Stanley H. Appel, MD
Stanley H. Appel, MD
About Dr. Stanley H. Appel
Dr. Appel is former chair of the Stanley H. Appel Department of Neurology. He is the director of the Ann Kimball & John W. Johnson Center for Cellular Therapeutics. Professor of Neurology at Weill Cornell Medical College, and the Peggy and Gary Edwards Distinguished Chair for the Treatment and Research of ALS at the Houston Methodist Research Institute. He was previously Chair of the Department of Neurology at Baylor College of Medicine as well as Chief of the Neurology division and the James B. Duke Professor of Medicine at Duke University Medical Center, North Carolina.
An internationally renowned researcher and neurologist, Dr. Appel is dedicated to the treatment of patients with ALS and is one of the nation's foremost experts on the disease. He has spent more than 40 years devoted to understanding the human brain. Dr. Appel is creator and director of what is now the Houston Methodist Neurological Institute's MDA/ALSA ALS Research and Clinical Center in Houston. Established in 1982, the center was the first multidisciplinary clinic dedicated to ALS patient care and research in the United States. Dr. Appel's laboratory focuses on developing new insights into ALS, Parkinson's disease, and Alzheimer's disease, and was the first to document regulatory T-lymphocytes modulate disease progression in ALS patients. His focus is on enhancing the protective immunity of T-reg cells and anti-inflammatory microglia in neurodegeneration.
Dr. Appel has written 15 books and more than 400 articles. His achievements include the Gold Medal for Excellence in Biomedical Research from Columbia College of Physicians and Surgeons, Sheila Essey Award for ALS Research, Texas Neurological Society Lifetime Achievement Award, Forbes Norris Award from the International Alliance of ALS/MND Associations and John P. McGovern Compleat Physician Award from the Houston Academy of Medicine.
Clinical Interests
Amyotrophic lateral sclerosis (ALS)
Alzheimer’s disease
Neuromuscular diseases
Accepted Insurance Plans
- (WELLMED) AARP MEDICARE ADVANTAGE ESSENTIALS FROM UHC EP-1 (PPO) **
- (WELLMED) AARP MEDICARE ADVANTAGE EXTRA FROM UHC EP-3 (PPO) **
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC EP-2 (PPO) **
- (WELLMED) AARP MEDICARE ADVANTAGE CareFlex FROM UHC TX-44 (HMO-POS)**
- (WELLMED) AARP MEDICARE ADVANTAGE CareFlex FROM UHC TX-45 (HMO-POS)**
- (WELLMED) AARP MEDICARE ADVANTAGE ESSENTIAL FROM UHC TX-21 (HMO-POS)**
- (WELLMED) AARP MEDICARE ADVANTAGE ESSENTIAL FROM UHC TX-22 (HMO-POS)**
- (WELLMED) AARP MEDICARE ADVANTAGE EXTRA FROM UHC TX-27 (HMO-POS)**
- (WELLMED) AARP MEDICARE ADVANTAGE EXTRA FROM UHC TX-28 (HMO-POS)**
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-35 (HMO-POS) **
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-38(HMO-POS) **
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-39 (HMO-POS) **
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-40 (HMO-POS) **
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-41 (HMO-POS) **
- (WELLMED) AARP MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-47 (HMO-POS) **
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-31 (PPO)** H1278-005
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-31 (PPO)** H1278-013
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-31 (PPO)** H1278-014
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-31 (PPO)** H1278-021
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-31 (PPO)** H1278-025
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-31 (PPO)** H1278-026
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-32 (PPO)** H1278-022
