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Types and Causes of Blood Cancer

There are three main types of blood cancer: leukemia, lymphoma and myeloma.

Leukemia  is cancer of the blood or bone marrow. It includes four main types:

 

  • Acute lymphoblastic leukemia (ALL)
  • Acute myeloid leukemia (AML)
  • Chronic lymphocytic leukemia (CLL)
  • Chronic myeloid leukemia (CML)

 

Leukemia occurs due to excessive production of abnormal white blood cells in the bone marrow. This limits the ability of the bone marrow to produce enough red blood cells (which carry oxygen and remove carbon dioxide) and platelets (needed for blood clotting).

Lymphoma  is a blood cancer that affects the lymphatic system — tissues, organs, glands (lymph nodes) and vessels that collect and filter excess fluid (called lymph) and return it back into the bloodstream as plasma. As part of the immune system, the lymphatic system also produces white blood cells.

 

Lymphoma includes two main types: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.

Lymphoma occurs when abnormal white blood cells grow out of control, eventually accumulating to levels that negatively affect the function of your lymph nodes, spleen and liver.

Myeloma  is also called multiple myeloma, due to its appearance in more than one location. This is cancer of plasma cells — types of white (immune) blood cells.

Myeloma occurs when plasma cells (antibody-producing white blood cells) in the bone marrow become abnormal and grow uncontrollably. Their growth limits the ability for bone marrow to produce healthy blood cells and platelets.

Abnormal plasma cells don't produce functional antibodies. Instead, they produce nonfunctional antibodies that cause issues as their levels expand.

Nationally Ranked for Cancer Care


Houston Methodist Hospital is nationally ranked by U.S. News & World Report for cancer. In addition, we are considered high performing by U.S. News & World Report for leukemia, lymphoma and myeloma.

 

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Why Choose Houston Methodist for Blood Cancer Treatment

Why Choose Houston Methodist for Blood Cancer Treatment

Our multidisciplinary team of cancer experts provides innovative care, delivered with compassion. Oncology nurse navigators guide you through every stage of blood cancer care — from diagnosis through treatment. 

Hematologists, oncologists and other specialists work together to develop a personalized treatment plan tailored to your needs. We use advanced diagnostics and treatment options — including molecular testing, immunotherapy and stem cell transplant — to stop your cancer as quickly and safely as possible.

Our pioneering research and clinical trials result in new therapies developed to combat cancer. Houston Methodist patients may access clinical trials offering potentially promising treatments not available to the public.

Blood Cancer Treatments

If you receive a blood cancer diagnosis, your oncology care team will tailor your treatment plan to the unique characteristics of your type of blood cancer. We also consider your individual needs and lifestyle, with the goal of providing effective treatments while preserving healthy tissue and cells. Your care team may use one or more methods to treat and manage your cancer.
Chemotherapy is the primary mode of treatment for leukemia. It is also often used to treat lymphoma and multiple myeloma. Chemotherapy uses drugs to stop the growth or cancer cells by killing them or halting cell division and growth.
Radiation therapy is a cancer treatment using high-energy X-rays or other types of radiation to kill cancer cells or stop them from growing. Radiation works by targeting abnormal cells, damaging their DNA so they are unable to reproduce. In combination with chemotherapy, radiation therapy is often used to treat blood-related cancers.
Immunotherapy uses medications to stimulate the immune system. The drugs help the body to produce more immune cells or help existing immune cells recognize and destroy cancerous cells. Numerous types of immunotherapies can be used to treat cancer, either alone or in combination with other treatments.
A bone marrow transplant — also known as a stem cell transplant — may be used to treat leukemia, lymphoma or multiple myeloma. The transplant replaces damaged bone marrow with healthy stem cells, allowing for higher doses of chemotherapy, when a more aggressive approach is needed.

Targeted Therapy

Targeted therapy is a newer type of treatment for leukemia and lymphoma. It uses drugs that specifically recognize and target cancer cells without harming normal cells.

