Nanomedicine Research

 

At Houston Methodist, our goal is to bring nanotechnologies to the clinic. By using interdisciplinary methods to combine nanoengineering, mathematical modeling and biomedical sciences, we develop nanotechnology-enabled therapeutic and diagnostic platforms to combat diseases including cancer, diabetes, cardiovascular and infectious diseases. Our main strategies are to make it possible for clinicians to detect disease early from blood proteomic signatures through the use of nanochips, to produce injectable nanovectors for targeted therapies and to design and create intelligent implants that allow controlled, time-released doses of substances. We have also created nanoscale scaffolding to aid in bone tissue engineering.

Recent Highlights
Through our research, we are also attempting to understand the physics of mass transport within a cancer lesion and mass exchanges between cancer and surrounding host biology in order to create better nanomedicine treatments for cancer. We use several core facilities to advance our research goals; Molecular Diagnostics, Nanoengineering and Peptidomics-Nanoengineering to name just a few.
nano device
Remote-Controlled Drug Delivery Implant May Help Chronic Disease Management
Houston Methodist scientists led by Alessandro Grattoni, PhD, successfully delivered dosages of chronic disease medications using a nanochannel delivery system controlled remotely via Bluetooth technology.
carbon fiber
Space Study Focuses on Potential Biomedical, Aerospace Applications
Houston Methodist researchers are test-driving Lamborghini's carbon fiber materials in space.
Smaller than a grain of rice, this tiny device, invented by a Houston Methodist nanoscientist, delivers immunotherapy straight into a tumor, eliminating both side effects and the need for multiple IV treatments.
Scientists Create Nanodevice to Deliver Immunotherapy Without Side Effects
Houston Methodist scientists led by Alessandro Grattoni, PhD, have developed a nanodevice to deliver immunotherapy without side effects to treat triple-negative breast cancer.
Listen to Houston Methodist Researcher on STEM on Fire Podcast
STEM on Fire, a weekly podcast that features experts in science, technology, engineering and math, featured Houston Methodist nanomedicine researcher Alessandro Grattoni, PhD.

12

Faculty With Academic Appointments

39

Peer-reviewed Publications in 2024

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