- (WELLMED) MEDICARE ADVANTAGE GIVEBACK FROM UHC TX-34 (PPO)** H1278-024
- (WELLMED) SECURE HORIZON MEDICARE ADVANTAGE TX-0023 (HMO-POS)**
- (WELLMED) SECURE HORIZON MEDICARE ADVANTAGE TX-0025 (HMO-POS)**
- Aetna Affordable Health Choices
- Aetna APCN Plus Multi-Tier HM Tier 2
- Aetna Choice POS / Open Choice
- Aetna Common Spirit Minimum Value Plan
- Aetna CommonSpirit Health KelseyCare
- Aetna EPO
- Aetna Health Network
- Aetna HMO
- Aetna International
- Aetna Managed Choice / Elect Choice
- Aetna Medicare Advantage HMO
- Aetna Medicare Advantage PPO
- Aetna Medicare Dual Complete Plan (HMO D-SNP)
- Aetna Medicare HMO Prime
- Aetna Meritain Hlth/Aetna Premier Care (APCN)
- Aetna Open Access
- Aetna POS
- Aetna PPO
- Aetna Premier Care Network
- Aetna QPOS
- Aetna Select
- Aetna Signature Administrators
- Aetna Signature Administrators Allied Benefits
- Aetna Signature Administrators CoreSource
- Aetna Signature Administrators EBMS
- Aetna Signature Administrators MODA
- Aetna Student Health
- Aetna Transplant
- Aetna TX Pref Plus II Network
- Aetna Workers' Comp
- All Saver/United Healthcare
- BCBS PPO GUIDESTONE
- BCBS PPO Wespath
- Best Doctors International
- Bind Surest UHC
- Blue Choice POS
- Blue Choice PPO
- Blue Cross Blue Shield EPO
- Blue Cross Blue Shield FEP Federal Employee Plan
- Blue Cross Blue Shield Medicare Advantage Out of State
- Blue Cross Blue Shield Medicare Advantage PPO/UT Care
- Blue Cross Blue Shield POS
- Blue Cross Blue Shield PPO
- Blue Edge
- Blue Essentials
- Blue Essentials Access
- CareWorks Workers' Comp
- Cigna Allegiance Houston Methodist Employee Medical Plan
- Cigna Allegiance OAP
- Cigna Allegiance PPO
- Cigna APWU
- Cigna C-24 Network
- Cigna Choice Fund
- Cigna EPO
- Cigna Global Health Benefits (International)
- Cigna Great West
- Cigna HMO
- Cigna Indemnity
- Cigna LocalPlus
- Cigna NALC
- Cigna Network
- Cigna Network Open Access
- Cigna Open Access
- Cigna Open Access Plus (OAP)
- Cigna POS
- Cigna PPO
- Cigna Qualcare
- Cigna Shared Administration OAP
- Cigna Shared Administration PPO
- Cigna SureFit
- Community Health Choice Medicare Advantage HMO DSNP
- Community Health Choice PREMIER Gold
- Community Health Choice PREMIER Silver
- Coventry PPO
- DEVOTED CORE 001 TX (HMO)
- DEVOTED CORE 019 TX (HMO)
- DEVOTED C-SNP Plus 031 TX (HMO C-SNP)
- DEVOTED C-SNP Premium 030 TX (HMO C-SNP)
- DEVOTED DUAL 010 TX (HMO D-SNP)
- DEVOTED DUAL FULL 040 (HMO D-SNP)
- DEVOTED GIVEBACK 006 TX (HMO)
- DEVOTED HEALTH DUAL PLUS GREATER HOUSTON
- DEVOTED PREMIUM 002 (HMO)
- Entrust/90 Degree EDI Payer ID# 36878
- First Health PPO
- GeoBlue
- HAA Preferred Partners (International)
- HealthSmart Accel PPO
- HealthSmart Payors Organization
- HealthSmart PPO
- Healthspring/Cigna MCR HMO
- Healthspring/Cigna MCR PPO
- Healthspring/Cigna MCR Total Care Dual
- HMO Blue
- Humana Medicare Advantage Choice PPO
- Humana Medicare Advantage Gold Plus/Choice
- Humana Medicare Advantage HMO
- Humana Medicare Advantage PPO
- Humana TRICARE 2
- Kelsey Seybold Affiliate Network
- Medica Choice with UnitedHealthcare Choice Plus
- Medicare
- MEDICARE ADVANTAGE : TEXAN PLUS
- Medicare Railroad
- Molina Healthcare of TX CHIP MCD
- Molina Healthcare STAR+PLUS MCD
- Molina Healthcare TX STAR MCD
- Molina Marketplace Exchange
- Molina Medicare Complete Care HMO (Dual) HIDE
- Molina Medicare Complete Care Plus (HMO Dual-SNP) FIDE
- MultiPlan PPO
- Olympus Managed Care (International)
- PHCS Healthy Directions
- PHCS MEDI-SHARE
- PHCS PPO
- PHCS/Multiplan Practitioner & Ancillary Only
- ProCare Medicare Advantage
- Reny Company Workers' Comp
- Sana Benefits
- Student Assurance Services Student Accident Plan
