Greene Lab

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About the Lab

Our Team

Dr. Greene's research aims to characterize the peripheral immune inflammatory response in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, and identify the potential markers that may reflect disease activity and progression. Her translational research seeks to identify and develop effective therapies that positively alter the natural progression of these diseases. Dr. Greene’s research has demonstrated an apparent overreaction of the microglia cells that surround the motor neurons, thus providing a potential therapy in the form of homologous bone marrow-derived stem cell transplants.

Our Team

Ericka Greene, MD
The Sumner Family Distinguished Chair
in Neuromuscular Research, Stanley H. Appel Department of Neurology
Professor of Clinical Neurology, Academic Institute
Full Clinical Member, Research Institute

Clinical Research Team
Rachel Applegate, CCRC- 713.441.9120
Rosilyn Gborogen, RN, CCRP- 713.441.5192
Sharon Halton, CCRC- 713.441.3420
Patricia Mendoza, RN, CCRC- 713.441.5855

Research News
doctor holding a tablet with a chest scan on it's screen
Personalized Treatment Strategies for Lung Cancer
Houston Methodist researchers identified a novel and innovative marker to guide Immune Checkpoint Inhibitor Therapy for Lung Cancer.
woman sitting on an examination table in a doctor's office
Trailblazing New Perspectives: Treating Gynecological Cancers
The goal of this new study was to evaluate the feasibility of a phase three, multi-center randomized clinical trial comparing the efficacy of minimally invasive surgery with that of the traditional open method approach (laparotomy) in treating epithelial ovarian cancer.
arm in blood pressure testing machine
Getting to the Heart of Hypertension Disparities
Researchers address social risk factors for high blood pressure through a national study.
Evolving Treatment Beyond Pharmaceuticals
First-of-its-Kind Study Explores Novel Prescription Digital Therapeutic
An Unusual Presentation of Glioblastoma
Andrew Lee, MD, Herb and Jean Lyman Centennial Chair in Ophthalmology, recently published one of the first-ever reported cases of progressive vision loss as the presenting manifestation of recurrent GBM with secondary LMS to the optic chiasm.
Engaging T cell Exhaustion for Solid Tumor Immunotherapies
Houston Methodist researchers investigated T cell exhaustion in murine models of prostate cancer and melanoma to explore possible advancements in immunotherapies for solid tumors.
Fighting a Deadly Duo
Investigating therapeutics to fight deadly TB/HIV coinfections.
Houston Methodist, Rice University launch groundbreaking Digital Health Institute
This initiative builds on ongoing collaborations between Houston Methodist and Rice University to transform the future of health care.
Stage I Nodal Marginal Zone Lymphoma Treatment Landscape
Houston Methodist researchers compared systemic therapy and radiation therapy in Stage I Nodal Marginal Zone Lymphoma Patients
2024 Digital Health Workshop Seed Fund Award Winners Announced
Houston Methodist researchers and their collaborators from Rice University have been awarded grants from the 2024 PATHS-UP Digital Health Workshop.
Pilot Study Offers Insight Into Alzheimer’s Research Participants Perceptions and Self-Efficacy
In a Houston Methodist study, Alzheimer’s disease research participants showed a high interest in genetic testing and provided valuable insights that can improve how test results are disclosed.
Breast Cancer Cells
Nanomedicine Makes Big Strides in the Fight Against Breast Cancer
Researchers deliver immunotherapy directly into triple-negative breast cancer tumors with nanofluidic implants, achieving tunable and sustained dosing of immunotherapeutics with high anti-tumor activity.
headshot of Constance Mobley smiling
Liver Failure Avengers Houston Methodist Researchers First in World
Under the leadership of Constance Mobley, MD, PhD, FACS, researchers have successfully performed a first-in-human miniature liver hepatocyte transplant to change a patient’s lymph nodes into ectopic miniature livers.
Predicting the Future of Cancer Treatment

Houston Methodist faculty developed a multiscale mechanistic model to further investigate the role of miR-155 in non-small cell lung cancer and predict clinical efficacy based on preclinical data.

Taking a Closer Look at West Nile Neuroimaging

A case report reviewing West Nile neuroinvasive disease imaging characteristics and the differential diagnosis of acute leukoencephalopathy highlights the usefulness of neuroimaging in WNND diagnosis in the absence of CSF markers.

Ending Organ Transplant Rejection

Studies at Houston Methodist suggest a novel strategy that may potentially eliminate or diminish transplant rejection, autoimmune diseases, and the need for immunosuppressive drugs

Location, Location, Location is Key to Pancreatic Cancer Prognosis

Molecular alterations found in pancreatic ductal adenocarcinoma samples may have potential therapeutic implications

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