Dr. Olsen’s laboratory studies the molecular pathogenesis of invasive group A Streptococcus (GAS) infections, such as necrotizing fasciitis (NF, also termed “flesh-eating disease”). Despite marked advances in the study of GAS genetics and epidemiology, the key molecular pathways and host-pathogen interactions mediating GAS virulence in invasive deep soft tissue infections remain largely undefined.

Dr. Olsen’s laboratory uses an integrated molecular approach to study transcriptional regulators and virulence factors important for GAS NF. Whole-genome sequence analysis, genome-wide transcript analysis (RNA sequencing), Luminex-based human serum protein profiling, tissue microarray examination, flow cytometric analysis, in vivo molecular imaging, quantitative microbial culture, and in vitro immunologic assays are used to study specimens derived from preclinical models and human patients.

The long-term goal of Dr. Olsen's research is to aid the development of new diagnostic tools, vaccine strategies, and therapeutic agents that will significantly improve patient care.