- Texas Kids First /Fidelity Security Student Accident Plan
- Texas Monarch/Web TPA Student Accident Plan
- Three Rivers Provider Network
- TRS-ActiveCare 2 Group 385002
- TRS-ActiveCare Fully Insured Plan-South Texas Region Group 295430
- TRS-ActiveCare Fully Insured Plan-West Texas Region Group 295781
- TRS-ActiveCare HD Group 385000
- TRS-ActiveCare Primary Group 385003
- TRS-ActiveCare Primary Plus Group 385001
- TRS-Care Standard ALT A I Group 485002
- TRS-Care Standard ALT A II Group 485003
- TRS-Care Standard ALT B I Group 485005
- TRS-Care Standard ALT B II Group 485006
- TRS-Care Standard CMED Group 485001
- TRS-Care Standard Group 485000
- TX Annual Conf of UMC-UMR
- UHC COMPLETE CARE SUPPORT TX-1A (REGIONAL PPO C-SNP)** R6801-008
- UHC Complete Care TX-16 (HMO-POS C-SNP)** H4527-039
- UHC Complete Care TX-17 (HMO-POS C-SNP)** H4527-040
- UHC Complete Care TX-18 (HMO-POS C-SNP)** H4527-041
- UHC Complete Care TX-19 (HMO-POS C-SNP)** H4527-042
- UHC COMPLETE CARE TX-29 (REGIONAL PPO C-SNP)** R6801-009
- UHC DUAL COMPLETE TX-S001 (REGIONAL PPO D-SNP)** R6801-011
- UHC GR MA HALLIBURTON HMO 137 ** H0609-822-137
- UHC GR MA LOCKHEED HMO 164 ** H0609-822-164
- UHC GR MA RIO TINTO SERVICE
- UHC GR MA TEACHER RETIREMENT SYSTEM HMO 199** H0609-822-207
- UHC GR MA VERIZON HMO 207** H0609-822-207
- UHC MEDICARE ADVANTAGE TX-0030 (REGIONAL PPO)** R6801-012
- UMR
- United Health Integrated Services
- United HealthCare Community Plan Dual Complete (HMO SNP)
- United Healthcare Nexus ACO RA or OA
- United Healthcare Plan of the River Valley
- UnitedHealthcare Choice
- UnitedHealthcare ChoicePlus
- UnitedHealthcare Core
- UnitedHealthcare Core Plus
- UnitedHealthcare EPO
- UnitedHealthcare Golden Rule
- UnitedHealthcare HMO
- UnitedHealthcare Navigate
- UnitedHealthcare Navigate Plus
- UnitedHealthcare Options PPO
- UnitedHealthcare Oxford
- UnitedHealthcare POS
- UnitedHealthcare PPO
- UnitedHealthcare Student Resources
- UnitedHealthcare West
- UnitedHealthOne
- US Family Health Plan
- WellMed AARP Medicare Advantage Choice PPO
- WellMed AARP Medicare Advantage Plan 1 & Plan 2
- WellMed Medicare Advantage Choice PPO
- WellMed Medicare Advantage Patriot
- WellMed UHC Dual Complete HMO D-SNP
- WellMed UnitedHealthCare Dual Complete Choice (Regional PPO D-SNP)
- WellMed UnitedHealthCare Medicare Advantage Choice (Regional PPO)
- WellMed UnitedHealthCare Medicare Gold (Regional PPO C-SNP)
- WellMed UnitedHealthCare Medicare Silver (Regional PPO C-SNP)
- Wellpoint Chronic Care (HMO C-SNP)
- Wellpoint Dual Advantage (HMO D-SNP)
- Wellpoint Dual Advantage 2 (HMO D-SNP)
- WELLPOINT ESSENTIALS MARKETPLACE
- Wellpoint Full Dual Advantage (HMO D-SNP)
- Wellpoint Full Dual Advantage 2 (HMO D-SNP)
- Wellpoint Home Care (HMO C-SNP)
- Wellpoint Kidney Care (HMO C-SNP)
- Wellpoint Kidney Care (HMO-POS C-SNP)
- Wellpoint Lung Care (HMO C-SNP)
- Wellpoint Medicare Advantage 2 (HMO)
- Wellpoint Select (HMO)
- Workers' Comp: Coventry / First Health
Credentials
- Neurology | American Board of Psychiatry and Neurology
- Columbia University College of Physicians and Surgeons - New York, NY | 1960
- Massachusetts General Hospital - Boston, MA
- Neurology | Mount Sinai Medical Center - Miami Beach, FL
- Duke University Medical Center - Durham, NC
- Houston Methodist Hospital
- Houston Methodist Neurological Institute
- Peggy and Gary Edwards Distinguished Chair in ALS Research, Stanley H. Appel Department of Neurology
- Professor of Neurology, Academic Institute
- Member, Research Institute, Academic Institute
- Director, Ann Kimball & John W. Johnson Center for Cellular Therapeutics
- Houston Methodist
- Weill Cornell Medical College
Languages
- English