifen In Patients With (ER)-Positive, HER2-Negative Breast Cancer. MERIT AWARD
    • Kartik Anand M.D.: Comprehensive report of anti-CD19 chimeric antigen receptor T cells (CAR-T) associated non-relapse mortality (CART-NRM) from FAERS. MERIT AWARD
    • Kartik Anand M.D. Neoadjuvant Phase II study of Everolimus plus Cisplatin in TNBC patients with Residual Disease
  • ASCO-SITC (Society of Immunotherapy of Cancer) 2019
    • Kartik Anand M.D.: T-cell lymphoma secondary to CPI use for other malignancies. MERIT AWARD
  • Houston Methodist Cancer Symposium 2018
    • Sarah Creamer M.D.: Best clinical Trial Poster Award
  • Texas ASCO 2018
    • Emre Koca M.D.: Association of PRAME expression with clinical features in uveal melanoma ($1000 Award)

 

 

2019 ASCO Vail Recipients

 

  • Emre Koca M.D. Phase I study of autologous T lymphocytes expressing GD2-specific chimeric antigen treatment of patients with pre-treated metastatic uveal melanoma patients.
  • Akshjot Puri M.D. Neurocognitive and Neuroimaging Assessments in Investigating the Mechanism of Cancer-Related Cognitive Impairment in Breast Cancer

 

 

Publications To Date

 

  1. Kai Sun, Yitian Xu, Licheng Zhang, Eric H. Bernicker, Jenny C. Chang, et al. A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Oncolytic Virus Therapy in Metastatic Triple Negative Breast Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-22-0622.

  2. Xiangliang Yuan, Yimin Duan, Yi Xiao, Kai Sun, Dihua Yu et al. Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. Cancer Discov. 2022 Apr 14; candisc.0900.2021. doi: 10.1158/2159-8290.CD-21-0900. Pubmed ID: 35420681.Impact factor 39.4.  

  3. Kai Sun, Charisma Mylavarapu, Aubrey Crenshaw, Yuqi Zhang, Enshuo Hsu, Jiaqiong Xu, Marilyn Niravath, Juan Carlos Nicolas, Stephen Jones, Adriana Ordonez, Maen Abdelrahim. Pancreatic head versus pancreatic body/tail cancer: are they different? World J Gastrointest Oncol. March 15,2022;14(3);716-723. Doi: 10.4251/wjgo.v14.i3.716. Pubmed ID: 35321276. 

  4.  Guo M, Liu J, Miao R, Ahmed Z, Yu J, Guan J, Ahmad S, Zhou S, Grove A, Manoucheri M, Socinski MA, Mekhail T. A Single Center Retrospective Study of the Impact of COVID-19 Infection on Immune-related Adverse Events in Cancer Patients Receiving Immune Checkpoint Inhibitors. J Immunother. 2022 Sep 5. doi: 10.1097/CJI.0000000000000440. Epub ahead of print. PMID: 36066505.

  5. Tao L, Miao R, Mekhail T, Sun J, Meng L, Fang C, Guan J, Jain A, Du Y, Allen A, Rzeszutko BL, Socinski MA, Chang CC. Prognostic Value of KRAS Mutation Subtypes and PD-L1 Expression in Patients With Lung Adenocarcinoma. Clin Lung Cancer. 2021 Jul;22(4):e506-e511. PMID: 32807653.

  6. Mylavarapu C, Lu AJ, Burns EA, Samorajski J, Gotur D, Baker K. Diffuse Cerebral Edema and Impending Herniation Complicating Hepatic Encephalopathy in Hereditary Hemorrhagic Telangiectasia. Case Rep Med. 2022 Feb 18;2022:2612544. doi: 10.1155/2022/2612544. PMID: 35222647

  7.  Chitturi KR, Burns EA, Muhsen IN, Anand K, Trachtenberg BH. Cardiovascular Risks with Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors and Monoclonal Antibody Therapy. Curr Oncol Rep. 2022 Apr;24(4):475-491. doi: 10.1007/s11912-022-01215-Epub 2022 Feb 22. PMID: 35192115. 

  8. Burns EA, Ensor JE, Hsu J, Thomas JS, Olsen RJ, Bernicker EH. Outcomes and prognostic contributors in patients with KRAS mutated non-small cell pulmonary adenocarcinomas: a single institution experience. J Thorac Dis. 2021 Aug;13(8):4785- 4796. doi: 10.21037/jtd-21-432. PMID: 34527319 13. 

  9.  Hsu J, Annunziata JF, Burns EA, Bernicker EH, Olsen RJ, Thomas JS. Molecular Signatures of KRAS-Mutated Lung Adenocarcinoma: Analysis of Concomitant EGFR, ALK, STK11, and PD-L1 Status. Clin Pathol. 2022 May 23;15:2632010X221102054. doi: 10.1177/2632010X221102054. PMID: 35634237; PMCID: PMC9134433.

