Jun Li Lab
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About Our Lab
Summary of Research
In addition to his own work, Li has a passion for mentoring students, post-doctoral scientists, and junior faculty. Many of his trainees have become independent investigators in academic institutions.
He is a newly elected counselor of AUPN and a current member of the American Neurological Association Board of Directors. He has also served as a member of the Scientific Advisory Board for the Muscular Dystrophy Association and the Charcot-Marie-Tooth Association, and the scientific committee of the Peripheral Nerve Society. He has been a member of NIH study sections for more than a decade.
Research Areas
- Inherited Peripheral Nerve Diseases
- Myelin Biology
- Peripheral Nerve Electrophysiology
- Electromyogram
- Nerve Conduction Study
- Peripheral Nerve Quantitative MRI (QMRI) to Track Myelin and Axon Pathology
- Automation of Quantification of Peripheral Nerve Pathology
Summary of Research
Dr. Jun Li's research has two arms – basic science studies and clinical research. The basic science studies focus on a better understanding of myelin biology and its applications in inherited peripheral nerve diseases, identification of molecular targets, and therapeutic development.
Clinical Research
Basic Studies
Currently, we are studying several genes and their related CMT disease using multiple in vitro and in vivo models in our lab. One of these genes is described below: PMP22 – Peripheral Myelin Protein 22 - An autosomal dominant trisomy of a 1.4Mb region on chromosome 17p12 containing the PMP22 gene results in Charcot-Marie-Tooth disease type-1A (CMT1A) which affects one out of 5000 people. CMT1A is the most common form of inherited neuropathy. A heterozygous deletion in the same region of chromosome 17p12 causes hereditary neuropathy with liability to pressure palsies (HNPP). Our studies utilize specimens from patients with CMT1A or HNPP, mouse models with Pmp22 gene manipulated, or culture Schwann cells/neurons to understand how the mutations damage myelin and axons. With respect to our clinical studies, Dr. Jun Li directs a CMT clinic that is specifically designated for the patients with inherited peripheral neuropathies. This multi-disciplinary clinic occurs weekly at Houston Methodist Hospital. We are interested in genotype/phenotype correlation, identification of novel genes causing CMT, and use of non-invasive quantitative MRI of peripheral nerve and human skin biopsy as biomarkers in the progression of peripheral nerve pathology. Our lab is a part of the NIH-funded Inherited Neuropathies Consortium.
For patients who are interested in visiting our clinic for clinical care, please call Rachel Davis at 713-441-9120 or email rgapplegate@houstonmethodist.org for an appointment.
Professor of Neurology, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
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