Blood Cancer Education

Blood cancers account for about 10% of all diagnosed cancers in the U.S. each year, and are more common in men than women. Here’s some additional information that you should know:
  • Blood Cancer Awareness
  • Blood Cancer Stages
  • Risk Factors for Blood Cancer
  • Blood Cancer Awareness

    Blood Cancer Awareness

    Despite more than a million people across the globe experiencing the pain of a blood cancer diagnosis every year, awareness of the disease is still incredibly low.

    That’s because blood cancer a complicated group of cancers, including lymphoma, leukemia and myeloma. And it can affect anyone, at any age, at any time.
  • Blood Cancer Stages

    Understanding the Stages of Blood Cancer

    There are four stages of blood cancer:

     

    Stage 1 – The lymph nodes are enlarged. The risk at this stage is low because the cancer has not spread or affected any other organs.
    Stage 2 – One or more organs are enlarged, including the lymph nodes, liver and spleen. Lymphocyte growth is high.
    Stage 3 – Anemia develops in this stage and more than two organs are affected.
    Stage 4 – This is the highest risk stage with a rapid decrease in red blood cells and platelets. Lungs and other organs are affected. Anemia is likely to be acute.

     

    The stage your doctor assigns depends on the symptoms you are experiencing and the rate of metastasis (the spread of cancer cells from where they first formed in your body).

  • Risk Factors for Blood Cancer

    Risk Factors for Blood Cancer

    A risk factor is anything that increases your odds of developing blood cancer, including genetic, environmental and lifestyle factors. It is important to be aware of your individual risk factors.

    Risk factors vary by type of leukemia, lymphoma or myeloma. Common factors include age, race and sex, chemical or radiation exposure, autoimmune disorders, family history and more.

    Learn more about blood cancer risk factors >

Houston Methodist Blood Cancer Experts

Our highly skilled team of blood cancer specialists, including medical, surgical and radiation oncologists, nurses, nurse navigators, and support staff, have vast experience researching and treating all blood cancer stages and types. They work together as a collaborative team to create the most effective treatment plan for your specific blood cancer.

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    Leukemia, Lymphoma & Myeloma FAQs

    How common is blood cancer?

    According to the National Foundation for Cancer Research, an estimated 187,740 new cases of blood cancer will be diagnosed in the United States in 2024. Leukemia, lymphoma and myeloma account for approximately 10% of all new cancer diagnoses.

    Is blood cancer curable?

    Yes, blood cancer can be curable, depending on the type and how soon you receive treatment. Early diagnosis can improve your treatment options and outcomes. 

    Certain blood cancers are uncurable, such as chronic lymphocytic leukemia, chronic myeloid leukemia and myeloma. If a cancer is not curable, the focus is on treating the condition and putting it into remission (reduced or eliminated symptoms).

    Survival rates vary, depending on your overall health, age and response to treatment. According to the National Cancer Institute, the five-year relative survival rate (percentage of people alive five years after diagnosis) is:

     

    • Leukemia – 67%
    • Non-Hodgkin lymphoma – 74%
    • Hodgkin lymphoma – 89%
    • Myeloma – 61%

    Why are early screening tests not available for blood cancer?

    There are no early screening tests available for blood cancers like leukemia, lymphoma or myeloma due to these factors:

     

    • the complexity and variability of these diseases
    • the diverse types and presentations of blood cancers
    • the lack of universally accepted biomarkers for early detection

     

    Unlike some solid tumors, such as breast cancer or prostate cancer, blood cancers have multiple subtypes with varying characteristics and progression patterns. This makes it challenging to develop a one-size-fits-all screening test.

    There is an absence of reliable and specific biomarkers. Current biomarkers are useful to monitor disease progression and response to treatment, though not for early detection.

    How can I reduce my risk of developing blood cancer?

    While we cannot change certain risk factors such as age or genetics, we can reduce risk by avoiding exposure to radiation and harmful chemicals, not smoking, and managing infections and autoimmune conditions.

    Attend regular medical checkups and consultations with your health care provider for personalized risk assessments and prevention tactics.

    Is blood cancer contagious?

    No, blood cancer is not contagious. You cannot “catch” leukemia, lymphoma or myeloma from someone else.