  10. Sarfraz H, Gentille C, Ensor J, Wang L, Wong S, Ketcham MS, Joshi J, Pingali SRK. Primary cutaneous anaplastic large-cell lymphoma: a review of the SEER database from 2005 to 2016 Clin Exp Dermatol. 2021 Jun 3. doi: 10.1111/ced.14777. Online ahead of print.PMID: 34081802
  11. Puri A, Chang J, Tanner N, Lucente P, Desiongco J, Dragovich T, Naraev B, Kundranda M. Skeletal metastases in advanced pancreatic ductal adenocarcinoma (PDAC): A retrospective analysis. J Gastrointestin Oncol. 2021 Apr; 12(2): 455-463
  12. Melissa Yan, Ryan Kieser, Carol C. Wu, Wei Qiao, Cristhiam M. Rojas-Hernandez; Clinical factors and outcomes of subsegmental pulmonary embolism in cancer patients. Blood Adv 2021; 5 (4): 1050–1058. doi: https://doi.org/10.1182/bloodadvances.2020003136
  13. Sarfraz H, Arain A, Divatia MK, Schwartz MR, Heyne KE. Metastatic colorectal carcinoma to the right atrium: a case report and review of the literature. Cardiooncology. 2021 May 31;7(1):21. doi: 10.1186/s40959-021-00108-9. PMID: 34059136; PMCID: PMC8165980.
  14. Mina SA, Muhsen IN, Burns EA, Sarfaraz H, Pingali SR, Xu J, Hashmi SK. Post-Marketing Analysis of Peripheral Neuropathy Burden with Newer Generation Proteasome Inhibitors Using the FDA Adverse Event Reporting System (FAERS). Turk J Haematol. 2021 Jun 30. doi: 10.4274/tjh.galenos.2021.2021.0052
  15. Yu KH, Hendifar AE, Alese OB, Draper A, Abdelrahim M, Burns EA, Khan G, Cockrum P, Bhak RH, Nguyen C, DerSarkissian M, Duh MS and Bahary N. Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Treated With Liposomal Irinotecan. Front. Oncol. 2021;11:678070. doi: 10.3389/fonc.2021.678070
  16. Burns EA, Gentille C, Trachtenberg B, Pingali SR, Anand K. Cardiotoxicity Associated with Anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Recognition, Risk Factors, and Management. Diseases. 2021; 9(1):20. https://doi.org/10.3390/diseases9010020
  17. Burns EA, Koca E, Xu J, McLean E, Lee R, Patel T, Chang J, Niravath P. Measuring Ovarian Escape in Premenopausal Estrogen Receptor-Positive Breast Cancer Patients on Ovarian Suppression Therapy. Oncologist. 2021 Feb 16;. doi: 10.1002/onco.13722.
  18. Burns EA, Muhsen IN, Anand K, Xu J, Umoru G, Arain AN, Abdelrahim M. Hepatitis B Virus Reactivation in Cancer Patients Treated with Immune Checkpoint Inhibitors. J Immunother. 2021 Jan 19. doi: 10.1097/CJI.0000000000000358
  19. Kai Sun, Humaira Sarfraz, Maen Abdelrahim. Complete response of metastatic pancreatic cancer in a CHEK2 mutation carrier treated with platinum-based therapy- A case report and literature review. Br J Gastroenterol. 2020;2(4): 194-198.doi: 10.31488/bjg.1000121.
  20. Anand K, Sahu G, Burns EA, Ensor A, Ensor J, Pingali SR, Subbiah V, Iyer SP. Mycobacterial Infections due to PD-1 and PD-L1 checkpoint inhibitors. ESMO Open 2020;5:e000866. doi: 10.1136/esmoopen-2020-000866
  21. Burns EA, Abdelrahim M. The Rising Tide of Pancreatic Adenocarcinoma: A Review of Risk Factors, Diagnostic Challenges, and Treatment Updates. J Cancer Biol. 2020; 1(2): 23-27\
  22. Kasparian S, Burns EA, Shehabeldin A, Awar M, Pingali SR. Recurrent Small Bowel Obstruction Caused by Burkitt Lymphoma. J Med Case Rep. 2020 Aug 12;14(1):127. doi: 10.1186/s13256-020-02449-y.
  23. Kasparian S, Gentille C, Burns EA, Bernicker H. Hyperprogressive non-small cell lung cancer with two immune checkpoint inhibitors. JTO Clinical and Research Reports. 2020: 1; 2, 100017.
  24. Arain A, Muhsen IN, Abdelrahim M. Acquired haemophilia as a paraneoplastic manifestation of pancreatic cancer. Ecancermedicalscience. 2020 Jun 4;14:1053. doi: 10.3332/ecancer.2020.1053. PMID: 32582368; PMCID: PMC7302889.
  25. Arain A. Smoking among breast cancer survivors. Breast J. 2020 Dec;26(12):2452-2453. doi: 10.1111/tbj.14107. Epub 2020 Nov 28. PMID: 33248446.
  26. Puri A, Kamble RT, Pingali SR. Individualizing Approach to Primary CNS Lymphoma. Diagnosis and Treatment: Hematology Journal. 2020 (1): 23-32. 10.33513/DTHJ/2001-03
  27. Gentille C, Anand K, Dalwadi S, Puri A, Farach A, Pingali SR. Radiation therapy in primary mediastinal large B-cell lymphoma treated with DA-R-EPOCH Clin Case Rep. 2020 Apr 13;8(7):1153-1155. doi: 10.1002/ccr3.2853. eCollection 2020 Jul.PMID: 32695347
  28. Mooneyham J, Gentille C, Barbieri A, Shah S. Use of rituximab in lymphomatoid granulomatosis with isolated central nervous system involvement BMJ Case Rep. 2020 Sep 7;13(9):e235412. doi: 10.1136/bcr-2020-235412.PMID: 32900727
  29. Guerrero C, Jain T, Kelemen K. HHV-8-Associated Lymphoproliferative Disorders and Pathogenesis in an HIV-Positive Patient.
    Case Rep Hematol. 2019;2019:4536157. Published 2019 Aug 22. doi:10.1155/2019/4536157
  30. Puri A, Reddy T, Patel TA, Chang JC. Metastatic triple negative breast cancer: Established and Emerging Treatments. The breast journal. In Press
  31. Puri A, Kamble RT, Pingali SR. Individualizing Approach to Primary CNS Lymphoma. Diagnosis and Treatment: Hematology journal. In Press
  32. Kai Sun, Ryan J Reynolds, Tiffany G Sheu, Jessica A Thomsula, Laura Colton, Lawrence Rice. Acute myeloid leukemia presenting as acute liver failure- a case report and literature review.
    Ecancermedicalscience. 2019 Sep 9; 13:960. https://doi.org /10.3332/ecancer.2019.960. Pubmed ID: 31645888
  33. Gentille C, Anand K, Dalwadi S, Puri A, Farach A, Pingali S. Radiation therapy in primary mediastinal large B‐cell lymphoma treated with DA‐R‐EPOCH.
    Clinical case reports. 2020 April; doi: https://doi.org/10.1002/ccr3.2853.
  34. Kasparian S, Gentille C, Burns E, Bernicker EH. Hyperprogressive non-small cell lung cancer with two immune-checkpoint inhibitors.
    JTO Clinical and Research Reports. 2020 February; doi: https://doi.org/10.1016/j.jtocrr.2020.100017
  35. Burns EA, Gentille C, Kasparian S, Pingali SR. A Case of Histiocytic Sarcoma Arising from Mycosis Fungoides.
    Case Rep Hematol. 2019;2019:7834728. doi: 10.1155/2019/7834728. eCollection 2019. PubMed PMID: 31687231; PubMed Central PMCID: PMC6794960
  36. Schefler A, Koca E, Bernicker E, Correa Z. Relationship between clinical features, GEP class and PRAME expression in uveal melanoma.  Graefe’s Archive for clinical and experimental opthomology. 2019; 1-5.
  37. Anand K, Kumar P, Pingali SR et al. Acute myeloid leukemia with eosinophilia after cyclin-dependent kinases 4/6 inhibitor treatment due to underlying clonal hematopoiesis of indeerminate potential. Am J Hematol 2019; 94: E82-E85.
  38. Anand K, Niravath P. Acupuncture and Vitamin D for the Management of Aromatase Inhibitor-Induced Arthralgia. Curr Oncol Rep 2019; 21: 51.
  39. Anand K, Ibrahim I. Four Limb Ischemia: A Severe Case of Heparin Induced Thrombocytopenia. Indian J Hematol Blood Transfus 2019; 35: 397-398.
  40. Burns E, Anand K, Acosta G et al. Autosplenectomy in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH). Case Rep Hematol 2019; 2019: 3146965.
  41. Wallis CJ, Satkunasivam R, Butaney M, Khan UA, Goldberg HA..Klaassen et al. Association between smoking and survival benefit of immunotherapy in advanced malignancies: A systemic review and meta-analysis. American Journal of Cliniacl Oncology 2019 September; 42(9): 711-716
  42. Patel, TA, Ensor JE, Creamer SL, Boone T..Chang JC. A randomized, controlled phase II trial of neoadjuvant ado-trastuzumab emtansine, lapatinib and nab-paclitaxel versus trastuzumab, pertuzumab, and paclitaxel in HER2 positive breast cancer (TEAL study). Breast cancer research 2019 Sept 2; 21(1):100
  43. Kasparian S, Anand K, Burns E, Chung B, Pingali SRK. Macrophage Activation Syndrome Secondary to Underlying Sarcoidosis. 2019 Jun 18; 11(6)
  44. Anand K, Roszik J, Hall C…Patel S. Pilot Study of Circulating Tumor cells in Early Stage and Metastatic Uveal Melanoma. Cancers (Basel). 2019 Jun 20; 11(6)
  45. Anand K, Pingali SR, Trachtenberg B, Iyer SP. Complete Response to R-EPOCH in Primary Cardiac Lymphoma. Case R Hematology 2019 April 10.
  46. Anand, K, Ibrahim I. Four Lim Ischemia: A severe case of Heparin Induced Thrombocytopenia.  Indian J Hematology Blood Transfusion 2019 April